Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Bmp1 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Osteogenesis Imperfecta, Type Xiii | Dentinogenesis imperfecta, Umbilical hernia | OMIM:614856 |
The table below shows human diseases predicted to be associated to Bmp1 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bmp1.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Warning regarding hematological toxicity of tamoxifen activated CreERT2 in young Rosa26CreERT2 mice. | Scientific reports (April 2023) | Bmp10tm3c(EUCOMM)Hmgu | PMC10097815 |
Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10. | Cardiovascular research (June 2022) | Bmp10tm3c(EUCOMM)Hmgu | PMC9215199 |
BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer. | Journal of experimental & clinical cancer research : CR (August 2018) | Bmp10tm3c(EUCOMM)Hmgu | PMC6118004 |
Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. | Journal of molecular histology (December 2016) | Bmp1tm1a(KOMP)Wtsi | PMC6635762 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Bmp1em1(IMPC)Bay | Exon Deletion | Mice |
Bmp1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Bmp1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
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