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Gene: Adh1 MGI:87921

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

alcohol dehydrogenase 1 (class I)

Synonyms:

Adh1-t, ADH-AA, Adh1tl, class I alcohol dehydrogenase, Adh-1, Adh-1e, Adh-1-t, Adh1-e, Adh-1t

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Adh1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Adh1 (2 diseases)
Human diseases predicted to be associated with Adh1 (388 diseases)

The table below shows human diseases associated to Adh1 by orthology or direct annotation.

Disease	Similarity of phenotypes	Matching phenotypes	Source
Alcohol Dependence			OMIM:103780
Parkinson Disease, Late-Onset			OMIM:168600

The table below shows human diseases predicted to be associated to Adh1 by phenotypic similarity.

Disease	Matching phenotypes	Source
Carpal Tunnel Syndrome 1	Reduced circulating vitamin B6 level	OMIM:115430
Fructosuria, Essential	Impairment of fructose metabolism	OMIM:229800
Osteoporosis, Juvenile	Low serum calcitriol	OMIM:259750
Tuberculosis	Weight loss	ORPHA:3389
Pulmonary Blastoma	Weight loss	ORPHA:64741
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency	Abnormal circulating vitamin E concentration, Abnormal circulating vitamin A concentration, Obesity	ORPHA:209902
Galactose Epimerase Deficiency	Impairment of galactose metabolism, Weight loss	ORPHA:79238
Pancreatic Triacylglycerol Lipase Deficiency	Decreased circulating vitamin E concentration, Weight loss, Reduced circulating vitamin A concent...	ORPHA:309031
Mantle Cell Lymphoma	Weight loss	ORPHA:52416
Hypercholanemia, Familial, 2	Low levels of vitamin D	OMIM:619256
Diamond-Blackfan Anemia 9	Low levels of vitamin D	OMIM:613308
Progressive Nodular Histiocytosis	Cachexia	ORPHA:158022
Pernicious Anemia	Malabsorption of Vitamin B12	OMIM:170900
Idiopathic Achalasia	Weight loss	ORPHA:930
Maternal Uniparental Disomy Of Chromosome 4	Reduced circulating vitamin A concentration, Decreased circulating vitamin E concentration, Low l...	ORPHA:96180
Autosomal Recessive Cerebellar Ataxia With Late-Onset Spasticity	Reduced circulating vitamin A concentration, Decreased circulating vitamin E concentration	ORPHA:352641
Hypercholanemia, Familial 1	Failure to thrive, Low levels of vitamin K	OMIM:607748
Imerslund-Grasbeck Syndrome 1	Malabsorption of Vitamin B12, Vitamin B12 deficiency, Abnormal blood folate concentration	OMIM:261100
Autosomal Dominant Congenital Benign Spinal Muscular Atrophy	Cachexia	ORPHA:1216
Undifferentiated Pleomorphic Sarcoma	Weight loss	ORPHA:2023
Isolated Congenital Hypoglossia/Aglossia	Weight loss	ORPHA:141152
Formiminoglutamic Aciduria	Increased blood folate concentration, Abnormality of folate metabolism	ORPHA:51208
Chronic Hiccup	Weight loss	ORPHA:396
Isaacs Syndrome	Weight loss	ORPHA:84142
Arthrogryposis-Like Hand Anomaly-Sensorineural Deafness Syndrome	Cachexia	ORPHA:1144
Intestinal Dysmotility Syndrome	Failure to thrive, Weight loss	OMIM:620045
Mulibrey Nanism	Cachexia	ORPHA:2576
Huntington Disease-Like 2	Weight loss	ORPHA:98934
Multicentric Reticulohistiocytosis	Cachexia	ORPHA:139436
Imerslund-Grasbeck Syndrome 2	Vitamin B12 deficiency	OMIM:618882
Diarrhea 6	Vitamin B12 deficiency	OMIM:614616
Mitochondrial Dna Depletion Syndrome 8A (Encephalomyopathic Type With Renal Tubulopathy)	Failure to thrive, Cachexia, Weight loss	OMIM:612075
Laryngeal Neuroendocrine Tumor	Weight loss	ORPHA:100083
Vitamin D-Dependent Rickets, Type 3	Low serum calcitriol, Decreased circulating calcifediol concentration	OMIM:619073
Primary Sclerosing Cholangitis	Decreased circulating vitamin E concentration, Weight loss, Reduced circulating vitamin A concent...	ORPHA:171
Abetalipoproteinemia	Reduced circulating vitamin A concentration, Low levels of vitamin D, Decreased circulating vitam...	ORPHA:14
Mitochondrial Dna Depletion Syndrome 4B (Mngie Type)	Slender build, Cachexia, Weight loss	OMIM:613662
Shwachman-Diamond Syndrome	Decreased circulating vitamin E concentration, Reduced circulating vitamin A concentration, Low l...	ORPHA:811
Diencephalic Syndrome	Cachexia, Decreased body weight	ORPHA:1672
Insulin Autoimmune Syndrome	Weight loss	ORPHA:411593
Inflammatory Bowel Disease 11	Weight loss	OMIM:191390
Acute Myelomonocytic Leukemia	Weight loss	ORPHA:517
Obesity Due To Sim1 Deficiency	Low levels of vitamin B1, Obesity	ORPHA:369873
Moynahan Syndrome	Cachexia	ORPHA:2574
Nodular Lymphocyte Predominant Hodgkin Lymphoma	Weight loss	ORPHA:86893
Focal Myositis	Weight loss	ORPHA:48918
Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome	Weight loss	ORPHA:2198
Hereditary Central Diabetes Insipidus	Weight loss	ORPHA:30925
Huntington Disease-Like 2	Weight loss	OMIM:606438
Secondary Short Bowel Syndrome	Failure to thrive, Abnormality of vitamin metabolism, Weight loss	ORPHA:95427
Riboflavin Deficiency	Low levels of vitamin B2	OMIM:615026
Intrinsic Factor Deficiency	Malabsorption of Vitamin B12, Vitamin B12 deficiency	OMIM:261000
Acquired Central Diabetes Insipidus	Weight loss	ORPHA:95626
Bile Acid Malabsorption, Primary, 2	Low levels of vitamin D, Decreased circulating vitamin E concentration	OMIM:619481
Central Diabetes Insipidus	Failure to thrive, Weight loss	ORPHA:178029
Reticular Dysgenesis	Failure to thrive, Weight loss	ORPHA:33355
Mast Cell Sarcoma	Weight loss	ORPHA:66661
Mu-Heavy Chain Disease	Weight loss	ORPHA:100024
Autosomal Recessive Polycystic Kidney Disease	Reduced circulating vitamin A concentration, Low levels of vitamin D, Decreased circulating vitam...	ORPHA:731
Bile Acid Synthesis Defect, Congenital, 4	Failure to thrive, Decreased circulating calcifediol concentration, Decreased circulating vitamin...	OMIM:214950
Attrv30M Amyloidosis	Weight loss	ORPHA:85447
Imerslund-Gräsbeck Syndrome	Vitamin B12 deficiency, Abnormal blood 5-methyltetrahydrofolate level, Weight loss, Malabsorption...	ORPHA:35858
Primary Intestinal Lymphangiectasia	Low levels of vitamin D, Abnormality of vitamin metabolism, Weight loss	ORPHA:90362
Chylomicron Retention Disease	Failure to thrive, Abnormality of vitamin metabolism	ORPHA:71
Hypercalcemia, Infantile, 1	Failure to thrive, Weight loss	OMIM:143880
Perry Syndrome	Weight loss	ORPHA:178509
Follicular Lymphoma	Weight loss	ORPHA:545
Pomgnt2-Related Limb-Girdle Muscular Dystrophy R24	Low levels of vitamin K	ORPHA:565899
Generalized Eruptive Histiocytosis	Abnormal vitamin B12 level	ORPHA:157991
Hirschsprung Disease	Failure to thrive in infancy, Weight loss	ORPHA:388
Inflammatory Bowel Disease (Crohn Disease) 1	Weight loss	OMIM:266600
Erythrokeratodermia Variabilis	Weight loss	ORPHA:317
Alexander Disease Type I	Failure to thrive, Cachexia	ORPHA:363717
Juvenile Huntington Disease	Weight loss	ORPHA:248111
Allergic Bronchopulmonary Aspergillosis	Weight loss	ORPHA:1164
Pleural Mesothelioma	Weight loss	ORPHA:50251
Oculopharyngodistal Myopathy	Weight loss	ORPHA:98897
Pseudomyxoma Peritonei	Weight loss	ORPHA:26790
Pfapa Syndrome	Weight loss	ORPHA:42642
Liposarcoma	Weight loss	ORPHA:69078
Congenital Muscular Dystrophy Due To Lmna Mutation	Cachexia	ORPHA:157973
Parkinson Disease 4, Autosomal Dominant	Weight loss	OMIM:605543
Autosomal Dominant Epidermolytic Ichthyosis	Weight loss	ORPHA:312
Congenital Bile Acid Synthesis Defect Type 3	Abnormality of vitamin metabolism	ORPHA:79302
Spinocerebellar Ataxia 48	Cachexia	OMIM:618093
Celiac Disease, Susceptibility To, 1	Vitamin B12 deficiency, Weight loss, Reduced blood folate concentration, Low levels of vitamin D,...	OMIM:212750
Cap Polyposis	Weight loss	ORPHA:160148
Maxillonasal Dysplasia	Low levels of vitamin K	ORPHA:1248
Bullous Pemphigoid	Weight loss	ORPHA:703
Bile Acid Synthesis Defect, Congenital, 6	Low levels of vitamin D	OMIM:617308
Peritoneal Cystic Mesothelioma	Weight loss	ORPHA:168816
Cortical Blindness-Intellectual Disability-Polydactyly Syndrome	Cachexia	ORPHA:1389
Thyrotoxic Periodic Paralysis, Susceptibility To, 1	Weight loss	OMIM:188580
Malignant Peritoneal Mesothelioma	Weight loss	ORPHA:168811
Congenital Enterocyte Heparan Sulfate Deficiency	Weight loss	ORPHA:103910
Osteosarcoma	Weight loss	ORPHA:668
Mcdonough Syndrome	Cachexia	ORPHA:2471
Pemphigus Vulgaris	Weight loss	ORPHA:704
Graves Disease, Susceptibility To, 1	Weight loss	OMIM:275000
Thymic Carcinoma	Weight loss	ORPHA:99868
Bone Dysplasia, Lethal Holmgren Type	Failure to thrive, Weight loss	ORPHA:1842
Rhabdoid Tumor	Weight loss	ORPHA:69077
Thyrotoxic Periodic Paralysis, Susceptibility To, 2	Weight loss	OMIM:613239
Huntington Disease	Decreased body mass index, Weight loss	ORPHA:399
Osteoporosis-Pseudoglioma Syndrome	Low serum calcitriol	ORPHA:2788
Desmoplastic Small Round Cell Tumor	Cachexia, Weight loss	ORPHA:83469
Hypophosphatemic Rickets With Hypercalciuria, Hereditary	High serum calcitriol, Failure to thrive, High serum calcifediol	OMIM:241530
Acquired Hypertrichosis Lanuginosa	Weight loss	ORPHA:2221
Mitochondrial Neurogastrointestinal Encephalomyopathy	Cachexia, Weight loss	ORPHA:298
Lipodystrophy Due To Peptidic Growth Factors Deficiency	Cachexia, Weight loss	ORPHA:1979
Christianson Syndrome	Cachexia	ORPHA:85278
Huntington Disease-Like 1	Weight loss	ORPHA:157941
Immunodeficiency 27A	Weight loss	OMIM:209950
Benign Recurrent Intrahepatic Cholestasis	Weight loss	ORPHA:65682
Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies 2	Failure to thrive in infancy, Cachexia	OMIM:616801
Refractory Celiac Disease	Low serum calcitriol, Weight loss	ORPHA:398063
Eosinophilic Fasciitis	Weight loss	ORPHA:3165
Riboflavin Transporter Deficiency	Cachexia	ORPHA:97229
Lead Poisoning	Low levels of vitamin D, Small for gestational age, Abnormality of vitamin D metabolism	ORPHA:330015
Classic Hodgkin Lymphoma	Weight loss	ORPHA:391
Isolated Succinate-Coq Reductase Deficiency	Weight loss	ORPHA:3208
Vitamin D Hydroxylation-Deficient Rickets, Type 1B	Failure to thrive, Decreased circulating calcifediol concentration	OMIM:600081
Deafness-Hypogonadism Syndrome	Low levels of vitamin B1	ORPHA:90646
Nephroblastoma	Weight loss	ORPHA:654
Chronic Beryllium Disease	Weight loss	ORPHA:133
Vitamin D Hydroxylation-Deficient Rickets, Type 1A	Low serum calcitriol, Failure to thrive, Decreased circulating calcifediol concentration	OMIM:264700
Takayasu Arteritis	Weight loss	ORPHA:3287
Idiopathic Bronchiectasis	Cachexia	ORPHA:60033
Non-Functioning Paraganglioma	Weight loss	ORPHA:94080
Glucose-Galactose Malabsorption	Failure to thrive, Weight loss	ORPHA:35710
Renpenning Syndrome	Cachexia	ORPHA:3242
Rnf13-Related Severe Early-Onset Epileptic Encephalopathy	Abnormal vitamin B12 level, Failure to thrive	ORPHA:544503
Classic Galactosemia	Low levels of vitamin D	ORPHA:79239
Kaposi Sarcoma	Weight loss	ORPHA:33276
Wilson Disease	Failure to thrive, Increased body weight, Weight loss	ORPHA:905
X-Linked Agammaglobulinemia	Failure to thrive, Weight loss	ORPHA:47
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency	Abnormal blood folate concentration, Decreased CSF 5-methyltetrahydrofolate concentration	OMIM:613839
Polyarteritis Nodosa	Weight loss	ORPHA:767
Pulmonary Non-Tuberculous Mycobacterial Infection	Weight loss	ORPHA:411703
Leishmaniasis	Weight loss	ORPHA:507
Majeed Syndrome	Failure to thrive, Cachexia, Weight loss	ORPHA:77297
Congenital Bile Acid Synthesis Defect Type 2	Failure to thrive, Decreased circulating vitamin E concentration	ORPHA:79303
Marchiafava-Bignami Disease	Low levels of vitamin B1	ORPHA:221074
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor	High serum calcitriol	OMIM:600785
Mitochondrial Dna Depletion Syndrome, Encephalomyopathic Form With Methylmalonic Aciduria	Cachexia	ORPHA:1933
Generalized Pseudohypoaldosteronism Type 1	Failure to thrive in infancy, Weight loss	ORPHA:171876
Flynn-Aird Syndrome	Cachexia	ORPHA:2047
Classic Pantothenate Kinase-Associated Neurodegeneration	Weight loss	ORPHA:216866
Laryngotracheoesophageal Cleft Type 4	Cachexia	ORPHA:93941
Subcutaneous Panniculitis-Like T-Cell Lymphoma	Weight loss	ORPHA:86884
Ring Chromosome 10 Syndrome	Cachexia	ORPHA:1438
Holocarboxylase Synthetase Deficiency	Weight loss	ORPHA:79242
Methylmalonic Aciduria, Cbla Type	Methylmalonic acidemia, Abnormal vitamin B12 level, Failure to thrive, Decreased adenosylcobalamin	OMIM:251100
Anaplastic Thyroid Carcinoma	Weight loss	ORPHA:142
Deafness-Lymphedema-Leukemia Syndrome	Weight loss	ORPHA:3226
Yao Syndrome	Weight loss	OMIM:617321
Respiratory Bronchiolitis-Interstitial Lung Disease Syndrome	Weight loss	ORPHA:79127
Vitamin D-Dependent Rickets, Type 2A	High serum calcitriol, Failure to thrive	OMIM:277440
Medullary Thyroid Carcinoma	Weight loss	ORPHA:1332
Tetrasomy 12P	Cachexia	ORPHA:884
Autosomal Dominant Hypophosphatemic Rickets	Low levels of vitamin D	ORPHA:89937
Rheumatoid Arthritis	Weight loss	OMIM:180300
Congenital Disorder Of Glycosylation, Type Iit	Low levels of vitamin D, Abnormal protein O-linked glycosylation	OMIM:618885
Hypobetalipoproteinemia, Familial, 1	Decreased circulating vitamin E concentration	OMIM:615558
Multicentric Carpo-Tarsal Osteolysis With Or Without Nephropathy	Cachexia	ORPHA:2774
Cryptogenic Organizing Pneumonia	Weight loss	ORPHA:1302
Fatal Familial Insomnia	Weight loss	OMIM:600072
Perry Syndrome	Weight loss	OMIM:168605
Oromandibular Dystonia	Weight loss	ORPHA:93958
Hypotonia-Speech Impairment-Severe Cognitive Delay Syndrome	Severe failure to thrive, Cachexia	ORPHA:371364
Klatskin Tumor	Weight loss	ORPHA:99978
Hyperprolinemia Type 2	Reduced circulating vitamin B6 level	ORPHA:79101
Medium Chain Acyl-Coa Dehydrogenase Deficiency	Cachexia	ORPHA:42
Cronkhite-Canada Syndrome	Cachexia	ORPHA:2930
Eosinophilic Gastroenteritis	Weight loss	ORPHA:2070
Wolman Disease	Cachexia	ORPHA:75233
Pelizaeus-Merzbacher Disease	Failure to thrive in infancy, Cachexia	ORPHA:702
Inflammatory Pseudotumor Of The Liver	Weight loss	ORPHA:90003
Idiopathic Chronic Eosinophilic Pneumonia	Weight loss	ORPHA:2902
Neuroblastoma, Susceptibility To, 1	Failure to thrive, Weight loss	OMIM:256700
Congenital Tufting Enteropathy	Failure to thrive, Weight loss	ORPHA:92050
Neuropathy, Congenital Hypomyelinating, 3	Cachexia	OMIM:618186
Wild Type Attr Amyloidosis	Weight loss	ORPHA:330001
Igg4-Related Aortitis	Weight loss	ORPHA:449400
Ménétrier Disease	Weight loss	ORPHA:2494
Loeffler Endocarditis	Weight loss	ORPHA:75566
Congenital Bile Acid Synthesis Defect Type 4	Low levels of vitamin K	ORPHA:79095
Diffuse Alveolar Hemorrhage	Weight loss	ORPHA:90060
Gm1 Gangliosidosis	Failure to thrive, Weight loss	ORPHA:354
Acute Monoblastic/Monocytic Leukemia	Weight loss	ORPHA:514
Carney-Stratakis Syndrome	Weight loss	ORPHA:97286
Familial Hyperthyroidism Due To Mutations In Tsh Receptor	Small for gestational age, Weight loss	ORPHA:424
Nodular Non-Suppurative Panniculitis	Weight loss	ORPHA:33577
Fanconi Renotubular Syndrome 2	High serum calcitriol	OMIM:613388
Oculogastrointestinal Muscular Dystrophy	Cachexia	ORPHA:1876
Eiken Syndrome	Low levels of vitamin D, Decreased body weight	OMIM:600002
Aggressive Systemic Mastocytosis	Weight loss	ORPHA:98850
Aredyld Syndrome	Cachexia	ORPHA:1133
Bone Marrow Failure Syndrome 3	Failure to thrive, Low levels of vitamin D, Decreased circulating vitamin E concentration	OMIM:617052
Corticosteroid-Sensitive Aseptic Abscess Syndrome	Weight loss	ORPHA:54251
Hereditary Hypophosphatemic Rickets With Hypercalciuria	High serum calcitriol	ORPHA:157215
Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis	Weight loss	ORPHA:324964
Pneumocystosis	Weight loss	ORPHA:723
Hypocalcemic Vitamin D-Dependent Rickets	Low serum calcitriol, Failure to thrive	ORPHA:289157
Transcobalamin Ii Deficiency	Failure to thrive, Abnormal blood folate concentration	OMIM:275350
Systemic Capillary Leak Syndrome	Weight loss	ORPHA:188
Growth Delay-Intellectual Disability-Hepatopathy Syndrome	Abnormality of vitamin D metabolism	ORPHA:541423
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3	High serum calcitriol	OMIM:617994
Felty Syndrome	Weight loss	ORPHA:47612
Thymic Neuroendocrine Tumor	Weight loss	ORPHA:97289
19Q13.11 Microdeletion Syndrome	Failure to thrive, Cachexia	ORPHA:217346
Infantile Nephropathic Cystinosis	Failure to thrive, Abnormality of vitamin D metabolism	ORPHA:411629
Short Syndrome	Weight loss	ORPHA:3163
Polymyositis	Weight loss	ORPHA:732
8P23.1 Microdeletion Syndrome	Obesity, Weight loss	ORPHA:251071
Xeroderma Pigmentosum-Cockayne Syndrome Complex	Abnormality of amino acid metabolism, Cachexia	ORPHA:220295
Multiple Myeloma	Weight loss, Abnormality of vitamin B12 metabolism	ORPHA:29073
Tumoral Calcinosis, Hyperphosphatemic, Familial, 1	High serum calcitriol	OMIM:211900
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form	Low levels of vitamin D, Failure to thrive, Decreased body weight	ORPHA:89842
Aicardi-Goutieres Syndrome 9	Failure to thrive, Weight loss	OMIM:619487
Adrenocortical Carcinoma	Increased body weight, Weight loss	ORPHA:1501
Pyruvate Dehydrogenase E2 Deficiency	Low levels of vitamin B1	ORPHA:79244
Budd-Chiari Syndrome	Weight loss	ORPHA:131
X-Linked Creatine Transporter Deficiency	Cachexia	ORPHA:52503
Lymphoid Interstitial Pneumonia	Failure to thrive, Weight loss	ORPHA:79128
Silver-Russell Syndrome	Failure to thrive in infancy, Obesity, Cachexia	ORPHA:813
Dietary Iron Overload Disease	Low levels of vitamin C	ORPHA:139507
Symptomatic Form Of Hfe-Related Hemochromatosis	Weight loss	ORPHA:465508
Acrodermatitis Enteropathica	Failure to thrive, Weight loss	ORPHA:37
Neuroendocrine Tumor Of The Colon	Weight loss	ORPHA:100080
Solitary Fibrous Tumor	Weight loss	ORPHA:2126
Fryns-Smeets-Thiry Syndrome	Cachexia	ORPHA:2058
Osteootohepatoenteric Syndrome	Failure to thrive, Weight loss	OMIM:619377
Acute Promyelocytic Leukemia	Weight loss	ORPHA:520
Familial Glucocorticoid Deficiency	Failure to thrive, Weight loss	ORPHA:361
Primary Myelofibrosis	Cachexia	ORPHA:824
Gerstmann-Straussler Disease	Weight loss	OMIM:137440
Sporadic Pheochromocytoma/Secreting Paraganglioma	Weight loss	ORPHA:276621
Hypophosphatemic Rickets, X-Linked Recessive	High serum calcitriol	OMIM:300554
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type)	Slender build, Cachexia, Weight loss	OMIM:603041
Drug Reaction With Eosinophilia And Systemic Symptoms	Weight loss	ORPHA:139402
Glossopharyngeal Neuralgia	Weight loss	ORPHA:221098
Diamond-Blackfan Anemia 7	Low levels of vitamin D	OMIM:612562
Infantile Krabbe Disease	Failure to thrive, Cachexia	ORPHA:206436
Eosinophilic Granulomatosis With Polyangiitis	Weight loss	ORPHA:183
Rett Syndrome	Cachexia	OMIM:312750
Pancreatoblastoma	Weight loss	ORPHA:677
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes	Cachexia	OMIM:175500
Familial Gestational Hyperthyroidism	Weight loss	ORPHA:99819
Bronchial Neuroendocrine Tumor	Weight loss	ORPHA:97287
Neuroendocrine Tumor Of The Rectum	Weight loss	ORPHA:100081
Neuroendocrine Tumor Of Anal Canal	Weight loss	ORPHA:100082
Beta-Ketothiolase Deficiency	Weight loss	ORPHA:134
Giant Cell Arteritis	Weight loss	ORPHA:397
Peripheral Primitive Neuroectodermal Tumor	Weight loss	ORPHA:370348
Juvenile Amyotrophic Lateral Sclerosis	Cachexia	ORPHA:300605
Ataxia With Vitamin E Deficiency	Decreased circulating vitamin E concentration	OMIM:277460
Epidermal Nevus Syndrome	Low levels of vitamin D	ORPHA:35125
Dent Disease 1	High serum calcitriol	OMIM:300009
Late-Onset Isolated Acth Deficiency	Failure to thrive, Weight loss	ORPHA:199299
Thymoma	Weight loss	ORPHA:99867
Autoimmune Pulmonary Alveolar Proteinosis	Weight loss	ORPHA:747
X-Linked Intellectual Disability, Cabezas Type	Obesity, Cachexia	ORPHA:85293
Deafness-Small Bowel Diverticulosis-Neuropathy Syndrome	Cachexia	ORPHA:3217
Hereditary Amyloidosis With Primary Renal Involvement	Weight loss	ORPHA:85450
Cystic Echinococcosis	Weight loss	ORPHA:400
Primary Hepatic Neuroendocrine Carcinoma	Weight loss	ORPHA:100085
Amoebiasis Due To Entamoeba Histolytica	Weight loss	ORPHA:67
Pyomyositis	Weight loss	ORPHA:764
Poems Syndrome	Weight loss	ORPHA:2905
Chondrodysplasia Punctata, Autosomal Dominant	Low levels of vitamin K	OMIM:118650
Polycythemia Vera	Weight loss	ORPHA:729
X-Linked Alport Syndrome-Diffuse Leiomyomatosis	Failure to thrive, Weight loss	ORPHA:1018
Insulin-Resistance Syndrome Type B	Abnormality of body weight, Decreased body weight, Increased body weight, Weight loss	ORPHA:2298
3-Hydroxy-3-Methylglutaric Aciduria	Weight loss	ORPHA:20
Tropical Pancreatitis	Weight loss	ORPHA:103918
Al Amyloidosis	Weight loss	ORPHA:85443
Malignant Atrophic Papulosis	Weight loss	ORPHA:679
Xfe Progeroid Syndrome	Failure to thrive, Cachexia	OMIM:610965
Lynch Syndrome	Weight loss	ORPHA:144
Whipple Disease	Cachexia	ORPHA:3452
Hereditary Pheochromocytoma-Paraganglioma	Weight loss	ORPHA:29072
Autosomal Recessive Hypophosphatemic Rickets	Low serum calcitriol, Abnormality of vitamin D metabolism	ORPHA:289176
Familial Colorectal Cancer Type X	Weight loss	ORPHA:440437
Simple Cryoglobulinemia	Weight loss	ORPHA:91139
Systemic Mastocytosis With Associated Hematologic Neoplasm	Weight loss	ORPHA:98849
Gallbladder Neuroendocrine Tumor	Weight loss	ORPHA:100086
Familial Thrombocytosis	Weight loss	ORPHA:71493
Hereditary Late-Onset Parkinson Disease	Weight loss	ORPHA:411602
Sensory Ataxic Neuropathy, Dysarthria, And Ophthalmoparesis	Weight loss	OMIM:607459
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome	Decreased circulating vitamin E concentration, Abnormality of amino acid metabolism	ORPHA:309854
Lysosomal Acid Lipase Deficiency	Failure to thrive, Cachexia, Weight loss	ORPHA:275761
Anemia, Congenital Dyserythropoietic, Type Iv	Weight loss	OMIM:613673
Renal Nutcracker Syndrome	Weight loss	ORPHA:71273
Acute Adrenal Insufficiency	Failure to thrive, Weight loss	ORPHA:95409
Rajab Interstitial Lung Disease With Brain Calcifications 1	Low levels of vitamin D, Failure to thrive, Small for gestational age, Slender build	OMIM:613658
Granulomatosis With Polyangiitis	Weight loss	OMIM:608710
Juvenile Dermatomyositis	Weight loss	ORPHA:93672
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form	Low levels of vitamin D, Abnormality of vitamin metabolism	ORPHA:79408
Neuroendocrine Tumor Of Stomach	Weight loss	ORPHA:100075
Juvenile Nephropathic Cystinosis	Low levels of vitamin D, Failure to thrive	ORPHA:411634
Caroli Disease	Weight loss	ORPHA:53035
Q Fever	Weight loss	ORPHA:781
Igg4-Related Retroperitoneal Fibrosis	Weight loss	ORPHA:49041
Castleman Disease	Weight loss	ORPHA:160
Thyrotoxic Periodic Paralysis	Obesity, Weight loss	ORPHA:79102
Isolated Permanent Neonatal Diabetes Mellitus	Failure to thrive, Weight loss	ORPHA:99885
Familial Pancreatic Carcinoma	Weight loss	ORPHA:1333
Malt Lymphoma	Weight loss	ORPHA:52417
Alveolar Echinococcosis	Weight loss	ORPHA:284
Hermansky-Pudlak Syndrome	Weight loss	ORPHA:79430
Stevens-Johnson Syndrome	Weight loss	ORPHA:36426
Mucopolysaccharidosis Type 3	Low levels of vitamin D	ORPHA:581
Toxic Epidermal Necrolysis	Weight loss	ORPHA:537
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome	Failure to thrive in infancy, Cachexia	ORPHA:37042
Riddle Syndrome	Weight loss	ORPHA:420741
Erdheim-Chester Disease	Weight loss	ORPHA:35687
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib	Low levels of vitamin D, Failure to thrive	ORPHA:79259
Seckel Syndrome	Cachexia	ORPHA:808
Bannayan-Riley-Ruvalcaba Syndrome	Cachexia	ORPHA:109
Dent Disease	High serum calcitriol	ORPHA:1652
Mucolipidosis Type Ii	Weight loss	ORPHA:576
Microsporidiosis	Cachexia, Weight loss	ORPHA:2552
Trisomy 18	Cachexia	ORPHA:3380
Oculocerebrorenal Syndrome Of Lowe	Low levels of vitamin D, Failure to thrive	ORPHA:534
Immunodeficiency 31C	Weight loss	OMIM:614162
Schwartz-Jampel Syndrome	Cachexia, Decreased body weight	ORPHA:800
Congenital Fiber-Type Disproportion Myopathy	Failure to thrive, Weight loss	ORPHA:2020
Addison Disease	Failure to thrive, Weight loss	ORPHA:85138
Rat-Bite Fever	Weight loss	ORPHA:31205
Reactive Arthritis	Weight loss	ORPHA:29207
Facial Dysmorphism-Anorexia-Cachexia-Eye And Skin Anomalies Syndrome	Cachexia	ORPHA:1969
Oculopharyngodistal Myopathy 1	Weight loss	OMIM:164310
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis	Weight loss	ORPHA:85408
Ileal Neuroendocrine Tumor	Weight loss	ORPHA:100078
Aicardi-Goutieres Syndrome 7	Weight loss	OMIM:615846
Ppoma	Weight loss	ORPHA:97278
Brucellosis	Failure to thrive, Small for gestational age, Weight loss	ORPHA:1304
Fanconi Anemia	Weight loss	ORPHA:84
Tsh-Secreting Pituitary Adenoma	Weight loss	ORPHA:91347
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2	Weight loss	OMIM:301074
Somatostatinoma	Weight loss	ORPHA:97283
Cystinosis, Nephropathic	Failure to thrive in infancy, Weight loss	OMIM:219800
Parathyroid Carcinoma	Weight loss	ORPHA:143
Granulomatosis With Polyangiitis	Weight loss	ORPHA:900
Zollinger-Ellison Syndrome	Weight loss	ORPHA:913
Grfoma	Weight loss	ORPHA:97261
Vipoma	Weight loss	ORPHA:97282
Glucagonoma	Weight loss	ORPHA:97280
Pulmonary Alveolar Microlithiasis	Weight loss	ORPHA:60025
Postinfectious Vasculitis	Weight loss	ORPHA:48435
Behçet Disease	Weight loss	ORPHA:117
Dermatomyositis	Weight loss	ORPHA:221
Pearson Syndrome	Malabsorption of Vitamin B12, Small for gestational age	ORPHA:699
Juvenile Polyposis Of Infancy	Cachexia	ORPHA:79076
Liver Disease, Severe Congenital	Failure to thrive, Low levels of vitamin D, Decreased circulating vitamin E concentration	OMIM:619991
Nijmegen Breakage Syndrome	Cachexia	ORPHA:647
Primary Fanconi Renotubular Syndrome	Weight loss	ORPHA:3337
Nocardiosis	Weight loss	ORPHA:31204
Igg4-Related Dacryoadenitis And Sialadenitis	Weight loss	ORPHA:79078
Multiple Endocrine Neoplasia Type 1	Weight loss	ORPHA:652
Cockayne Syndrome	Cachexia	ORPHA:191
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency	Failure to thrive, Weight loss	ORPHA:90794
Hutchinson-Gilford Progeria Syndrome	Severe failure to thrive, Weight loss	ORPHA:740
Sarcoidosis, Susceptibility To, 1	Weight loss	OMIM:181000
Autosomal Dominant Cutis Laxa	Low levels of vitamin D	ORPHA:90348
Marfan Syndrome	Slender build, Cachexia	ORPHA:558
Congenital Erythropoietic Porphyria	Low levels of vitamin D	ORPHA:79277
Autoimmune Lymphoproliferative Syndrome	Abnormal vitamin B12 level	ORPHA:3261
Camurati-Engelmann Disease	Slender build, Cachexia	ORPHA:1328
Kikuchi-Fujimoto Disease	Weight loss	ORPHA:50918
Igg4-Related Kidney Disease	Weight loss	ORPHA:449395
Immunodeficiency 82 With Systemic Inflammation	Weight loss	OMIM:619381
Choreoacanthocytosis	Weight loss	ORPHA:2388
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome	Cachexia	ORPHA:2072
Stickler Syndrome	Slender build, Cachexia	ORPHA:828
Cushing Syndrome Due To Ectopic Acth Secretion	Truncal obesity, Abdominal obesity, Increased body weight, Weight loss	ORPHA:99889
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome	Low levels of vitamin D	ORPHA:438213
Sarcoidosis	Weight loss	ORPHA:797
Chronic Graft Versus Host Disease	Weight loss	ORPHA:99921
Tubulointerstitial Nephritis And Uveitis Syndrome	Weight loss	ORPHA:91500
African Trypanosomiasis	Weight loss	ORPHA:3385
Proteus Syndrome	Cachexia	ORPHA:744
Goodpasture Syndrome	Weight loss	OMIM:233450
Norrie Disease	Failure to thrive, Cachexia	ORPHA:649
Tropical Endomyocardial Fibrosis	Cachexia	ORPHA:75565
Alcohol Dependence		OMIM:103780
Parkinson Disease, Late-Onset		OMIM:168600

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adh1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adh1.

No publications found that use IMPC mice or data for Adh1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Adh1^{tm1e(KOMP)Mbp}	Targeted, non-conditional allele	ES Cells
Adh1^{tm91960(L1L2_Pgk_P)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Adh1^{tm2e(KOMP)Mbp}	Targeted, non-conditional allele	ES Cells
Adh1^{tm2a(KOMP)Mbp}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells
Adh1^{tm1a(KOMP)Mbp}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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