F2 | coagulation factor II

GeneMGI:88380Synonyms: FII, Cf-2, +3 more

Physiological systems

17 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Mortality/aging

10 No significant impact

7 Not tested

Gene metrics:9Significant phenotypes
6Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased circulating fructosamine level1 supporting datasetF2tm1b(EUCOMM)HmguheterozygoteEarly adult8.52x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetF2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
decreased lean body mass2 supporting datasetsF2tm1b(EUCOMM)HmguheterozygoteEarly adult4.18x10-8 
decreased exploration in new environment1 supporting datasetF2tm1b(EUCOMM)HmguheterozygoteEarly adult1.48x10-8 
tremors1 supporting datasetF2tm1b(EUCOMM)HmguheterozygoteEarly adult2.7x10-6 
decreased bone mineral content2 supporting datasetsF2tm1b(EUCOMM)HmguheterozygoteEarly adult1.15x10-6 
increased circulating serum albumin level1 supporting datasetF2tm1b(EUCOMM)HmguheterozygoteEarly adult6.49x10-5 
decreased mean corpuscular volume1 supporting datasetF2tm1b(EUCOMM)HmguheterozygoteEarly adult8.99x10-5 
increased total body fat amount2 supporting datasetsF2tm1b(EUCOMM)HmguheterozygoteEarly adult1.84x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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F2tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
F2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
F2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
F2tm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell

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