Gene: Cacna1b

Name
calcium channel, voltage-dependent, N type, alpha 1B subunit
MGI ID
MGI:88296
Synonyms
alpha(1B) Cchn1a Cav2.2
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Cacna1btm1b(KOMP)Wtsi HOM postnatal 1.99×10-09
decreased neutrophil cell number Cacna1btm1b(KOMP)Wtsi HOM postnatal 8.73×10-05
increased circulating alanine transaminase level Cacna1btm1b(KOMP)Wtsi HOM postnatal 2.63×10-05
abnormal gait Cacna1btm1b(KOMP)Wtsi HOM postnatal 7.07×10-10
hyperactivity Cacna1btm1b(KOMP)Wtsi HOM postnatal 3.69×10-12
increased circulating triglyceride level Cacna1btm1b(KOMP)Wtsi HOM postnatal 2.25×10-10
abnormal behavior Cacna1btm1b(KOMP)Wtsi HOM postnatal 7.88×10-09

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (4/4) N/A
Ear 2  (1/485)  (1/4) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (2/4) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485)  (2/4) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (4/4) N/A
Heart 2  (1/485) Image Only N/A
Hindbrain 2  (6/485)  (4/4) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485)  (3/4) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Echo: M-Mode Images
32 Images
X-ray: XRay Images Lateral Orientation
11 Images
Adult LacZ: LacZ Images Wholemount
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Dorso Ventral
11 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cacna1btm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Cacna1btm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Cacna1btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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