Gene: Cacna1s

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Name
calcium channel, voltage-dependent, L type, alpha 1S subunit
MGI ID
MGI:88294
Synonyms
Cchl1a3 fmd mdg sj muscle dysgenesis Cav1.1 DHPR alpha1s
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
unresponsive to tactile stimuli Cacna1stm1.1(KOMP)Vlcg HOM E18.5 0.00
abnormal facial morphology Cacna1stm1.1(KOMP)Vlcg HOM E18.5 0.00
abnormal placenta vasculature Cacna1stm1.1(KOMP)Vlcg HOM E15.5 0.00
edema Cacna1stm1.1(KOMP)Vlcg HOM E15.5 0.00
cyanosis Cacna1stm1.1(KOMP)Vlcg HOM E18.5 0.00
respiratory system phenotype Cacna1stm1.1(KOMP)Vlcg HOM E18.5 0.00
decreased circulating glucose level Cacna1stm1.1(KOMP)Vlcg HET   Early adult 4.77×10-05
preweaning lethality, complete penetrance Cacna1stm1.1(KOMP)Vlcg HOM   Early adult 0.00
abnormal embryo size Cacna1stm1.1(KOMP)Vlcg HOM E18.5 0.00
hemorrhage Cacna1stm1.1(KOMP)Vlcg HOM E18.5 0.00
hemorrhage Cacna1stm1.1(KOMP)Vlcg HOM E15.5 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 1 No  (4/583) N/A
Aorta 1 No  (1/583) N/A
Brain 1 No  (4/583)  (1/1)  Section images
Brainstem 1 No  (2/583)  (1/1)  Section images
Brown adipose tissue 1 No N/A
Cartilage tissue 1 No  (1/583) N/A
Cerebellum 1 No  (3/583)  (1/1)  Section images
Cerebral cortex 1 No  (2/583) N/A
Epididymis 1 No  (18/132) N/A
Esophagus 1 No  (7/407) N/A
Eye 1 No  (1/1)  Section images
Heart 1 No  (2/583) N/A
Hippocampus 1 No  (3/583) N/A
Hypothalamus 1 No  (2/583) N/A
Kidney 1 No  (21/583)  (1/1)  Section images
Large intestine 1 No  (10/583) N/A
Liver 1 No N/A
Lower urinary tract 1 No  (1/583) N/A
Lung 1 No  (2/583) N/A
Lymph node 1 No  (1/583) N/A
Mammary gland 1 No N/A
Midbrain 1 No  (1/1)  Section images
Olfactory lobe 1 No  (2/583) N/A
Ovary 1 No  (1/583) N/A
Oviduct 1 No N/A
Pancreas 1 No  (5/583) N/A
Peripheral nervous system 1 No  (2/583) N/A
Peyer's patch 1 No N/A
Pituitary gland 1 No  (1/583) N/A
Prostate gland 1 No  (12/583) N/A
Skeletal muscle 1 No N/A
Skin 1 No  (1/583) N/A
Small intestine 1 No  (9/583)  (1/1)  Section images
Spinal cord 1 No  (3/583) N/A
Spleen 1 No  (3/583) N/A
Stomach 1 No  (13/583) N/A
Striatum 1 No  (3/583) N/A
Submandibular gland 1 No  (2/130)  (1/1)  Section images
Testis 1 No  (6/583)  (1/1)  Section images
Thalamus 1 No  (1/1)  Section images
Thymus 1 No  (1/583) N/A
Thyroid gland 1 No  (17/583)  (1/1)  Section images
Trachea 1 No  (3/583)  (1/1)  Section images
Urinary bladder 1 No N/A
Uterus 1 No N/A
Vascular system 1 No N/A
Vesicular gland 1 No N/A
White adipose tissue 1 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505) N/A
1  (1/60) N/A
2  (1/505) N/A
2  (1/506)  (1/3)  Wholemount images
2  (1/505) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505)  (1/3) N/A
1  (1/61) N/A
2  (1/505)  (1/3) N/A
2  (5/505)  (1/3) N/A
2  (1/505) N/A
2  (6/505) N/A
2  (1/505) N/A
2  (1/503) N/A
2  (1/503) N/A
2  (1/505) N/A
2  (1/505) N/A
2  (1/505) N/A
1  (1/75) N/A
2  (1/503) N/A
2  (1/505)  (1/3) N/A
1  (1/72) N/A
2  (1/505) N/A
2  (1/505) N/A

 Associated Images

X-ray: XRay Images Forepaw
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
Sleep Wake: Wake state (bmp file)
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
Original Image
Adult LacZ: LacZ Images Section
12 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
Electroretinography: Cone waveform (pdf format)
4 Images
Electroretinography: Rod waveform (pdf format)
4 Images

 Disease Models

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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cacna1stm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cacna1stm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Cacna1stm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice