Gene: Cdk4

Name
cyclin-dependent kinase 4
MGI ID
MGI:88357
Synonyms
Crk3 p34/cdk4
Viability
Homozygous - Subviable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
male infertility Cdk4tm1b(NCOM)Mfgc HOM postpartum stage 0.00
microphthalmia Cdk4tm1b(NCOM)Mfgc HOM embryonic day 15.5 0.00
female infertility Cdk4tm1b(NCOM)Mfgc HOM postpartum stage 0.00
preweaning lethality, incomplete penetrance Cdk4tm1b(NCOM)Mfgc HOM n/a 0.00
edema Cdk4tm1b(NCOM)Mfgc HOM embryonic day 15.5 0.00
abnormal embryo size Cdk4tm1b(NCOM)Mfgc HOM embryonic day 15.5 0.00

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Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 5  (6/485)  (2/11) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Ear 5  (1/485)  (2/11) N/A
Embryo 5  (1/485)  (2/11) N/A
Eye 5  (1/485)  (2/11) N/A
Foot 5  (1/485)  (2/11) N/A
Forebrain 5  (1/485)  (2/11) N/A
Forelimb 5  (1/485)  (2/11) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 5  (1/485)  (2/11) N/A
Head 5  (5/485)  (2/11) N/A
Heart 5  (1/485)  (2/11) N/A
Hindbrain 5  (6/485)  (2/11) N/A
Hindlimb 5  (1/485)  (2/11) N/A
Liver 5  (1/485)  (2/11) N/A
Lung 5  (1/485)  (2/11) N/A
Mandibular process 5  (1/485)  (2/11) N/A
Maxillary process 5  (1/485)  (2/11) N/A
Midbrain 5  (1/485)  (2/11) N/A
Nose 2  (1/51)  (2/2) N/A
Oral cavity 5  (1/485)  (2/11) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 5  (1/485)  (2/11) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 5  (1/485)  (2/11) N/A
Tail somite 5  (1/485)  (2/11) N/A
Trachea 2  (1/50)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
36 Images
Eye Morphology: Images Slit Lamp
3 Images
Gross Pathology and Tissue Collection
12 Images
X-ray: XRay Images Dorso Ventral
12 Images
X-ray: XRay Images Skull Lateral Orientation
12 Images
Histopathology
12 Images
X-ray: XRay Images Lateral Orientation
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Gross Morphology Embryo E14.5-E15.5
6 Images
Eye Morphology: Images Ophthalmoscopy
4 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Pancreas - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM postnatal
Ovary - developmental and structural abnormality Cdk4tm1b(NCOM)Mfgc HOM postnatal
Epididymis - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM postnatal
Testes - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cdk4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cdk4tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdk4tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdk4tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cdk4tm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice

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