Gene: Bmp4

Name
bone morphogenetic protein 4
MGI ID
MGI:88180
Synonyms
Bmp-4 Bmp2b-1 Bmp2b1 Bmp2b
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal optic disk morphology Bmp4tm1b(EUCOMM)Hmgu HET postnatal 7.74×10-08
abnormal heart morphology Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
abnormal hindbrain development Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
abnormal midbrain development Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
eyelids fail to open Bmp4tm1b(EUCOMM)Hmgu HET postnatal 8.67×10-06
embryonic growth retardation Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
microphthalmia Bmp4tm1b(EUCOMM)Hmgu HET embryonic day 12.5 0.00
abnormal neural tube closure Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
abnormal embryo turning Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
embryonic lethality prior to tooth bud stage Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 12.5 0.00
abnormal embryo size Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
abnormal tail morphology Bmp4tm1b(EUCOMM)Hmgu HET embryonic day 12.5 0.00
abnormal embryo development Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Bmp4tm1b(EUCOMM)Hmgu HOM n/a 0.00
abnormal forebrain development Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00
abnormal allantois morphology Bmp4tm1b(EUCOMM)Hmgu HOM embryonic day 9.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/383)  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No  (1/2)  Wholemount images
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  Wholemount images
Trachea 2 No N/A
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No N/A
Vas deferens 2 No  (15/388)  (1/2)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/47) N/A
Axial skeleton 2  (1/51) N/A
Brain 2  (6/485) N/A
Central nervous system ganglion 2  (1/51) N/A
Cranium 2  (1/46) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485) N/A
Outer ear 2  (1/47) N/A
Eye 2  (1/485) N/A
Femur pre-cartilage condensation 2  (1/46) N/A
Foot 2  (1/485) N/A
Forearm 2  (1/282) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 2  (1/48) N/A
Gut 2  (1/50) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Head mesenchyme 2  (1/47) N/A
Heart 2  (1/485) N/A
Heart ventricle 2  (1/47) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Humerus pre-cartilage condensation 2  (1/46) N/A
Inner ear 2  (1/46) N/A
Intestine 2  (1/47) N/A
Liver 2  (1/485) N/A
Lower leg 2  (1/282) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Mesonephros of female 2  (1/46) N/A
Mesonephros of male 2  (1/46) N/A
Metanephros 2  (1/46) N/A
Midbrain 2  (1/485) N/A
Nasal septum 2  (1/47) N/A
Nose 2  (1/51) N/A
Notochord 2  (1/47) N/A
Oral cavity 2  (1/485) N/A
Outflow tract 2  (1/47) N/A
Pancreas 2  (1/46) N/A
Pericardium 2  (1/46) N/A
Pharynx 2  (1/46) N/A
Radius-ulna pre-cartilage condensation 2  (1/46) N/A
Rib pre-cartilage condensation 2  (1/46) N/A
Skeleton 2  (1/51) N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50) N/A
Stomach 2  (1/46) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A
Thoracic vertebral cartilage condensation 2  (1/46) N/A
Tongue 2  (1/46) N/A
Trachea 2  (1/50) N/A
Trunk mesenchyme 2  (1/47) N/A
Umbilical artery embryonic part 2  (1/47) N/A
Umbilical vein embryonic part 2  (1/47) N/A
Upper arm 2  (1/282) N/A
Upper leg 2  (1/282) N/A
Urinary system 2  (1/50) N/A
Vibrissa 2  (1/47) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
16 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Bmp4tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Bmp4tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice, Tissue