Gene Summary

bone morphogenetic protein 1

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal body wall morphology Bmp1em1(IMPC)Bay HOM E18.5 0.00
preweaning lethality, complete penetrance Bmp1em1(IMPC)Bay HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bmp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Bmp1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Osteogenesis Imperfecta, Type Xiii
Dentinogenesis imperfecta, Umbilical hernia OMIM:614856

The table below shows human diseases predicted to be associated to Bmp1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Abdominal wall defect, Gastroschisis OMIM:230750
Volvulus, Intestinal malrotation, Intestinal atresia, Intestinal perforation, Gastroschisis ORPHA:2368
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Gastroschisis, Ectopic anus, Spina bifida, Anencephaly, Cleft palate ORPHA:2476
Colonic Atresia
Peptic ulcer, Colonic atresia, Duodenal stenosis, Omphalocele, Gastroschisis ORPHA:1198
Secondary Short Bowel Syndrome
Volvulus, Villous atrophy, Abnormal small intestine morphology, Aganglionic megacolon, Small inte... ORPHA:95427
Visceral Myopathy 2
Barrett esophagus, Gastroesophageal reflux, Volvulus, Intestinal pseudo-obstruction, Intestinal m... OMIM:619350
Hypoglossia-Hypodactyly Syndrome
Hypoplasia of the zygomatic bone, Aplasia/Hypoplasia of the tongue, Micrognathia, Death in infanc... ORPHA:989
Spinal dysraphism, Myelomeningocele, Encephalocele, Spina bifida, Mandibular aplasia, Omphalocele... ORPHA:63259
Gm1 Gangliosidosis
Gastroesophageal reflux, Inguinal hernia, Aplasia/Hypoplasia of the abdominal wall musculature, D... ORPHA:354
Constricting Bands, Congenital
Encephalocele, Gastroschisis, Omphalocele, Bladder exstrophy, Cleft palate OMIM:217100
Duplication Of Urethra
Rectourethral fistula, Anorectal anomaly, Anal fistula, Anal atresia, Gastroschisis ORPHA:237
Acrofacial Dysostosis 1, Nager Type
Retrognathia, Velopharyngeal insufficiency, Temporomandibular joint ankylosis, Micrognathia, Agan... OMIM:154400
Frontonasal Dysplasia-Severe Microphthalmia-Severe Facial Clefting Syndrome
Hypoplasia of the maxilla, Cranium bifidum occultum, Hypoplasia of the frontal bone, Cleft palate ORPHA:306542
Frontofacionasal Dysplasia
Bifid uvula, Cranium bifidum occultum, Hypoplasia of the frontal bone OMIM:229400
Smith-Lemli-Opitz Syndrome
Gastroesophageal reflux, Microglossia, Abnormal dental enamel morphology, Micrognathia, Advanced ... ORPHA:818
Isolated Exencephaly
Hypoplasia of the frontal bone ORPHA:563612
Necrotizing Enterocolitis
Gastroschisis ORPHA:391673
Tetraamelia Syndrome 1
Anal atresia, Micrognathia, Cleft palate, Gastroschisis OMIM:273395
Hartsfield Syndrome
Hypoplasia of the frontal bone, Cleft palate OMIM:615465
Osteogenesis Imperfecta, Type Xiii
Dentinogenesis imperfecta, Umbilical hernia OMIM:614856


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bmp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bmp1.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Warning regarding hematological toxicity of tamoxifen activated CreERT2 in young Rosa26CreERT2 mice. Scientific reports (April 2023) Bmp10tm3c(EUCOMM)Hmgu PMC10097815
Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10. Cardiovascular research (June 2022) Bmp10tm3c(EUCOMM)Hmgu PMC9215199
BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer. Journal of experimental & clinical cancer research : CR (August 2018) Bmp10tm3c(EUCOMM)Hmgu PMC6118004
Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of molecular histology (December 2016) Bmp1tm1a(KOMP)Wtsi PMC6635762

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Bmp1em1(IMPC)Bay Exon Deletion Mice
Bmp1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bmp1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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