Gene Summary

angiopoietin-like 8
Gm6484,  Lipasin,  Rifl

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Angptl8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Angptl8 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Hypertriglyceridemia 2
Hypertriglyceridemia, Hypercholesterolemia OMIM:619324
Glycogen Storage Disease Vi
Hyperlipidemia, Hypertriglyceridemia, Elevated hepatic transaminase, Hypercholesterolemia, Postna... OMIM:232700
Cholesterol-Ester Transfer Protein Deficiency
Hyperlipidemia, Hyperlipoproteinemia, Increased HDL cholesterol concentration, Hypotriglyceridemi... ORPHA:79506
Citrullinemia, Type Ii, Neonatal-Onset
Failure to thrive, Hyperbilirubinemia, Decreased HDL cholesterol concentration, Hypermethioninemi... OMIM:605814
Obesity Due To Melanocortin 4 Receptor Deficiency
Hypertriglyceridemia, Childhood-onset truncal obesity, Obesity, Increased adipose tissue ORPHA:71529
Sitosterolemia 2
Elevated circulating sitosterol concentration, Hypercholesterolemia OMIM:618666
Fish-Eye Disease
Hypertriglyceridemia, Decreased HDL cholesterol concentration, Increased VLDL cholesterol concent... OMIM:136120
Lipase Deficiency, Combined
Hypertriglyceridemia, Lipodystrophy OMIM:246650
Lipodystrophy, Familial Partial, Type 6
Abdominal obesity, Hyperlipidemia, Abnormal circulating lipid concentration, Elevated circulating... OMIM:615980
Lipodystrophy, Partial, Acquired, Susceptibility To
Loss of truncal subcutaneous adipose tissue, Abnormal circulating lipid concentration, Progressiv... OMIM:608709
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Elevated circulating alkaline phosphatase concentration, Hypermethioninemia, Abnormal circulating... ORPHA:247598
Lipodystrophy Due To Peptidic Growth Factors Deficiency
Reduced subcutaneous adipose tissue, Hyperlipoproteinemia, Lipoatrophy, Flexion contracture, Abno... ORPHA:1979
Pancreatic Lipase Deficiency
Hypolipidemia, Steatorrhea OMIM:614338
Parenteral Nutrition-Associated Cholestasis
Hyperlipidemia, Elevated circulating alkaline phosphatase concentration, Abnormal circulating fat... ORPHA:567983
Stiff Skin Syndrome
Short stature, Lipoatrophy, Abnormal circulating lipid concentration ORPHA:2833
Idiopathic Steroid-Resistant Nephrotic Syndrome
Abnormal circulating lipid concentration, Hypertriglyceridemia, Hypoalbuminemia, Hypercholesterol... ORPHA:567548
Subaortic Stenosis-Short Stature Syndrome
Obesity, Short stature, Inguinal hernia, Abnormal circulating lipid concentration ORPHA:3191
Acquired Generalized Lipodystrophy
Hypertriglyceridemia, Generalized lipodystrophy, Abnormal circulating lipid concentration, Pannic... ORPHA:79086
Apolipoprotein A-I Deficiency
Abnormal circulating lipid concentration, Decreased HDL cholesterol concentration, Xanthelasma ORPHA:425
Kennedy Disease
Abnormal circulating lipid concentration ORPHA:481
Griscelli Syndrome
Hepatitis, Short stature, Jaundice, Abnormal circulating lipid concentration ORPHA:381
Adult-Onset Still Disease
Elevated hepatic transaminase, Hepatitis, Elevated circulating C-reactive protein concentration, ... ORPHA:829
Overlap Myositis
Elevated hepatic transaminase, Elevated circulating creatine kinase concentration, Abnormality of... ORPHA:206572
Short Stature, Microcephaly, And Endocrine Dysfunction
Disproportionate short-limb short stature, Inguinal hernia, Abnormal circulating lipid concentrat... OMIM:616541
Chronic Visceral Acid Sphingomyelinase Deficiency
Decreased liver function, Hyperlipidemia, Increased LDL cholesterol concentration, Abnormal circu... ORPHA:77293
Primary Biliary Cholangitis
Elevated circulating alkaline phosphatase concentration, Hepatic failure, Abnormal circulating li... ORPHA:186
Insulin-Resistance Syndrome Type B
Decreased body weight, Abnormal circulating fatty-acid concentration, Abnormal circulating lipid ... ORPHA:2298


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Angptl8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Angptl8.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance. Journal of lipid research (April 2017) Angptl8tm1(KOMP)Vlcg PMC5454515
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. Journal of lipid research (May 2015) Angptl8tm1(KOMP)Vlcg PMC4479334
ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell (October 2014) Angptl8tm1(KOMP)Vlcg PMC4243040
Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America (September 2013) Angptl8tm1(KOMP)Vlcg PMC3791734

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MGI Allele Allele Type Produced
Angptl8tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Angptl8em1(IMPC)Bay Intra-exon deletion Mice
Angptl8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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