Genes Phenotypes

Gene: Cacna1b

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Name
calcium channel, voltage-dependent, N type, alpha 1B subunit
MGI ID
MGI:88296
Synonyms
alpha(1B) Cchn1a Cav2.2
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (5) Measurements chart (155) All data table (345)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal gait Cacna1btm1b(KOMP)Wtsi HOM Early adult 6.26×10-10
decreased grip strength Cacna1btm1b(KOMP)Wtsi HOM Early adult 7.73×10-10
hyperactivity Cacna1btm1b(KOMP)Wtsi HOM Early adult 8.03×10-13
abnormal behavior Cacna1btm1b(KOMP)Wtsi HOM Early adult 6.71×10-09
abnormal locomotor behavior Cacna1btm1b(KOMP)Wtsi HOM Early adult 9.11×10-06

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (1)
Adrenal gland expression
MA:0000116
nervous system (5)
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Brainstem expression
Brain expression
MA:0000185
MA:0000891
MA:0000191
MA:0000173
MA:0000169
MA:0000168
postnatal mouse (11)
Adrenal gland expression
MA:0000116
reproductive system (1)
Testis expression
MA:0000411
trunk (6)
Adrenal gland expression
MA:0000116
urinary system (1)
Lower Urinary Tract expression
MA:0002636
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (4/4) N/A
Ear 2  (1/504)  (1/4) N/A
Embryo 2  (1/505)  (4/4) N/A
Eye 2  (1/504)  (2/4) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504)  (2/4) N/A
Forelimb 2  (1/504) N/A
Hand 2  (1/503) N/A
Head 2  (5/504)  (4/4) N/A
Heart 2  (1/504) Image Only N/A
Hindbrain 2  (6/504)  (4/4) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504)  (3/4) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A

 Associated Images

Echo: M-Mode Images
32 Images
Adult LacZ: LacZ Images Wholemount
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
Embryo LacZ: LacZ images wholemount
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cacna1btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cacna1btm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Cacna1btm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice

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