Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
vomeronasal 2, receptor 53
Synonyms:
EG637908

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Vmn2r53 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Vmn2r53 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autism, Susceptibility To, 20
Impaired social interactions OMIM:618830
Asperger Syndrome, Susceptibility To, 1
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608638
Asperger Syndrome, X-Linked, Susceptibility To, 2
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:300497
Asperger Syndrome, X-Linked, Susceptibility To, 1
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:300494
Asperger Syndrome, Susceptibility To, 2
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608631
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Autism, Susceptibility To, X-Linked 1
Lack of peer relationships, Abnormal nonverbal communicative behavior OMIM:300425
Autism
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:209850
Autism, Susceptibility To, 8
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:607373
Autism, Susceptibility To, X-Linked 3
Lack of peer relationships, Abnormal nonverbal communicative behavior OMIM:300496
Chromosome 15Q11-Q13 Duplication Syndrome
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608636
Intellectual Developmental Disorder, Autosomal Recessive 66
Shyness, Aggressive behavior OMIM:618221
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
Autism, Susceptibility To, X-Linked 2
Lack of peer relationships, Abnormal nonverbal communicative behavior OMIM:300495
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Impaired social interactions, No social interaction, Aggressive behavior ORPHA:329249
Autism, Susceptibility To, 3
Impaired ability to form peer relationships, Abnormal nonverbal communicative behavior OMIM:608049
Early-Onset Schizophrenia
Abnormal emotion/affect behavior, Anxiety, No social interaction, Lack of peer relationships, Sui... ORPHA:96369
11Q22.2Q22.3 Microdeletion Syndrome
Anxiety, Poor eye contact, Abnormal social behavior ORPHA:444002
Female Restricted Epilepsy With Intellectual Disability
Anxiety, Aggressive behavior, Abnormal social behavior ORPHA:101039
Hsd10 Disease
Abnormal social behavior ORPHA:391417
Dopa-Responsive Dystonia
Agoraphobia, Abnormal social behavior, Anxiety, Panic attack, Emotional lability, Irritability ORPHA:255
Lamb-Shaffer Syndrome
Abnormal social behavior ORPHA:530983
Childhood Absence Epilepsy
Anxiety, Abnormal social behavior ORPHA:64280
48,Xxxy Syndrome
Abnormal aggressive, impulsive or violent behavior, Anxiety, Irritability, Abnormal social behavior ORPHA:96263
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior ORPHA:1020
Metachromatic Leukodystrophy, Late Infantile Form
Emotional lability, Abnormal social behavior ORPHA:309256
Metachromatic Leukodystrophy, Juvenile Form
Emotional lability, Abnormal social behavior ORPHA:309263
Prader-Willi Syndrome Due To Translocation
Happy demeanor, Head-banging, Abnormal social behavior, Anxiety, Impaired social interactions, Sk... ORPHA:177907
Metachromatic Leukodystrophy, Adult Form
Emotional lability, Abnormal social behavior ORPHA:309271
Fg Syndrome Type 1
Abnormal social behavior ORPHA:93932
Dihydropyrimidine Dehydrogenase Deficiency
Abnormal aggressive, impulsive or violent behavior, Irritability, Abnormal social behavior ORPHA:1675
Mend Syndrome
Aggressive behavior, Abnormal social behavior ORPHA:401973
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Aggressive behavior, Abnormal social behavior ORPHA:314647
Tuberous Sclerosis Complex
Anxiety, Self-injurious behavior, Aggressive behavior, Abnormal social behavior ORPHA:805
Koolen-De Vries Syndrome Due To A Point Mutation
Overfriendliness, Anxiety, Abnormal social behavior ORPHA:363965
17Q21.31 Microdeletion Syndrome
Overfriendliness, Anxiety, Abnormal social behavior ORPHA:363958
Niemann-Pick Disease Type C
Apathy, Low frustration tolerance, Aggressive behavior, Abnormal social behavior ORPHA:646
Williams Syndrome
Overfriendliness, Anxiety, Abnormal social behavior ORPHA:904

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Vmn2r53

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Vmn2r53.

No publications found that use IMPC mice or data for Vmn2r53.

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