Gene: Cdk4

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Phenotype System Allele Zyg Sex Life Stage P Value
female infertility Cdk4tm1b(NCOM)Mfgc HOM Early adult 0.00
abnormal cranium morphology Cdk4tm1b(NCOM)Mfgc HET Early adult 2.69×10-05
abnormal embryo size Cdk4tm1b(NCOM)Mfgc HOM E15.5 0.00
microphthalmia Cdk4tm1b(NCOM)Mfgc HOM E15.5 0.00
male infertility Cdk4tm1b(NCOM)Mfgc HOM Early adult 0.00
edema Cdk4tm1b(NCOM)Mfgc HOM E15.5 0.00
preweaning lethality, incomplete penetrance Cdk4tm1b(NCOM)Mfgc HOM Early adult 0.00

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/61)  (2/2) N/A
Brain 5  (6/504)  (2/11) N/A
Central nervous system ganglion 2  (1/70)  (2/2) N/A
Ear 5  (1/504)  (2/11) N/A
Embryo 5  (1/505)  (2/11) N/A
Eye 5  (1/504)  (2/11) N/A
Foot 5  (1/504)  (2/11) N/A
Forebrain 5  (1/504)  (2/11) N/A
Forelimb 5  (1/504)  (2/11) N/A
Gut 2  (1/56)  (2/2) N/A
Hand 5  (1/503)  (2/11) N/A
Head 5  (5/504)  (2/11) N/A
Heart 5  (1/504)  (2/11) N/A
Hindbrain 5  (6/504)  (2/11) N/A
Hindlimb 5  (1/503)  (2/11) N/A
Liver 5  (1/504)  (2/11) N/A
Lung 5  (1/500)  (2/11) N/A
Mandibular process 5  (1/504)  (2/11) N/A
Maxillary process 5  (1/504)  (2/11) N/A
Midbrain 5  (1/504)  (2/11) N/A
Nose 2  (1/70)  (2/2) N/A
Oral cavity 5  (1/504)  (2/11) N/A
Skeleton 2  (1/70)  (2/2) N/A
Skin 5  (1/504)  (2/11) N/A
Spinal cord 2  (1/69)  (2/2) N/A
Tail 5  (1/504)  (2/11) N/A
Tail somite 5  (1/504)  (2/11) N/A
Trachea 2  (1/56)  (2/2) N/A
Urinary system 2  (1/56)  (2/2) N/A

 Associated Images

Gross Morphology Embryo E14.5-E15.5
6 Images
Embryo LacZ: LacZ images wholemount
44 Images
Histopathology
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
X-ray: XRay Images Whole Body Lateral Orientation
12 Images
X-ray: XRay Images Skull Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
Gross Pathology and Tissue Collection
12 Images
Eye Morphology: Images Ophthalmoscopy
4 Images
Eye Morphology: Images Slit Lamp
3 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Epididymis - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM Early adult
Testes - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM Early adult
Pancreas - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM Early adult
Ovary - developmental and structural abnormality Cdk4tm1b(NCOM)Mfgc HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cdk4tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cdk4tm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Cdk4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cdk4tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdk4tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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