Gene: Cacna1s

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Name
calcium channel, voltage-dependent, L type, alpha 1S subunit
MGI ID
MGI:88294
Synonyms
fmd sj Cchl1a3 mdg Cav1.1 muscle dysgenesis DHPR alpha1s
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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
respiratory system phenotype Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 18.5 0.00
edema Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
cyanosis Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 18.5 0.00
abnormal embryo size Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 18.5 0.00
abnormal facial morphology Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 18.5 0.00
abnormal placenta vasculature Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
preweaning lethality, complete penetrance Cacna1stm1.1(KOMP)Vlcg HOM n/a 0.00
hemorrhage Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
decreased circulating glucose level Cacna1stm1.1(KOMP)Vlcg HET postnatal 4.64×10-05
hemorrhage Cacna1stm1.1(KOMP)Vlcg HOM embryonic day 18.5 0.00
increased bone mineral content Cacna1stm1.1(KOMP)Vlcg HET postnatal 7.53×10-05

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2) N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No  (2/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Urinary bladder 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Dorsal root ganglion 1  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (1/3)  Wholemount images
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485)  (1/3) N/A
Fronto-nasal process 1  (1/48) N/A
Hand 2  (1/485)  (1/3) N/A
Head 2  (5/485)  (1/3) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Nose 1  (1/51) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485)  (1/3) N/A
Spinal cord 1  (1/50) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
X-ray: XRay Images Forepaw
11 Images
Sleep Wake: Wake state (bmp file)
12 Images
X-ray: XRay Images Dorso Ventral
11 Images
X-ray: XRay Images Lateral Orientation
11 Images
Embryo LacZ: LacZ images wholemount
8 Images
Electroretinography: Rod waveform (pdf format)
4 Images
Electroretinography: Cone waveform (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cacna1stm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Cacna1stm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Cacna1stm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells