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Genes Phenotypes

Gene: Cdk4

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Name
cyclin-dependent kinase 4
MGI ID
MGI:88357
Synonyms
p34PSK-J3/cdk4 Crk3
Viability
Subviable
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (7) Measurements chart (207) All data table (1205)
Expression & images (29) Disease models (0) Histopathology (4) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Cdk4tm1b(NCOM)Mfgc HOM   Early adult 0.00
decreased body length Cdk4tm1b(NCOM)Mfgc HET Early adult 3.32×10-06
abnormal embryo size Cdk4tm1b(NCOM)Mfgc HOM E15.5 0.00
abnormal cranium morphology Cdk4tm1b(NCOM)Mfgc HET   Early adult 2.69×10-05
male infertility Cdk4tm1b(NCOM)Mfgc HOM Early adult 0.00
abnormal embryo size Cdk4tm1b(NCOM)Mfgc HET E15.5 0.00
female infertility Cdk4tm1b(NCOM)Mfgc HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 5  (6/506)  (2/11) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Ear 5  (1/506)  (2/11) N/A
Embryo 5  (1/507)  (2/11) N/A
Eye 5  (1/506)  (2/11) N/A
Foot 5  (1/506)  (2/11) N/A
Forebrain 5  (1/506)  (2/11) N/A
Forelimb 5  (1/506)  (2/11) N/A
Gut 2  (1/60)  (2/2) N/A
Hand 5  (1/506)  (2/11) N/A
Head 5  (5/506)  (2/11) N/A
Heart 5  (1/506)  (2/11) N/A
Hindbrain 5  (6/506)  (2/11) N/A
Hindlimb 5  (1/506)  (2/11) N/A
Liver 5  (1/504)  (2/11) N/A
Lung 5  (1/504)  (2/11) N/A
Mandibular process 5  (1/506)  (2/11) N/A
Maxillary process 5  (1/506)  (2/11) N/A
Midbrain 5  (1/506)  (2/11) N/A
Nose 2  (1/76)  (2/2) N/A
Oral cavity 5  (1/504)  (2/11) N/A
Skeleton 2  (1/76)  (2/2) N/A
Skin 5  (1/506)  (2/11) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Tail 5  (1/506)  (2/11) N/A
Tail somite 5  (1/506)  (2/11) N/A
Trachea 2  (1/60)  (2/2) N/A
Urinary system 2  (1/60)  (2/2) N/A

 Associated Images

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X-ray: XRay Images Skull Lateral Orientation
12 Images
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Histopathology
12 Images
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X-ray: XRay Images Whole Body Dorso Ventral
12 Images
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Embryo LacZ: LacZ images wholemount
44 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
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Gross Pathology and Tissue Collection
12 Images
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Gross Morphology Embryo E14.5-E15.5
6 Images
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X-ray: XRay Images Whole Body Lateral Orientation
12 Images
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Eye Morphology: Images Ophthalmoscopy
4 Images
Immunophenotyping: Panel A FCS file(s)
1 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Epididymis - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM Early adult
Testes - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM Early adult
Ovary - developmental and structural abnormality Cdk4tm1b(NCOM)Mfgc HOM Early adult
Pancreas - hypoplasia Cdk4tm1b(NCOM)Mfgc HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cdk4tm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Cdk4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cdk4tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdk4tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cdk4tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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