Genes Phenotypes

Gene: Cacna1b

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Name
calcium channel, voltage-dependent, N type, alpha 1B subunit
MGI ID
MGI:88296
Synonyms
alpha(1B) Cchn1a Cav2.2
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (8) Measurements chart (242) All data table (529)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
hyperactivity Cacna1btm1b(KOMP)Wtsi HOM postnatal 3.69×10-12
abnormal locomotor behavior Cacna1btm1b(KOMP)Wtsi HOM postnatal 1.78×10-05
abnormal gait Cacna1btm1b(KOMP)Wtsi HOM postnatal 7.07×10-10
increased circulating triglyceride level Cacna1btm1b(KOMP)Wtsi HOM postnatal 2.25×10-10
decreased grip strength Cacna1btm1b(KOMP)Wtsi HOM postnatal 1.99×10-09
decreased neutrophil cell number Cacna1btm1b(KOMP)Wtsi HOM postnatal 8.73×10-05
abnormal behavior Cacna1btm1b(KOMP)Wtsi HOM postnatal 7.88×10-09
increased circulating alanine transaminase level Cacna1btm1b(KOMP)Wtsi HOM postnatal 2.63×10-05

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (1)
Adrenal gland expression
MA:0000116
nervous system (5)
Cerebral Cortex expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Brainstem expression
Brain expression
MA:0000185
MA:0000891
MA:0000191
MA:0000173
MA:0000169
MA:0000168
postnatal mouse (11)
Adrenal gland expression
MA:0000116
reproductive system (1)
Testis expression
MA:0000411
trunk (6)
Adrenal gland expression
MA:0000116
urinary system (1)
Lower Urinary Tract expression
MA:0002636
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (4/4) N/A
Ear 2  (1/485)  (1/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (2/4) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485)  (2/4) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (4/4) N/A
Heart 2  (1/485) Image Only N/A
Hindbrain 2  (6/485)  (4/4) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485)  (3/4) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Echo: M-Mode Images
32 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
Adult LacZ: LacZ Images Wholemount
11 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Lateral Orientation
11 Images
X-ray: XRay Images Dorso Ventral
11 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cacna1btm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Cacna1btm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Cacna1btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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