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Gene: Cck MGI:88297

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Gene Summary

Name:
cholecystokinin
Synonyms:
N/A

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal kidney morphology Ccktm2b(EUCOMM)Hmgu HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote Ambiguous
Adrenal gland N/A homozygote Ambiguous
Aorta N/A heterozygote 0.0% (0 of 4)
Aorta N/A homozygote 0.0% (0 of 2)
Bone N/A heterozygote Ambiguous
Bone N/A homozygote Ambiguous
Brain N/A heterozygote 100% (4 of 4)
Brain N/A homozygote 100% (2 of 2)
Brainstem N/A heterozygote 100% (4 of 4)
Brainstem N/A homozygote 100% (2 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 4)
Brown adipose tissue N/A homozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote Ambiguous
Cartilage tissue N/A homozygote Ambiguous
Cecum N/A heterozygote Ambiguous
Cecum N/A homozygote Ambiguous
Cerebellum N/A heterozygote 100% (4 of 4)
Cerebellum N/A homozygote 100% (2 of 2)
Cerebral cortex N/A heterozygote 100% (4 of 4)
Cerebral cortex N/A homozygote 100% (2 of 2)
Chest bone N/A heterozygote Ambiguous
Chest bone N/A homozygote Ambiguous
Colon N/A heterozygote Ambiguous
Colon N/A homozygote Ambiguous
Cranium N/A heterozygote Ambiguous
Cranium N/A homozygote Ambiguous
Diaphragm N/A heterozygote 0.0% (0 of 4)
Diaphragm N/A homozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 100% (4 of 4)
Duodenum N/A homozygote 100% (2 of 2)
Epididymis N/A heterozygote Not available
Epididymis N/A homozygote Not available
Esophagus N/A heterozygote 0.0% (0 of 4)
Esophagus N/A homozygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 4)
Eye N/A homozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Ambiguous
Gall bladder N/A homozygote Ambiguous
Gonadal fat pad N/A heterozygote 0.0% (0 of 4)
Gonadal fat pad N/A homozygote 0.0% (0 of 2)
Harderian gland N/A heterozygote Ambiguous
Harderian gland N/A homozygote Ambiguous
Heart N/A heterozygote 0.0% (0 of 4)
Heart N/A homozygote 0.0% (0 of 2)
Hindlimb N/A heterozygote 0.0% (0 of 4)
Hindlimb N/A homozygote 0.0% (0 of 2)
Hippocampus N/A heterozygote 100% (4 of 4)
Hippocampus N/A homozygote 100% (2 of 2)
Hypothalamus N/A heterozygote 100% (4 of 4)
Hypothalamus N/A homozygote 100% (2 of 2)
Ileum N/A heterozygote 100% (4 of 4)
Ileum N/A homozygote 100% (2 of 2)
Jejunum N/A heterozygote 100% (4 of 4)
Jejunum N/A homozygote 100% (2 of 2)
Kidney N/A heterozygote 100% (4 of 4)
Kidney N/A homozygote 100% (2 of 2)
Large intestine N/A heterozygote Ambiguous
Large intestine N/A homozygote Ambiguous
Liver N/A heterozygote Ambiguous
Liver N/A homozygote Ambiguous
Lower urinary tract N/A heterozygote Ambiguous
Lower urinary tract N/A homozygote Ambiguous
Lung N/A heterozygote Ambiguous
Lung N/A homozygote Ambiguous
Lymph node N/A heterozygote Ambiguous
Lymph node N/A homozygote Ambiguous
Main olfactory bulb N/A heterozygote 100% (4 of 4)
Main olfactory bulb N/A homozygote 100% (2 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 4)
Mammary gland N/A homozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 4)
Mesenteric adipose tissue N/A homozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote Ambiguous
Mesenteric lymph node N/A homozygote Ambiguous
Midbrain N/A heterozygote 100% (4 of 4)
Midbrain N/A homozygote 100% (2 of 2)
Olfactory lobe N/A heterozygote 100% (4 of 4)
Olfactory lobe N/A homozygote 100% (2 of 2)
Oral epithelium N/A heterozygote 0.0% (0 of 4)
Oral epithelium N/A homozygote 0.0% (0 of 2)
Ovary N/A heterozygote Not available
Ovary N/A homozygote Not available
Oviduct N/A heterozygote Not available
Oviduct N/A homozygote Not available
Pancreas N/A heterozygote 0.0% (0 of 4)
Pancreas N/A homozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 4)
Parathyroid gland N/A homozygote 0.0% (0 of 2)
Parotid gland N/A heterozygote Ambiguous
Parotid gland N/A homozygote Ambiguous
Penis N/A heterozygote 0.0% (0 of 4)
Penis N/A homozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote 0.0% (0 of 4)
Peripheral nervous system N/A homozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 4)
Peyer's patch N/A homozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote Not available
Pituitary gland N/A homozygote Ambiguous
Prostate gland N/A heterozygote Not available
Prostate gland N/A homozygote Not available
Quadriceps N/A heterozygote 0.0% (0 of 4)
Quadriceps N/A homozygote 0.0% (0 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 4)
Sciatic nerve N/A homozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote 0.0% (0 of 4)
Skeletal muscle N/A homozygote 0.0% (0 of 2)
Skin N/A heterozygote Ambiguous
Skin N/A homozygote Ambiguous
Small intestine N/A heterozygote 100% (4 of 4)
Small intestine N/A homozygote 100% (2 of 2)
Spinal cord N/A heterozygote 100% (4 of 4)
Spinal cord N/A homozygote 100% (2 of 2)
Spleen N/A heterozygote Ambiguous
Spleen N/A homozygote Ambiguous
Stomach pyloric region N/A heterozygote 0.0% (0 of 4)
Stomach pyloric region N/A homozygote 0.0% (0 of 2)
Stomach N/A heterozygote Ambiguous
Stomach N/A homozygote Ambiguous
Striatum N/A heterozygote 0.0% (0 of 4)
Striatum N/A homozygote Ambiguous
Sublingual gland N/A heterozygote Ambiguous
Sublingual gland N/A homozygote Ambiguous
Submandibular gland N/A heterozygote Ambiguous
Submandibular gland N/A homozygote Ambiguous
Testis N/A heterozygote 50% (2 of 4)
Testis N/A homozygote 50% (1 of 2)
Thalamus N/A heterozygote 100% (4 of 4)
Thalamus N/A homozygote 100% (2 of 2)
Thymus N/A heterozygote Ambiguous
Thymus N/A homozygote Ambiguous
Thyroid gland N/A heterozygote Ambiguous
Thyroid gland N/A homozygote Ambiguous
Tongue N/A heterozygote 0.0% (0 of 4)
Tongue N/A homozygote 0.0% (0 of 2)
Trachea N/A heterozygote Ambiguous
Trachea N/A homozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 4)
Trigeminal V nerve N/A homozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote Ambiguous
Urinary bladder N/A homozygote Ambiguous
Uterus N/A heterozygote Not available
Uterus N/A homozygote Not available
Vagina N/A heterozygote 0.0% (0 of 4)
Vagina N/A homozygote 0.0% (0 of 2)
Vas deferens N/A heterozygote Not available
Vas deferens N/A homozygote Not available
Vascular system N/A heterozygote 0.0% (0 of 4)
Vascular system N/A homozygote 0.0% (0 of 2)
Vesicular gland N/A heterozygote Not available
Vesicular gland N/A homozygote Not available
White adipose tissue N/A heterozygote 0.0% (0 of 4)
White adipose tissue N/A homozygote 0.0% (0 of 2)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Brain N/A heterozygote 100% (9 of 9)
Ear N/A heterozygote 0.0% (0 of 9)
Embryo N/A heterozygote 100% (9 of 9)
Eye N/A heterozygote 0.0% (0 of 9)
Footplate N/A heterozygote 100% (9 of 9)
Forearm N/A heterozygote 0.0% (0 of 9)
Forebrain N/A heterozygote 100% (9 of 9)
Forelimb N/A heterozygote 0.0% (0 of 9)
Handplate N/A heterozygote 0.0% (0 of 9)
Head N/A heterozygote 100% (9 of 9)
Heart N/A heterozygote 100% (9 of 9)
Hindbrain N/A heterozygote 0.0% (0 of 9)
Hindlimb N/A heterozygote 100% (9 of 9)
Liver N/A heterozygote 0.0% (0 of 9)
Lower leg N/A heterozygote 0.0% (0 of 9)
Lung N/A heterozygote 0.0% (0 of 9)
Mandibular process N/A heterozygote 0.0% (0 of 9)
Maxillary process N/A heterozygote 0.0% (0 of 9)
Midbrain N/A heterozygote 0.0% (0 of 9)
Oral cavity N/A heterozygote 0.0% (0 of 9)
Skin N/A heterozygote 0.0% (0 of 9)
Tail somite N/A heterozygote 0.0% (0 of 9)
Tail N/A heterozygote 0.0% (0 of 9)
Upper arm N/A heterozygote 0.0% (0 of 9)
Upper leg N/A heterozygote 0.0% (0 of 9)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
chest bone
colon
cranium
diaphragm 0.0%
duodenum 0.0%
epididymis Unavailable
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland
heart 0.0%
hindlimb 0.0%
hippocampus 0.0%
hypothalamus 0.0%
ileum 0.0%
jejunum
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
main olfactory bulb 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node
midbrain 0.0%
olfactory lobe 0.0%
oral epithelium 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
stomach pyloric region 0.0%
striatum 0.0%
sublingual gland 0.0%
submandibular gland 0.0%
testis 0.0%
thalamus 0.0%
thymus 0.0%
thyroid gland 0.0%
tongue 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vagina 0.0%
vas deferens Unavailable
vascular system 0.0%
vesicular gland Unavailable
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 0.0%
ear 0.0%
embryo 0.0%
eye 0.0%
footplate 0.0%
forearm Ambiguous
forebrain 0.0%
forelimb 0.0%
handplate 0.0%
head 0.0%
heart 0.0%
hindbrain 0.0%
hindlimb 0.0%
liver 0.0%
lower leg Ambiguous
lung 0.0%
mandibular process 0.0%
maxillary process 0.0%
midbrain 0.0%
oral cavity 0.0%
skin 0.0%
tail 0.0%
tail somite group 0.0%
upper arm Ambiguous
upper leg Ambiguous

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Wholemount

333 Images

View images
Embryo LacZ

LacZ images wholemount

24 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

10 Images

View images
Gross Pathology and Tissue Collection

Images

2 Images

View images
X-ray

XRay Images Whole Body Lateral Orientation

10 Images

View images
Eye Morphology

Images Slit Lamp

1 Images

View images
Eye Morphology

Images Ophthalmoscopy

6 Images

View images

Human diseases caused by Cck mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cck by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Multiple Endocrine Neoplasia Type 4
Hyperparathyroidism, Increased circulating cortisol level, Insulinoma, Abnormality of pancreas ph... ORPHA:276152

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cck

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cck.

No publications found that use IMPC mice or data for Cck.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ccktm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ccktm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ccktm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Ccktm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ccktm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ccktm2b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Ccktm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ccktm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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