Genes Phenotypes

Gene: Acvr2b

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Name
activin receptor IIB
MGI ID
MGI:87912
Synonyms
ActRIIB
Viability
Homozygous - Subviable
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (6) Measurements chart (175) All data table (471)
Expression & images (102) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
pale yolk sac Acvr2btm1.1(KOMP)Vlcg HET E12.5 0.00
preweaning lethality, incomplete penetrance Acvr2btm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal eye morphology Acvr2btm1.1(KOMP)Vlcg HET E12.5 0.00
decreased startle reflex Acvr2btm1.1(KOMP)Vlcg HET Early adult 5.53×10-05
pallor Acvr2btm1.1(KOMP)Vlcg HET E12.5 0.00
abnormal embryo size Acvr2btm1.1(KOMP)Vlcg HET E12.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 1 No  (2/584) N/A
Aorta 1 No N/A
Blood 1 No N/A
Bone marrow 1 No N/A
Brain 1 No N/A
Brainstem 1 No N/A
Brown adipose tissue 1 No N/A
Cartilage tissue 1 No N/A
Cecum 1 No  (12/379) N/A
Cerebellum 1 No N/A
Cerebral cortex 1 No N/A
Chest bone 1 No N/A
Colon 1 No  (12/127) N/A
Diaphragm 1 No N/A
Duodenum 1 No  (2/127) N/A
Epididymis 1 No  (18/134)  (1/1)  Section images
Esophagus 1 No  (7/415) N/A
Eye 1 No N/A
Gall bladder 1 No N/A
Gonadal fat pad 1 No N/A
Harderian gland 1 No N/A
Heart 1 No N/A
Hindlimb 1 No N/A
Hippocampus 1 No N/A
Hypothalamus 1 No N/A
Ileum 1 No  (14/127)  (1/1)  Section images
Jejunum 1 No  (6/127) N/A
Kidney 1 No  (18/584) N/A
Large intestine 1 No  (10/584) N/A
Liver 1 No N/A
Lower urinary tract 1 No N/A
Lung 1 No N/A
Lymph node 1 No N/A
Mammary gland 1 No N/A
Mesenteric adipose tissue 1 No N/A
Mesenteric lymph node 1 No N/A
Midbrain 1 No N/A
Olfactory lobe 1 No N/A
Ovary 1 No  (1/584) N/A
Oviduct 1 No N/A
Pancreas 1 No  (5/584) N/A
Parathyroid gland 1 No N/A
Parotid gland 1 No N/A
Penis 1 No N/A
Peripheral nervous system 1 No N/A
Peyer's patch 1 No N/A
Pituitary gland 1 No N/A
Prostate gland 1 No  (12/584)  (1/1)  Section images
Quadriceps 1 No N/A
Sciatic nerve 1 No N/A
Skeletal muscle 1 No N/A
Skin 1 No N/A
Small intestine 1 No  (9/584) N/A
Spinal cord 1 No N/A
Spleen 1 No  (2/584) N/A
Stomach 1 No  (12/584) N/A
Stomach pyloric region 1 No N/A
Striatum 1 No N/A
Sublingual gland 1 No N/A
Submandibular gland 1 No  (2/132) N/A
Testis 1 No  (2/584) N/A
Thymus 1 No N/A
Thyroid gland 1 No  (15/584) N/A
Tongue 1 No  (5/127) N/A
Trachea 1 No N/A
Trigeminal V nerve 1 No N/A
Urinary bladder 1 No N/A
Uterus 1 No N/A
Vagina 1 No N/A
Vas deferens 1 No  (15/388)  (1/1)  Section images
Vascular system 1 No N/A
Vesicular gland 1 No N/A
White adipose tissue 1 No N/A
LacZ Wholemount Images
LacZ Section Images
Unassigned Top Level MA (1)
digestive system (1)
Ileum expression
MA:0000339
exocrine system (1)
Prostate gland expression
MA:0000404
postnatal mouse (4)
Epididymis expression
MA:0000397
reproductive system (3)
Epididymis expression
MA:0000397
trunk (4)
Epididymis expression
MA:0000397
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/61) N/A
Brain 2  (6/504)  (2/2) N/A
Central nervous system ganglion 2  (1/70) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/2) N/A
Eye 2  (1/504)  (2/2) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504)  (2/2) N/A
Forelimb 2  (1/504) N/A
Gut 2  (1/56)  (2/2) N/A
Hand 2  (1/503) N/A
Head 2  (5/504) N/A
Heart 2  (1/504)  (2/2) N/A
Hindbrain 2  (6/504)  (2/2) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504)  (2/2) N/A
Nose 2  (1/70) N/A
Oral cavity 2  (1/504) N/A
Skeleton 2  (1/70) N/A
Skin 2  (1/504) N/A
Spinal cord 2  (1/69) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A
Trachea 2  (1/56) N/A
Urinary system 2  (1/56)  (2/2) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
70 Images
Adult LacZ: LacZ Images Section
5 Images
X-ray: XRay Images Whole Body Dorso Ventral
40 Images
X-ray: XRay Images Whole Body Lateral Orientation
20 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Acvr2btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Acvr2btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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