Gene: Rgs22 MGI:3613651

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Gene Summary

Name:
regulator of G-protein signalling 22
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
female infertility Rgs22tm1b(KOMP)Wtsi HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Brain  Section images heterozygote 100% (2 of 2)
Epididymis  Section images heterozygote 50% (1 of 2)
Lung  Section images heterozygote 100% (2 of 2)
Oviduct  Section images heterozygote Not available
Submandibular gland  Section images heterozygote 50% (1 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Trachea  Section images heterozygote 100% (2 of 2)
Uterus  Section images heterozygote 50% (1 of 2)
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Brainstem N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 0.0% (0 of 2)
Hippocampus N/A heterozygote 0.0% (0 of 2)
Hypothalamus N/A heterozygote 0.0% (0 of 2)
Kidney N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote Not available
Pancreas N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote Not available
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 0.0% (0 of 2)
Thalamus N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote 0.0% (0 of 2)
Vesicular gland N/A heterozygote Not available
White adipose tissue N/A heterozygote 0.0% (0 of 2)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 2)
N/A homozygote 0.0% (0 of 1)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
epididymis 12.78% (17 of 133)
esophagus 1.72% (7 of 408)
eye 0.0%
heart 0.34% (2 of 584)
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
mammary gland 0.0%
midbrain 0.0%
olfactory lobe 0.34% (2 of 584)
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
peripheral nervous system 0.34% (2 of 584)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
skeletal muscle 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
striatum 0.51% (3 of 584)
submandibular gland 1.53% (2 of 131)
testis 1.03% (6 of 584)
thalamus 0.0%
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
trachea 0.51% (3 of 584)
urinary bladder 0.0%
uterus 0.0%
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.18% (6 of 507)
dorsal root ganglion 1.69% (1 of 59)
ear 0.2% (1 of 507)
embryo 0.2% (1 of 508)
eye 0.2% (1 of 507)
footplate 0.2% (1 of 507)
forebrain 0.2% (1 of 507)
forelimb 0.2% (1 of 507)
fronto-nasal process 1.67% (1 of 60)
handplate 0.2% (1 of 507)
head 0.99% (5 of 507)
heart 0.2% (1 of 507)
hindbrain 1.18% (6 of 507)
hindlimb 0.2% (1 of 507)
liver 0.2% (1 of 502)
lung 0.2% (1 of 502)
mandibular process 0.2% (1 of 507)
maxillary process 0.2% (1 of 507)
midbrain 0.2% (1 of 507)
nose 1.3% (1 of 77)
oral cavity 0.2% (1 of 502)
skin 0.2% (1 of 507)
spinal cord 1.41% (1 of 71)
tail 0.2% (1 of 507)
tail somite group 0.2% (1 of 507)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

7 Images

X-ray

XRay Images Whole Body Lateral Orientation

7 Images

X-ray

XRay Images Forepaw

7 Images

Electrocardiogram (ECG)

Waveform Image

11 Images

X-ray

XRay Images Whole Body Dorso Ventral

7 Images

Adult LacZ

LacZ Images Section

8 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

7 Images

Combined SHIRPA and Dysmorphology

Images

1 Images

Human diseases caused by Rgs22 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rgs22 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Oocyte Maturation Defect 6
OMIM:618353
Oocyte Maturation Defect 7
OMIM:618550
Preimplantation Embryonic Lethality 1
OMIM:616814
Oocyte Maturation Defect 2
OMIM:616780
Progesterone Resistance
OMIM:264080
Female Infertility Due To Oocyte Meiotic Arrest
ORPHA:488191
Oocyte Maturation Defect 8
OMIM:619009
Oocyte Maturation Defect 9
OMIM:619011
Spermatogenic Failure 3
OMIM:606766
Oocyte Maturation Defect 4
OMIM:617743
Oocyte Maturation Defect 1
OMIM:615774
Oocyte Maturation Defect 5
OMIM:617996
Oocyte Maturation Defect 3
OMIM:617712
Spermatogenic Failure 27
OMIM:617965
Spermatogenic Failure 17
OMIM:617214
Premature Ovarian Failure 19
OMIM:619245
Preimplantation Embryonic Lethality 2
OMIM:617234
Nondisjunction
OMIM:158250
Hydatidiform Mole, Recurrent, 4
OMIM:618432
Hydatidiform Mole, Recurrent, 3
OMIM:618431
Spermatogenic Failure 5
OMIM:243060
Oocyte Maturation Defect 10
OMIM:619176
Spermatogenic Failure 11
OMIM:615081
Spermatogenic Failure 10
OMIM:614822
Spermatogenic Failure 32
OMIM:618115
Spermatogenic Failure 23
OMIM:617707
Spermatogenic Failure 22
OMIM:617706
Endometriosis, Susceptibility To, 1
OMIM:131200
Spermatogenic Failure 26
OMIM:617961
Spermatogenic Failure 33
OMIM:618152
Spermatogenic Failure 34
OMIM:618153
Spermatogenic Failure 20
OMIM:617593
Spermatogenic Failure 19
OMIM:617592
Spermatogenic Failure 35
OMIM:618341
Spermatogenic Failure 18
OMIM:617576
Spermatogenic Failure 55
OMIM:619380
Spermatogenic Failure 16
OMIM:617187
Spermatogenic Failure 21
OMIM:617644
Spermatogenic Failure 36
OMIM:618420
Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm
OMIM:608653
Asherman Syndrome
ORPHA:137686
Spermatogenic Failure 52
OMIM:619202
Spermatogenic Failure 12
OMIM:615413
Spermatogenic Failure 31
OMIM:618112
Spermatogenic Failure 53
OMIM:619258
Premature Ovarian Failure 6
OMIM:612310
Prolactin Deficiency, Isolated
OMIM:264110
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
OMIM:136580
Ring Chromosome Y Syndrome
ORPHA:261529
Blepharophimosis, Ptosis, And Epicanthus Inversus
OMIM:110100
Primary Ciliary Dyskinesia
ORPHA:244
Aromatase Deficiency
ORPHA:91
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
ORPHA:572333
Turner Syndrome
ORPHA:881
Mosaic Monosomy X
ORPHA:99228
Turner Syndrome Due To Structural X Chromosome Anomalies
ORPHA:99413
Monosomy X
ORPHA:99226

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rgs22

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rgs22.

No publications found that use IMPC mice or data for Rgs22.

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MGI Allele Allele Type Produced
Rgs22tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Rgs22tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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