Aprt | adenine phosphoribosyl transferase

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Vision/eye Mortality/aging

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:3Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal retina morphology1 supporting datasetAprtem1(IMPC)HmguhomozygoteEarly adult9.53x10-7 
preweaning lethality, incomplete penetrance1 supporting datasetAprtem1(IMPC)HmguhomozygoteEarly adultN/A * 
increased respiratory quotient1 supporting datasetAprtem1(IMPC)HmguheterozygoteEarly adult4.94x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Aprtem1(IMPC)HmguExon Deletionmouse
Aprttm1(KOMP)MbpReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell

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