Gene Summary

Name:
aminoacylase 1
Synonyms:
1110014J22Rik,  Acy-1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Acy1em1(IMPC)J HOM   Late adult 5.19×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

9 Images

X-ray

XRay Images Whole Body Lateral Orientation

9 Images

X-ray

XRay Images Skull Lateral Orientation

9 Images

X-ray

XRay Images Whole Body Dorso Ventral

9 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

9 Images

Eye Morphology

Images Ophthalmoscopy

7 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

7 Images

Human diseases caused by Acy1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Acy1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Aminoacylase 1 Deficiency
OMIM:609924
Neurological Conditions Associated With Aminoacylase 1 Deficiency
ORPHA:137754

The table below shows human diseases predicted to be associated to Acy1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Aminoacylase 1 Deficiency
OMIM:609924
Neurological Conditions Associated With Aminoacylase 1 Deficiency
ORPHA:137754

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Acy1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Acy1.

No publications found that use IMPC mice or data for Acy1.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Acy1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Acy1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Acy1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Acy1tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Acy1em1(IMPC)J Exon Deletion Mice

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