Gene: Mndal MGI:3780953
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal embryo size | Mndalem1(IMPC)Bay | HET | E12.5 | 0.00 | ||
preweaning lethality, complete penetrance | Mndalem1(IMPC)Bay | HOM | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Mndalem1(IMPC)Wtsi | HOM | Early adult | 7.54×10-06 | ||
abnormal embryo size | Mndalem1(IMPC)Bay | HET | E9.5 | 0.00 | ||
abnormal gait | Mndalem1(IMPC)Wtsi | HET | Early adult | 1.44×10-05 |
Human diseases caused by Mndal mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Mndal by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Psychogenic Movement Disorders | Gait disturbance | ORPHA:71519 | |
Benign Hereditary Chorea | Gait disturbance | ORPHA:1429 | |
Vertigo, Benign Recurrent | Gait imbalance | OMIM:193007 | |
Ataxia-Oculomotor Apraxia Type 1 | Ataxia, Gait disturbance | ORPHA:1168 | |
Early-Onset Generalized Limb-Onset Dystonia | Gait disturbance | ORPHA:256 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Mndalem1(IMPC)Wtsi | Exon Deletion | Mice |
Mndalem1(IMPC)Bay | Exon Deletion | Mice |
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