The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cd7 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd7.
There are 2 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.||Circulation research (March 2016)||Cd70tm1(KOMP)Vlcg||PMC4833561|
|T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs.||European journal of immunology (August 2015)||Cd70tm1(KOMP)Vlcg||PMC4674305|
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|MGI Allele||Allele Type||Produced|
|Cd7tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|
|Cd7tm1b(KOMP)Wtsi||Reporter-tagged deletion allele (with selection cassette)||Mice|
|Cd7tm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|