Gene: Chd1

Name
chromodomain helicase DNA binding protein 1
MGI ID
MGI:88393
Synonyms
4930525N21Rik
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Chd1tm1b(KOMP)Wtsi HET embryonic day 9.5 0.00
preweaning lethality, complete penetrance Chd1tm1b(KOMP)Wtsi HOM n/a 0.00
decreased lean body mass Chd1tm1b(KOMP)Wtsi HET postnatal 3.38×10-06
decreased red blood cell distribution width Chd1tm1b(KOMP)Wtsi HET postnatal 1.43×10-05
embryonic lethality prior to organogenesis Chd1tm1b(KOMP)Wtsi HOM embryonic day 9.5 0.00
abnormal maxilla morphology Chd1tm1b(KOMP)Wtsi HET postnatal 1.58×10-05
embryonic lethality prior to tooth bud stage Chd1tm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
decreased bone mineral density Chd1tm1b(KOMP)Wtsi HET postnatal 1.78×10-05
abnormal tooth morphology Chd1tm1b(KOMP)Wtsi HET postnatal 1.58×10-05
decreased hemoglobin content Chd1tm1b(KOMP)Wtsi HET postnatal 2.30×10-05
anophthalmia Chd1tm1b(KOMP)Wtsi HET postnatal 0.00
decreased mean corpuscular hemoglobin concentration Chd1tm1b(KOMP)Wtsi HET postnatal 6.40×10-05
abnormal embryo size Chd1tm1b(KOMP)Wtsi HET embryonic day 12.5 0.00
increased hematocrit Chd1tm1b(KOMP)Wtsi HET postnatal 7.01×10-05
abnormal eye morphology Chd1tm1b(KOMP)Wtsi HET embryonic day 12.5 0.00
embryonic growth retardation Chd1tm1b(KOMP)Wtsi HET embryonic day 9.5 0.00

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 12  (6/485)  (2/12) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Ear 12  (1/485)  (2/12) N/A
Embryo 12  (1/485)  (2/12) N/A
Eye 12  (1/485) N/A
Foot 12  (1/485) N/A
Forebrain 12  (1/485)  (2/12) N/A
Forelimb 12  (1/485)  (2/12) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 12  (1/485) N/A
Head 12  (5/485)  (2/12) N/A
Heart 12  (1/485)  (2/12) N/A
Hindbrain 12  (6/485)  (2/12) N/A
Hindlimb 12  (1/485)  (2/12) N/A
Liver 12  (1/485)  (2/12) N/A
Lung 12  (1/485)  (2/12) N/A
Mandibular process 12  (1/485)  (2/12) N/A
Maxillary process 12  (1/485)  (2/12) N/A
Midbrain 12  (1/485)  (2/12) N/A
Nose 2  (1/51)  (2/2) N/A
Oral cavity 12  (1/485)  (2/12) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 12  (1/485)  (2/12) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 12  (1/485)  (2/12) N/A
Tail somite 12  (1/485)  (2/12) N/A
Trachea 2  (1/50)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Dorso Ventral
12 Images
Combined SHIRPA and Dysmorphology
4 Images
Eye Morphology: Images Slit Lamp
3 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Lateral Orientation
14 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
X-ray: XRay Images Hind Leg and Hip
2 Images
Histopathology
1 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Chd1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Chd1em2(IMPC)Wtsi Point Mutation Mice
Chd1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Chd1em1(IMPC)Wtsi Point Mutation Mice

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