Aspa | aspartoacylase

GeneMGI:87914Synonyms: nur7, aspartoacylase, +3 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Nervous system Vision/eye Hematopoietic system Behavior/neurological

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:16Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased circulating alkaline phosphatase level1 supporting datasetAspatm1b(EUCOMM)WtsihomozygoteEarly adult3.73x10-5 
decreased prepulse inhibition5 supporting datasetsAspatm1b(EUCOMM)WtsihomozygoteEarly adult2.53x10-15 
abnormal cornea morphology1 supporting datasetAspatm1b(EUCOMM)WtsihomozygoteEarly adult2x10-8 
abnormal gait1 supporting datasetAspatm1b(EUCOMM)WtsihomozygoteEarly adult1.06x10-6 
decreased grip strength2 supporting datasetsAspatm1b(EUCOMM)WtsihomozygoteEarly adult1.47x10-5 
abnormal lens morphology1 supporting datasetAspatm1b(EUCOMM)WtsihomozygoteEarly adult5.53x10-5 
increased mean corpuscular volume1 supporting datasetAspatm1b(EUCOMM)WtsihomozygoteEarly adult1.55x10-5 
increased fasting circulating glucose level1 supporting datasetAspatm1b(EUCOMM)WtsihomozygoteEarly adult1.06x10-12 
hyperactivity2 supporting datasetsAspatm1b(EUCOMM)WtsihomozygoteEarly adult4.65x10-8 
decreased startle reflex1 supporting datasetAspatm1b(EUCOMM)WtsihomozygoteEarly adult1.1x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Aspatm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Aspatm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Aspatm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Aspatm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell
Aspatm2a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Aspatm2e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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