The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Legacy Phenotype Associated Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Cpgi81 by phenotypic similarity.
|Cramps, Familial Adolescent||
||Elevated circulating creatine kinase concentration||OMIM:218050|
|Muscle Cramps, Familial||
||Elevated circulating creatine kinase concentration||OMIM:158400|
|Hemochromatosis, Type 5||
||Increased circulating ferritin concentration||OMIM:615517|
|Plasma Fibronectin Deficiency||
||Reduced circulating fibronectin level||OMIM:614101|
||Abnormality of circulating enzyme level, Abnormal circulating carbohydrate concentration||ORPHA:2843|
|Vacuolar Myopathy With Sarcoplasmic Reticulum Protein Aggregates||
||Elevated circulating creatine kinase concentration||ORPHA:88635|
|Erythrocyte Lactate Transporter Defect||
||Elevated circulating creatine kinase concentration||OMIM:245340|
|Alpha-Fetoprotein, Hereditary Persistence Of||
||Decreased levels of alpha-fetoprotein||OMIM:615969|
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|MGI Allele||Allele Type||Produced|
|Cpgi81tm1(NCC)WCS||Truncation cassette with conditional potential (selection cassette)||Mice, Targeting vectors, ES Cells|
|Cpgi81tm1.1(NCC)WCS||Truncated CpG island (post-Cre)||Mice|