The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Angptl8 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Angptl8.
There are 4 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance.||Journal of lipid research (April 2017)||Angptl8tm1(KOMP)Vlcg||PMC5454515|
|Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion.||Journal of lipid research (May 2015)||Angptl8tm1(KOMP)Vlcg||PMC4479334|
|ANGPTL8/betatrophin does not control pancreatic beta cell expansion.||Cell (October 2014)||Angptl8tm1(KOMP)Vlcg||PMC4243040|
|Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis.||Proceedings of the National Academy of Sciences of the United States of America (September 2013)||Angptl8tm1(KOMP)Vlcg||PMC3791734|
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|MGI Allele||Allele Type||Produced|
|Angptl8tm1(KOMP)Wtsi||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|
|Angptl8tm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||ES Cells|