Gene: Chd1

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Name
chromodomain helicase DNA binding protein 1
MGI ID
MGI:88393
Synonyms
4930525N21Rik
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
anophthalmia Chd1tm1b(KOMP)Wtsi HET Early adult 0.00
embryonic lethality prior to tooth bud stage Chd1tm1b(KOMP)Wtsi HOM E12.5 0.00
decreased bone mineral density Chd1tm1b(KOMP)Wtsi HET Early adult 1.78×10-05
decreased mean corpuscular hemoglobin concentration Chd1tm1b(KOMP)Wtsi HET Early adult 1.15×10-05
abnormal tooth morphology Chd1tm1b(KOMP)Wtsi HET Early adult 1.58×10-05
decreased hemoglobin content Chd1tm1b(KOMP)Wtsi HET Early adult 3.21×10-05
decreased red blood cell distribution width Chd1tm1b(KOMP)Wtsi HET Early adult 1.13×10-05
abnormal embryo size Chd1tm1b(KOMP)Wtsi HET E9.5 0.00
abnormal maxilla morphology Chd1tm1b(KOMP)Wtsi HET Early adult 1.58×10-05
embryonic lethality prior to organogenesis Chd1tm1b(KOMP)Wtsi HOM E9.5 0.00
embryonic growth retardation Chd1tm1b(KOMP)Wtsi HET E9.5 0.00
preweaning lethality, complete penetrance Chd1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal embryo size Chd1tm1b(KOMP)Wtsi HET E12.5 0.00
increased hematocrit Chd1tm1b(KOMP)Wtsi HET Early adult 5.84×10-06
abnormal eye morphology Chd1tm1b(KOMP)Wtsi HET E12.5 0.00
decreased lean body mass Chd1tm1b(KOMP)Wtsi HET Early adult 3.38×10-06

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 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/61)  (2/2) N/A
Brain 12  (6/504)  (2/12) N/A
Central nervous system ganglion 2  (1/70)  (2/2) N/A
Ear 12  (1/504)  (2/12) N/A
Embryo 12  (1/505)  (2/12) N/A
Eye 12  (1/504) N/A
Foot 12  (1/504) N/A
Forebrain 12  (1/504)  (2/12) N/A
Forelimb 12  (1/504)  (2/12) N/A
Gut 2  (1/56)  (2/2) N/A
Hand 12  (1/503) N/A
Head 12  (5/504)  (2/12) N/A
Heart 12  (1/504)  (2/12) N/A
Hindbrain 12  (6/504)  (2/12) N/A
Hindlimb 12  (1/503)  (2/12) N/A
Liver 12  (1/504)  (2/12) N/A
Lung 12  (1/500)  (2/12) N/A
Mandibular process 12  (1/504)  (2/12) N/A
Maxillary process 12  (1/504)  (2/12) N/A
Midbrain 12  (1/504)  (2/12) N/A
Nose 2  (1/70)  (2/2) N/A
Oral cavity 12  (1/504)  (2/12) N/A
Skeleton 2  (1/70)  (2/2) N/A
Skin 12  (1/504)  (2/12) N/A
Spinal cord 2  (1/69)  (2/2) N/A
Tail 12  (1/504)  (2/12) N/A
Tail somite 12  (1/504)  (2/12) N/A
Trachea 2  (1/56)  (2/2) N/A
Urinary system 2  (1/56)  (2/2) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
49 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Combined SHIRPA and Dysmorphology
4 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
Gross Pathology and Tissue Collection
8 Images
Eye Morphology: Images Slit Lamp
3 Images
X-ray: XRay Images Hind Leg and Hip
2 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Chd1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Chd1em1(IMPC)Wtsi Point Mutation Mice
Chd1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Chd1em2(IMPC)Wtsi Point Mutation Mice

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