Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cholinergic receptor, muscarinic 2, cardiac
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Chrm2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Chrm2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autism, Susceptibility To, 20
Impaired social interactions OMIM:618830
Asperger Syndrome, X-Linked, Susceptibility To, 2
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:300497
Asperger Syndrome, X-Linked, Susceptibility To, 1
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:300494
Asperger Syndrome, Susceptibility To, 1
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Impaired ability to form peer relationships, Impaired use of nonverbal behaviors OMIM:608631
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
Chronic Atrial And Intestinal Dysrhythmia
Atrial flutter, Sick sinus syndrome, Atrial fibrillation, Decreased body weight, Pulmonic stenosi... OMIM:616201
Long Qt Syndrome 13
Paroxysmal atrial fibrillation, Atrial fibrillation, Hypertension, Pulmonary embolism, Atrioventr... OMIM:613485
Gallbladder Disease 1
Elevated hepatic transaminase, Cholesterol gallstones, Cholelithiasis, Hepatic fibrosis, Jaundice... OMIM:600803
Brugada Syndrome
Ventricular arrhythmia, Sick sinus syndrome, Ventricular fibrillation, Supraventricular tachycard... ORPHA:130
Budd-Chiari Syndrome
Peritonitis, Cirrhosis, Elevated hepatic transaminase, Gastrointestinal hemorrhage, Cholecystitis... ORPHA:131
Atrial Fibrillation, Familial, 18
Paroxysmal atrial fibrillation, Palpitations, Bradycardia, Permanent atrial fibrillation OMIM:617280
Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy
Paroxysmal supraventricular tachycardia, Atrial flutter, Ventricular extrasystoles, Atrial fibril... OMIM:616117
Atrial Standstill
Palpitations, Reduced ejection fraction, Arrhythmia, Dyspnea, Cardiac conduction abnormality, Atr... ORPHA:1344
Somatostatinoma
Extrahepatic cholestasis, Gastrointestinal hemorrhage, Intrahepatic cholestasis, Weight loss, Gal... ORPHA:97283
Metachromatic Leukodystrophy
Gallbladder dysfunction, Cholecystitis OMIM:250100
Peripartum Cardiomyopathy
Exertional dyspnea, Abnormal T-wave, Myocarditis, Pulmonary arterial hypertension, Obesity, Cardi... ORPHA:563
Hereditary Hemorrhagic Telangiectasia
Conjunctival telangiectasia, Cirrhosis, Gastrointestinal hemorrhage, Subarachnoid hemorrhage, Epi... ORPHA:774
Familial Short Qt Syndrome
Ventricular arrhythmia, Palpitations, Shortened QT interval, Atrial fibrillation, Sudden cardiac ... ORPHA:51083
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Cholelithiasis, Jaundice, Pigment gallstones, Splenomegaly, Cholecystitis OMIM:613470
Tako-Tsubo Cardiomyopathy
Ventricular arrhythmia, Prolonged QTc interval, Obesity, Cardiogenic shock, Syncope, Decreased QR... ORPHA:66529
Gallbladder Neuroendocrine Tumor
Biliary tract neoplasm, Extrahepatic cholestasis, Weight loss, Biliary tract obstruction, Intermi... ORPHA:100086
Hereditary Pulmonary Alveolar Proteinosis
Restrictive ventilatory defect, Respiratory distress, Cough, Respiratory failure requiring assist... ORPHA:264675
Intrahepatic Cholestasis Of Pregnancy
Elevated hepatic transaminase, Neonatal respiratory distress, Jaundice, Abnormality of the pancre... ORPHA:69665
Q Fever
Respiratory distress, Elevated hepatic transaminase, Pericarditis, Pleural effusion, Cough, Chole... ORPHA:781
Erythrocytosis, Familial, 8
Jaundice, Cholecystitis, Cholelithiasis, Splenomegaly OMIM:222800
Complete Atrioventricular Septal Defect
Wheezing, Elevated pulmonary artery pressure, Third heart sound, Crackles, Left-to-right shunt, A... ORPHA:1329
Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency
Jaundice, Cholecystitis, Cholelithiasis, Splenomegaly OMIM:235700
Pyruvate Kinase Deficiency Of Red Cells
Jaundice, Cholecystitis, Cholelithiasis, Splenomegaly OMIM:266200
Long Qt Syndrome 15
Ventricular fibrillation, Prolonged QT interval, Cardiac arrest, Bradycardia, Prolonged QTc interval OMIM:616249
Triosephosphate Isomerase Deficiency
Cholecystitis, Cholelithiasis, Respiratory insufficiency due to muscle weakness, Jaundice, Conges... OMIM:615512
Hsd10 Disease
Abnormal social behavior ORPHA:391417
Short Qt Syndrome 2
Shortened QT interval, Atrial fibrillation, Sudden cardiac death, Ventricular fibrillation, Brady... OMIM:609621
Glycogen Storage Disease Xii
Jaundice, Splenomegaly, Cholelithiasis, Cholecystitis OMIM:611881
Progressive Familial Heart Block, Type Ib
Arrhythmia, Atrioventricular block, Shortened PR interval, Prolonged QT interval, Left anterior f... OMIM:604559
Fucosidosis
Hepatomegaly, Abnormality of the gallbladder, Failure to thrive ORPHA:349
Peutz-Jeghers Syndrome
Biliary tract neoplasm, Abnormality of the gallbladder, Gastrointestinal hemorrhage, Pancreatic a... ORPHA:2869
Triploidy
Hepatomegaly, Abnormality of the pancreas, Abnormality of the gallbladder ORPHA:3376
11Q22.2Q22.3 Microdeletion Syndrome
Poor eye contact, Abnormal social behavior ORPHA:444002
Atrial Standstill 2
Palpitations, Dyspnea, Atrial standstill, Atrial cardiomyopathy, Atrial arrhythmia, Absent P wave... OMIM:615745
Rett Syndrome
Cholecystitis, Failure to thrive, Abnormal pattern of respiration ORPHA:778
Female Restricted Epilepsy With Intellectual Disability
Abnormal social behavior ORPHA:101039
Genitopalatocardiac Syndrome
Abnormality of mesentery morphology, Abnormality of the gallbladder ORPHA:2075
Listeriosis
Peritonitis, Arteritis, Respiratory distress, Pericarditis, Splenic abscess, Myocarditis, Pneumon... ORPHA:533
Dopa-Responsive Dystonia
Abnormal social behavior ORPHA:255
Vacterl/Vater Association
Abnormality of the pancreas, Abnormality of the gallbladder ORPHA:887
Neutral Lipid Storage Myopathy
Elevated hepatic transaminase, Chronic pancreatitis, Hepatic steatosis, Hepatomegaly, Congestive ... ORPHA:98908
Igg4-Related Kidney Disease
Abnormality of mesentery morphology, Arteritis, Pericarditis, Interstitial pneumonitis, Cholecyst... ORPHA:449395
Lamb-Shaffer Syndrome
Abnormal social behavior ORPHA:530983
Metachromatic Leukodystrophy, Adult Form
Neoplasm of the gallbladder, Orthostatic hypotension due to autonomic dysfunction, Cholecystitis ORPHA:309271
Kawasaki Disease
Arrhythmia, Pericarditis, Cholecystitis, Jaundice, Hepatitis, Congestive heart failure, Myocardit... ORPHA:2331
Congenitally Corrected Transposition Of The Great Arteries
Premature atrial contractions, Cardiac conduction abnormality, Supraventricular tachycardia with ... ORPHA:216694
Metachromatic Leukodystrophy, Late Infantile Form
Cholecystitis ORPHA:309256
Metachromatic Leukodystrophy, Juvenile Form
Cholecystitis ORPHA:309263
Wolf-Hirschhorn Syndrome
Abnormality of the gallbladder, Abdominal situs inversus, Failure to thrive ORPHA:280
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior ORPHA:1020
Childhood Absence Epilepsy
Abnormal social behavior ORPHA:64280
Smith-Lemli-Opitz Syndrome
Abnormality of the gallbladder ORPHA:818
48,Xxxy Syndrome
Abnormal social behavior ORPHA:96263
Fg Syndrome Type 1
Abnormal social behavior ORPHA:93932
Prader-Willi Syndrome Due To Translocation
Abnormal social behavior, Impaired social interactions ORPHA:177907
Dihydropyrimidine Dehydrogenase Deficiency
Abnormal social behavior ORPHA:1675
Koolen-De Vries Syndrome Due To A Point Mutation
Abnormal social behavior, Overfriendliness ORPHA:363965
17Q21.31 Microdeletion Syndrome
Abnormal social behavior, Overfriendliness ORPHA:363958
Mend Syndrome
Abnormal social behavior ORPHA:401973
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Abnormal social behavior ORPHA:314647
Tuberous Sclerosis Complex
Abnormal social behavior ORPHA:805
Niemann-Pick Disease Type C
Abnormal social behavior ORPHA:646
Williams Syndrome
Abnormal social behavior, Overfriendliness ORPHA:904

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chrm2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chrm2.

No publications found that use IMPC mice or data for Chrm2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter