The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy
Images
Zygosity
Mutant Expr
Heart atrium
N/A
heterozygote
100% (3 of 3)
Axial skeleton
N/A
heterozygote
100% (3 of 3)
Brain
N/A
heterozygote
100% (3 of 3)
Central nervous system ganglion
N/A
heterozygote
100% (3 of 3)
Cranium
N/A
heterozygote
100% (3 of 3)
Dorsal root ganglion
N/A
heterozygote
100% (3 of 3)
Ear
N/A
heterozygote
100% (3 of 3)
Embryo
N/A
heterozygote
100% (3 of 3)
Outer ear
N/A
heterozygote
100% (3 of 3)
Eye
N/A
heterozygote
100% (3 of 3)
Femur pre-cartilage condensation
N/A
heterozygote
100% (3 of 3)
Footplate
N/A
heterozygote
100% (3 of 3)
Forearm
N/A
heterozygote
100% (3 of 3)
Forebrain
N/A
heterozygote
100% (3 of 3)
Forelimb
N/A
heterozygote
100% (3 of 3)
Fronto-nasal process
N/A
heterozygote
100% (3 of 3)
Gut
N/A
heterozygote
100% (3 of 3)
Handplate
N/A
heterozygote
100% (3 of 3)
Head mesenchyme
N/A
heterozygote
100% (3 of 3)
Head
N/A
heterozygote
100% (3 of 3)
Heart ventricle
N/A
heterozygote
100% (3 of 3)
Heart
N/A
heterozygote
100% (3 of 3)
Hindbrain
N/A
heterozygote
100% (3 of 3)
Hindlimb
N/A
heterozygote
100% (3 of 3)
Humerus pre-cartilage condensation
N/A
heterozygote
100% (3 of 3)
Inner ear
N/A
heterozygote
100% (3 of 3)
Intestine
N/A
heterozygote
100% (3 of 3)
Liver
N/A
heterozygote
100% (3 of 3)
Lower leg
N/A
heterozygote
100% (3 of 3)
Lung
N/A
heterozygote
100% (3 of 3)
Mandibular process
N/A
heterozygote
100% (3 of 3)
Maxillary process
N/A
heterozygote
100% (3 of 3)
Mesonephros of female
N/A
heterozygote
66.67% (2 of 3)
Mesonephros of male
N/A
heterozygote
100% (3 of 3)
Metanephros
N/A
heterozygote
100% (3 of 3)
Midbrain
N/A
heterozygote
100% (3 of 3)
Nasal septum
N/A
heterozygote
100% (3 of 3)
Nose
N/A
heterozygote
100% (3 of 3)
Notochord
N/A
heterozygote
100% (3 of 3)
Oral cavity
N/A
heterozygote
100% (3 of 3)
Outflow tract
N/A
heterozygote
100% (3 of 3)
Pancreas
N/A
heterozygote
100% (3 of 3)
N/A
heterozygote
100% (3 of 3)
Pharynx
N/A
heterozygote
100% (3 of 3)
Radius-ulna pre-cartilage condensation
N/A
heterozygote
100% (3 of 3)
Rib pre-cartilage condensation
N/A
heterozygote
100% (3 of 3)
Skeleton
N/A
heterozygote
100% (3 of 3)
Skin
N/A
heterozygote
100% (3 of 3)
Spinal cord
N/A
heterozygote
100% (3 of 3)
Stomach
N/A
heterozygote
100% (3 of 3)
Tail somite
N/A
heterozygote
100% (3 of 3)
Tail
N/A
heterozygote
100% (3 of 3)
Thoracic vertebral cartilage condensation
N/A
heterozygote
100% (3 of 3)
Tongue
N/A
heterozygote
100% (3 of 3)
Trachea
N/A
heterozygote
100% (3 of 3)
Trunk mesenchyme
N/A
heterozygote
100% (3 of 3)
Umbilical artery embryonic part
N/A
heterozygote
100% (3 of 3)
Umbilical vein embryonic part
N/A
heterozygote
100% (3 of 3)
Upper arm
N/A
heterozygote
100% (3 of 3)
Upper leg
N/A
heterozygote
100% (3 of 3)
Urinary system
N/A
heterozygote
100% (3 of 3)
Vibrissa
N/A
heterozygote
100% (3 of 3)
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy
Background staining in controls (WT)
adrenal gland
0.67% (4 of 598)
aorta
0.17% (1 of 598)
bone
0.0%
brain
0.84% (5 of 598)
brainstem
0.33% (2 of 598)
brown adipose tissue
0.0%
cartilage tissue
0.17% (1 of 598)
cecum
5.73% (22 of 384)
cerebellum
0.5% (3 of 598)
cerebral cortex
0.33% (2 of 598)
esophagus
1.66% (7 of 422)
eye
0.0%
gall bladder
0.0%
heart
0.33% (2 of 598)
hippocampus
0.5% (3 of 598)
hypothalamus
0.33% (2 of 598)
kidney
4.52% (27 of 598)
large intestine
5.35% (32 of 598)
liver
0.0%
lower urinary tract
0.17% (1 of 598)
lung
0.33% (2 of 598)
lymph node
0.17% (1 of 598)
mammary gland
0.0%
olfactory lobe
0.33% (2 of 598)
oral epithelium
0.0%
ovary
0.17% (1 of 598)
oviduct
0.0%
pancreas
0.84% (5 of 598)
parathyroid gland
0.17% (1 of 576)
peripheral nervous system
0.33% (2 of 598)
peyers patch
0.0%
pituitary gland
0.17% (1 of 598)
prostate gland
2.17% (13 of 598)
skeletal muscle
0.0%
skin
0.17% (1 of 598)
small intestine
5.35% (32 of 598)
spinal cord
0.5% (3 of 598)
spleen
0.5% (3 of 598)
stomach
3.68% (22 of 598)
striatum
0.5% (3 of 598)
testis
1% (6 of 598)
thymus
0.17% (1 of 598)
thyroid gland
3.01% (18 of 598)
trachea
0.5% (3 of 598)
trigeminal v nerve
0.0%
uterus
0.33% (2 of 598)
vas deferens
4.56% (18 of 395)
vascular system
0.0%
white adipose tissue
0.0%
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy
Background staining in controls(WT)
atrium
1.75% (1 of 57)
axial skeleton
0.0%
brain
1.36% (6 of 440)
central nervous system ganglion
0.0%
cranium
1.72% (1 of 58)
dorsal root ganglion
1.75% (1 of 57)
ear
0.0%
embryo
0.22% (1 of 458)
external ear
1.45% (1 of 69)
eye
0.22% (1 of 457)
femur pre-cartilage condensation
2.04% (1 of 49)
footplate
0.21% (1 of 466)
forearm
0.37% (1 of 268)
forebrain
0.22% (1 of 455)
forelimb
0.22% (1 of 452)
fronto-nasal process
1.82% (1 of 55)
gut
1.85% (1 of 54)
handplate
0.22% (1 of 460)
head
0.87% (4 of 461)
head mesenchyme
1.85% (1 of 54)
heart
0.22% (1 of 455)
heart ventricle
1.85% (1 of 54)
hindbrain
1.08% (5 of 463)
hindlimb
0.0%
humerus pre-cartilage condensation
1.79% (1 of 56)
inner ear
1.67% (1 of 60)
intestine
0.0%
liver
0.22% (1 of 454)
lower leg
0.37% (1 of 270)
lung
0.22% (1 of 453)
mandibular process
0.0%
maxillary process
0.22% (1 of 445)
mesonephros of female
0.0%
mesonephros of male
1.92% (1 of 52)
metanephros
1.96% (1 of 51)
midbrain
0.22% (1 of 458)
nasal septum
1.92% (1 of 52)
nose
1.45% (1 of 69)
notochord
1.85% (1 of 54)
oral cavity
0.22% (1 of 451)
outflow tract
1.85% (1 of 54)
pancreas
2.13% (1 of 47)
pericardium
2.08% (1 of 48)
pharynx
1.89% (1 of 53)
radius-ulna pre cartilage condensation
1.92% (1 of 52)
rib pre-cartilage condensation
2.17% (1 of 46)
skeleton
1.43% (1 of 70)
skin
0.22% (1 of 458)
spinal cord
1.59% (1 of 63)
stomach
2% (1 of 50)
tail
0.22% (1 of 465)
tail somite group
0.22% (1 of 455)
thoracic vertebral cartilage condensation
2.08% (1 of 48)
tongue
2.04% (1 of 49)
trachea
0.0%
trunk mesenchyme
1.89% (1 of 53)
umbilical artery embryonic part
1.92% (1 of 52)
umbilical vein embryonic part
1.92% (1 of 52)
upper arm
0.37% (1 of 273)
upper leg
0.0%
urinary system
1.96% (1 of 51)
vibrissa
1.52% (1 of 66)
Associated Images
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
X-ray
XRay Images Forepaw
15 Images
X-ray
XRay Images Skull Dorso Ventral Orientation
15 Images
X-ray
XRay Images Whole Body Dorso Ventral
15 Images
Embryo LacZ
LacZ images wholemount
4 Images
Eye Morphology
VIP of left eye
18 Images
Eye Morphology
VIP of right fundus
18 Images
X-ray
XRay Images Whole Body Lateral Orientation
15 Images
Eye Morphology
VIP of left fundus
18 Images
Adult LacZ
LacZ Images Wholemount
12 Images
Eye Morphology
VIP of right eye
18 Images
X-ray
XRay Images Skull Lateral Orientation
15 Images
MicroCT E18.5
Embryo reconstruction
8 Images
Human diseases caused by Acat2 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Acat2
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Acat2.
No publications found that use IMPC mice or data for Acat2.
Order Mouse and ES Cells
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
