Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Ano3 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Dystonia 24 | OMIM:615034 | ||
Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement | ORPHA:420485 |
The table below shows human diseases predicted to be associated to Ano3 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Cramps, Familial Adolescent | Elevated circulating creatine kinase concentration | OMIM:218050 | |
Muscle Cramps, Familial | Elevated circulating creatine kinase concentration | OMIM:158400 | |
Pentosuria | Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level | ORPHA:2843 | |
Isolated Asymptomatic Elevation Of Creatine Phosphokinase | Elevated circulating creatine kinase concentration, Elevated creatine kinase after exercise | ORPHA:206599 | |
Dystonia 24 | OMIM:615034 | ||
Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement | ORPHA:420485 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ano3.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. | Transgenic research (November 2016) | Ano3em2(IMPC)Mbp | PMC5350237 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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MGI Allele | Allele Type | Produced |
---|---|---|
Ano3em2(IMPC)Mbp | Indel | Mice, Tissue |
Ano3tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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