Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

bone morphogenetic protein 1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bmp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Bmp1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source
Osteogenesis Imperfecta, Type Xiii
Umbilical hernia OMIM:614856

The table below shows human diseases predicted to be associated to Bmp1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Gastroschisis, Intestinal atresia ORPHA:2368
Gastroschisis, Abdominal wall defect OMIM:230750
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Gastroschisis, Ectopic anus, Spina bifida, Cleft palate ORPHA:2476
Colonic Atresia
Colonic atresia, Omphalocele, Gastroschisis, Peptic ulcer, Duodenal stenosis ORPHA:1198
Secondary Short Bowel Syndrome
Small intestinal dysmotility, Villous atrophy, Aganglionic megacolon, Steatorrhea, Gastroschisis,... ORPHA:95427
Hypoglossia-Hypodactyly Syndrome
Death in infancy, Aplasia/Hypoplasia of the tongue, Jejunal atresia, Gastroschisis, Anal atresia,... ORPHA:989
Visceral Myopathy 2
Megaduodenum, Hiatus hernia, Esophagitis, Dysphagia, Gastroesophageal reflux, Intestinal malrotat... OMIM:619350
Mandibular aplasia, Spina bifida, Spinal dysraphism, Omphalocele, Gastroschisis, Duodenal atresia... ORPHA:63259
Gm1 Gangliosidosis
Macroglossia, Dysphagia, Mandibular prognathia, Gastroesophageal reflux, Gastroschisis, Inguinal ... ORPHA:354
Acrofacial Dysostosis 1, Nager Type
Aganglionic megacolon, Trismus, Gastroschisis, Cleft palate, Retrognathia, Micrognathia, Velophar... OMIM:154400
Constricting Bands, Congenital
Gastroschisis, Omphalocele, Bladder exstrophy, Cleft palate OMIM:217100
Isolated Exencephaly
Hypoplasia of the frontal bone ORPHA:563612
Necrotizing Enterocolitis
Gastroschisis ORPHA:391673
Smith-Lemli-Opitz Syndrome
Abnormal dental enamel morphology, Micrognathia, Gastroesophageal reflux, Aganglionic megacolon, ... ORPHA:818
Hartsfield Syndrome
Hypoplasia of the frontal bone, Cleft palate OMIM:615465
Frontonasal Dysplasia-Severe Microphthalmia-Severe Facial Clefting Syndrome
Hypoplasia of the maxilla, Hypoplasia of the frontal bone, Cleft palate ORPHA:306542
Tetraamelia Syndrome 1
Gastroschisis, Anal atresia, Micrognathia, Cleft palate OMIM:273395
Duplication Of Urethra
Rectourethral fistula, Gastroschisis, Anal atresia, Anorectal anomaly, Anal fistula ORPHA:237
Frontofacionasal Dysplasia
Bifid uvula, Hypoplasia of the frontal bone OMIM:229400
Osteogenesis Imperfecta, Type Xiii
Umbilical hernia OMIM:614856


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bmp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bmp1.

No publications found that use IMPC mice or data for Bmp1.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Bmp1em1(IMPC)Bay Exon Deletion Mice
Bmp1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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