Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
CD34 antigen
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cd34 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd34 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Porokeratosis
Squamous cell carcinoma of the skin, Hyperkeratosis ORPHA:79358
Huriez Syndrome
Nail dystrophy, Congenital palmoplantar hyperkeratosis, Squamous cell carcinoma of the skin OMIM:181600
Epidermodysplasia Verruciformis, Susceptibility To, 5
Verrucae, Lymphopenia, Squamous cell carcinoma of the skin, T lymphocytopenia OMIM:618309
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Thrombocytosis, Neutropenia, Monocytosis, Congenital agranulocytosis, Anemia, Acute monocytic leu... OMIM:202700
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Palmoplantar keratoderma, Squamous cell carcinoma of the skin ORPHA:85112
Cutaneous Neuroendocrine Carcinoma
Multiple myeloma, Lymphoid leukemia, Brain neoplasm, Basal cell carcinoma, Squamous cell carcinom... ORPHA:79140
Apc-Related Attenuated Familial Adenomatous Polyposis
Astrocytoma, Adenomatous colonic polyposis, Multiple gastric polyps, Papillary thyroid carcinoma,... ORPHA:247806
Familial Multinodular Goiter
Colorectal polyposis, Ovarian neoplasm, Testicular seminoma, Thyroid carcinoma, Sertoli cell neop... ORPHA:276399
Gardner Syndrome
Astrocytoma, Adenomatous colonic polyposis, Small intestine carcinoid, Brain neoplasm, Papillary ... ORPHA:79665
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin, Albinism, Hyperkeratosis, Hypopigmenta... ORPHA:79431
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Chronic Myeloid Leukemia
Leukocytosis, Abnormal basophil morphology, Thrombocytosis, Abnormal granulocyte morphology, Sple... ORPHA:521
Epidermodysplasia Verruciformis, X-Linked
Verrucae, Squamous cell carcinoma of the skin OMIM:305350
Dyskeratosis Congenita, Autosomal Dominant 1
Myelodysplasia, Sparse hair, Nail dystrophy, Alopecia, Anemia, Squamous cell carcinoma of the ski... OMIM:127550
Turcot Syndrome With Polyposis
Astrocytoma, Thyroid carcinoma, Adenomatous colonic polyposis, Leukemia, Brain neoplasm, Basal ce... ORPHA:99818
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Albinism, Hypopigmentation of hair, Me... ORPHA:79434
Oculocutaneous Albinism
Cutaneous melanoma, White hair, Basal cell carcinoma, Squamous cell carcinoma of the skin, Genera... ORPHA:55
Hermansky-Pudlak Syndrome
Neutropenia, Basal cell carcinoma, Long eyelashes, Squamous cell carcinoma of the skin, Hyperkera... ORPHA:79430
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
Oculocutaneous Albinism Type 2
Cutaneous melanoma, White hair, Basal cell carcinoma, Squamous cell carcinoma of the skin, White ... ORPHA:79432
Pilomatrixoma
Pilomatrixoma OMIM:132600
Xeroderma Pigmentosum, Complementation Group C
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin OMIM:278720
Lmna-Related Cardiocutaneous Progeria Syndrome
Basal cell carcinoma, Absent eyebrow, Squamous cell carcinoma of the skin, Absent eyelashes, Pulm... ORPHA:363618
Xeroderma Pigmentosum, Complementation Group B
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin, Neoplasm OMIM:610651
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Nail dystrophy, Palmoplantar keratoderma, Anemia, Squamous cell carcinoma of the skin, Alopecia ORPHA:79396
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:220295
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Spinal cord tumor, Pilomatrixoma, Meningioma, Neoplasm ORPHA:353281
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Trichiasis, Pilomatrixoma, Meningioma, Highly arched eyebrow ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Trichiasis, Pilomatrixoma, Meningioma, Highly arched eyebrow ORPHA:353277
Tetrasomy 9P
Pilomatrixoma ORPHA:3310

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd34

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd34.

No publications found that use IMPC mice or data for Cd34.

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MGI Allele Allele Type Produced
Cd34tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd34tm94189(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Cd34tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd34tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Cd34tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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