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Gene: Ano3 MGI:3613666

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Gene Summary

Name:
anoctamin 3
Synonyms:
Tmem16c,  B230324K02Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating alanine transaminase level Ano3em2(IMPC)Mbp HOM Early adult 6.93×10-05
preweaning lethality, incomplete penetrance Ano3em2(IMPC)Mbp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Ano3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ano3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Dystonia 24
OMIM:615034
Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement
ORPHA:420485

The table below shows human diseases predicted to be associated to Ano3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cramps, Familial Adolescent
Elevated circulating creatine kinase concentration OMIM:218050
Muscle Cramps, Familial
Elevated circulating creatine kinase concentration OMIM:158400
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level ORPHA:2843
Isolated Asymptomatic Elevation Of Creatine Phosphokinase
Elevated circulating creatine kinase concentration, Elevated creatine kinase after exercise ORPHA:206599
Dystonia 24
OMIM:615034
Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement
ORPHA:420485

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ano3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ano3.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic research (November 2016) Ano3em2(IMPC)Mbp PMC5350237

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MGI Allele Allele Type Produced
Ano3em2(IMPC)Mbp Indel Mice, Tissue
Ano3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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