Acvr2b - activin receptor IIB | International Mouse Phenotyping Consortium

Phenotype	Allele	Zyg	Life Stage	P Value
decreased startle reflex	Acvr2b^{tm1.1(KOMP)Vlcg}	HET	postnatal	5.48×10^-05
pallor	Acvr2b^{tm1.1(KOMP)Vlcg}	HET	embryonic day 12.5	0.00
abnormal eye morphology	Acvr2b^{tm1.1(KOMP)Vlcg}	HET	embryonic day 12.5	0.00
abnormal embryo size	Acvr2b^{tm1.1(KOMP)Vlcg}	HET	embryonic day 12.5	0.00
pale yolk sac	Acvr2b^{tm1.1(KOMP)Vlcg}	HET	embryonic day 12.5	0.00
preweaning lethality, incomplete penetrance	Acvr2b^{tm1.1(KOMP)Vlcg}	HOM	n/a	0.00

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr	Images
Adrenal gland	1	No	(2/584)		N/A
Aorta	1	No			N/A
Blood	1	No			N/A
Bone marrow	1	No			N/A
Brain	1	No			N/A
Brainstem	1	No			N/A
Brown adipose tissue	1	No			N/A
Cartilage tissue	1	No			N/A
Cecum	1	No	(12/383)		N/A
Cerebellum	1	No			N/A
Cerebral cortex	1	No			N/A
Chest bone	1	No			N/A
Colon	1	No	(12/127)		N/A
Diaphragm	1	No			N/A
Duodenum	1	No	(2/127)		N/A
Epididymis	1	No	(18/134)	(1/1)	N/A
Esophagus	1	No	(7/415)		N/A
Eye	1	No			N/A
Gall bladder	1	No			N/A
Gonadal fat pad	1	No			N/A
Harderian gland	1	No			N/A
Heart	1	No			N/A
Hindlimb	1	No			N/A
Hippocampus	1	No			N/A
Hypothalamus	1	No			N/A
Ileum	1	No	(14/127)	(1/1)	N/A
Jejunum	1	No	(6/127)		N/A
Kidney	1	No	(18/584)		N/A
Large intestine	1	No	(10/584)		N/A
Liver	1	No			N/A
Lower urinary tract	1	No			N/A
Lung	1	No			N/A
Lymph node	1	No			N/A
Mammary gland	1	No			N/A
Mesenteric adipose tissue	1	No			N/A
Mesenteric lymph node	1	No			N/A
Midbrain	1	No			N/A
Olfactory lobe	1	No			N/A
Ovary	1	No	(1/584)		N/A
Oviduct	1	No			N/A
Pancreas	1	No	(5/584)		N/A
Parathyroid gland	1	No			N/A
Parotid gland	1	No			N/A
Penis	1	No			N/A
Peripheral nervous system	1	No			N/A
Peyer's patch	1	No			N/A
Pituitary gland	1	No			N/A
Prostate gland	1	No	(12/584)	(1/1)	N/A
Quadriceps	1	No			N/A
Sciatic nerve	1	No			N/A
Skeletal muscle	1	No			N/A
Skin	1	No			N/A
Small intestine	1	No	(9/584)		N/A
Spinal cord	1	No			N/A
Spleen	1	No	(2/584)		N/A
Stomach	1	No	(12/584)		N/A
Stomach pyloric region	1	No			N/A
Striatum	1	No			N/A
Sublingual gland	1	No			N/A
Submandibular gland	1	No	(2/132)		N/A
Testis	1	No	(2/584)		N/A
Thymus	1	No			N/A
Thyroid gland	1	No	(15/584)		N/A
Tongue	1	No	(5/127)		N/A
Trachea	1	No			N/A
Trigeminal V nerve	1	No			N/A
Urinary bladder	1	No			N/A
Uterus	1	No			N/A
Vagina	1	No			N/A
Vas deferens	1	No	(15/388)	(1/1)	N/A
Vascular system	1	No			N/A
Vesicular gland	1	No			N/A
White adipose tissue	1	No			N/A

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	WT Expr	Mutant Expr	Images
Axial skeleton	2	(1/51)		N/A
Brain	2	(6/485)	(2/2)	N/A
Central nervous system ganglion	2	(1/51)		N/A
Ear	2	(1/485)		N/A
Embryo	2	(1/485)	(2/2)	N/A
Eye	2	(1/485)	(2/2)	N/A
Foot	2	(1/485)		N/A
Forebrain	2	(1/485)	(2/2)	N/A
Forelimb	2	(1/485)		N/A
Gut	2	(1/50)	(2/2)	N/A
Hand	2	(1/485)		N/A
Head	2	(5/485)		N/A
Heart	2	(1/485)	(2/2)	N/A
Hindbrain	2	(6/485)	(2/2)	N/A
Hindlimb	2	(1/485)		N/A
Liver	2	(1/485)		N/A
Lung	2	(1/485)		N/A
Mandibular process	2	(1/485)		N/A
Maxillary process	2	(1/485)		N/A
Midbrain	2	(1/485)	(2/2)	N/A
Nose	2	(1/51)		N/A
Oral cavity	2	(1/485)		N/A
Skeleton	2	(1/51)		N/A
Skin	2	(1/485)		N/A
Spinal cord	2	(1/50)		N/A
Tail	2	(1/485)		N/A
Tail somite	2	(1/485)		N/A
Trachea	2	(1/50)		N/A
Urinary system	2	(1/50)	(2/2)	N/A

MGI Allele	Allele Type	Availability
Acvr2b^{tm1(KOMP)Vlcg}	Reporter-tagged deletion allele (with selection cassette)	Mice, Targeting vectors, ES Cells
Acvr2b^{tm1.1(KOMP)Vlcg}	Reporter-tagged deletion allele (post Cre, with no selection cassette)	Mice, Tissue

MGI Allele

Allele Type

Availability

Acvr2b^{tm1(KOMP)Vlcg}

Reporter-tagged deletion allele (with selection cassette)

Mice, Targeting vectors, ES Cells

Acvr2b^{tm1.1(KOMP)Vlcg}

Reporter-tagged deletion allele (post Cre, with no selection cassette)

Mice, Tissue

Gene: Acvr2b