Chrnb2 | cholinergic receptor nicotinic beta 2 subunit

GeneMGI:87891Synonyms: Acrb2, C030030P04Rik, +2 more

Physiological systems

19 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Adipose tissue Growth/size/body region Vision/eye Cardiovascular system Mortality/aging

12 No significant impact

5 Not tested

Gene metrics:6Significant phenotypes
2Associated diseases
Expression examined in:46Adult tissues
0Embryo tissues

Phenotypes

persistence of hyaloid vascular system1 supporting datasetChrnb2tm1b(EUCOMM)HmguheterozygoteEarly adult4.18x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetChrnb2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
enlarged heart1 supporting datasetChrnb2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased total body fat amount1 supporting datasetChrnb2tm1b(EUCOMM)HmguhomozygoteEarly adult1.01x10-5 
abnormal epididymis morphology1 supporting datasetChrnb2tm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating aspartate transaminase level1 supporting datasetChrnb2tm1b(EUCOMM)HmguheterozygoteEarly adult7.78x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Chrnb2tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Chrnb2tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
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