Gene Summary

bone morphogenetic protein 1

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal body wall morphology Bmp1em1(IMPC)Bay HOM E18.5 0.00
preweaning lethality, complete penetrance Bmp1em1(IMPC)Bay HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bmp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Bmp1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Osteogenesis Imperfecta, Type Xiii
Umbilical hernia OMIM:614856

The table below shows human diseases predicted to be associated to Bmp1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Intestinal atresia, Gastroschisis ORPHA:2368
Gastroschisis, Abdominal wall defect OMIM:230750
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Ectopic anus, Cleft palate, Anencephaly, Spina bifida, Gastroschisis ORPHA:2476
Colonic Atresia
Peptic ulcer, Colonic atresia, Omphalocele, Duodenal stenosis, Gastroschisis ORPHA:1198
Secondary Short Bowel Syndrome
Malabsorption, Enterocolitis, Intestinal atresia, Steatorrhea, Small intestinal dysmotility, Volv... ORPHA:95427
Hypoglossia-Hypodactyly Syndrome
High palate, Anal atresia, Aplasia/Hypoplasia of the tongue, Cleft palate, Micrognathia, Hypoplas... ORPHA:989
Myelomeningocele, Anal atresia, Duodenal atresia, Anencephaly, Spinal dysraphism, Mandibular apla... ORPHA:63259
Gm1 Gangliosidosis
Gastroesophageal reflux, Inguinal hernia, Macroglossia, Aplasia/Hypoplasia of the abdominal wall ... ORPHA:354
Constricting Bands, Congenital
Cleft palate, Bladder exstrophy, Omphalocele, Encephalocele, Gastroschisis OMIM:217100
Acrofacial Dysostosis 1, Nager Type
Velopharyngeal insufficiency, Cleft palate, Retrognathia, Micrognathia, Trismus, Aganglionic mega... OMIM:154400
Necrotizing Enterocolitis
Gastroschisis ORPHA:391673
Frontonasal Dysplasia-Severe Microphthalmia-Severe Facial Clefting Syndrome
Cranium bifidum occultum, Hypoplasia of the maxilla, Hypoplasia of the frontal bone, Cleft palate ORPHA:306542
Duplication Of Urethra
Anal atresia, Anal fistula, Rectourethral fistula, Anorectal anomaly, Gastroschisis ORPHA:237
Smith-Lemli-Opitz Syndrome
Abnormal dental enamel morphology, Supernumerary tooth, Gastroesophageal reflux, Cleft palate, Mi... ORPHA:818
Isolated Exencephaly
Hypoplasia of the frontal bone ORPHA:563612
Frontofacionasal Dysplasia
Bifid uvula, Cranium bifidum occultum, Hypoplasia of the frontal bone OMIM:229400
Tetraamelia Syndrome 1
Anal atresia, Micrognathia, Cleft palate, Gastroschisis OMIM:273395
Hartsfield Syndrome
Hypoplasia of the frontal bone, Cleft palate OMIM:615465
Osteogenesis Imperfecta, Type Xiii
Umbilical hernia OMIM:614856


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bmp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bmp1.

No publications found that use IMPC mice or data for Bmp1.

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MGI Allele Allele Type Produced
Bmp1em1(IMPC)Bay Exon Deletion Mice
Bmp1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bmp1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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