Genes Phenotypes

Gene: Acvr2b

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Name
activin receptor IIB
MGI ID
MGI:87912
Synonyms
ActRIIB
Viability
Homozygous - Subviable
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (6) Measurements chart (175) All data table (786)
Expression & images (102) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Acvr2btm1.1(KOMP)Vlcg HET embryonic day 12.5 0.00
preweaning lethality, incomplete penetrance Acvr2btm1.1(KOMP)Vlcg HOM n/a 0.00
decreased startle reflex Acvr2btm1.1(KOMP)Vlcg HET postnatal 5.48×10-05
pale yolk sac Acvr2btm1.1(KOMP)Vlcg HET embryonic day 12.5 0.00
abnormal embryo size Acvr2btm1.1(KOMP)Vlcg HET embryonic day 12.5 0.00
pallor Acvr2btm1.1(KOMP)Vlcg HET embryonic day 12.5 0.00

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 1 No  (2/584) N/A
Aorta 1 No N/A
Blood 1 No N/A
Bone marrow 1 No N/A
Brain 1 No N/A
Brainstem 1 No N/A
Brown adipose tissue 1 No N/A
Cartilage tissue 1 No N/A
Cecum 1 No  (12/383) N/A
Cerebellum 1 No N/A
Cerebral cortex 1 No N/A
Chest bone 1 No N/A
Colon 1 No  (12/127) N/A
Diaphragm 1 No N/A
Duodenum 1 No  (2/127) N/A
Epididymis 1 No  (18/134)  (1/1) N/A
Esophagus 1 No  (7/415) N/A
Eye 1 No N/A
Gall bladder 1 No N/A
Gonadal fat pad 1 No N/A
Harderian gland 1 No N/A
Heart 1 No N/A
Hindlimb 1 No N/A
Hippocampus 1 No N/A
Hypothalamus 1 No N/A
Ileum 1 No  (14/127)  (1/1) N/A
Jejunum 1 No  (6/127) N/A
Kidney 1 No  (18/584) N/A
Large intestine 1 No  (10/584) N/A
Liver 1 No N/A
Lower urinary tract 1 No N/A
Lung 1 No N/A
Lymph node 1 No N/A
Mammary gland 1 No N/A
Mesenteric adipose tissue 1 No N/A
Mesenteric lymph node 1 No N/A
Midbrain 1 No N/A
Olfactory lobe 1 No N/A
Ovary 1 No  (1/584) N/A
Oviduct 1 No N/A
Pancreas 1 No  (5/584) N/A
Parathyroid gland 1 No N/A
Parotid gland 1 No N/A
Penis 1 No N/A
Peripheral nervous system 1 No N/A
Peyer's patch 1 No N/A
Pituitary gland 1 No N/A
Prostate gland 1 No  (12/584)  (1/1) N/A
Quadriceps 1 No N/A
Sciatic nerve 1 No N/A
Skeletal muscle 1 No N/A
Skin 1 No N/A
Small intestine 1 No  (9/584) N/A
Spinal cord 1 No N/A
Spleen 1 No  (2/584) N/A
Stomach 1 No  (12/584) N/A
Stomach pyloric region 1 No N/A
Striatum 1 No N/A
Sublingual gland 1 No N/A
Submandibular gland 1 No  (2/132) N/A
Testis 1 No  (2/584) N/A
Thymus 1 No N/A
Thyroid gland 1 No  (15/584) N/A
Tongue 1 No  (5/127) N/A
Trachea 1 No N/A
Trigeminal V nerve 1 No N/A
Urinary bladder 1 No N/A
Uterus 1 No N/A
Vagina 1 No N/A
Vas deferens 1 No  (15/388)  (1/1) N/A
Vascular system 1 No N/A
Vesicular gland 1 No N/A
White adipose tissue 1 No N/A
LacZ Wholemount Images
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51) N/A
Brain 2  (6/485)  (2/2) N/A
Central nervous system ganglion 2  (1/51) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (2/2) N/A
Eye 2  (1/485)  (2/2) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485)  (2/2) N/A
Forelimb 2  (1/485) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Heart 2  (1/485)  (2/2) N/A
Hindbrain 2  (6/485)  (2/2) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485)  (2/2) N/A
Nose 2  (1/51) N/A
Oral cavity 2  (1/485) N/A
Skeleton 2  (1/51) N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A
Trachea 2  (1/50) N/A
Urinary system 2  (1/50)  (2/2) N/A

 Associated Images

X-ray: XRay Images Dorso Ventral
40 Images
X-ray: XRay Images Lateral Orientation
20 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Acvr2btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Acvr2btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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