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Gene: Ksr2 MGI:3610315

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

kinase suppressor of ras 2

Synonyms:

N/A

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ksr2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Ksr2 (0 diseases)
Human diseases predicted to be associated with Ksr2 (400 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ksr2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Triglyceride Storage Disease, Type Ii	Obesity	OMIM:190430
Maturity-Onset Diabetes Of The Young, Type 11	Overweight, Obesity	OMIM:613375
Obesity	Increased waist to hip ratio, Obesity	OMIM:601665
Spermatogenic Failure, X-Linked, 1	Obesity	OMIM:305700
Abdominal Obesity-Metabolic Syndrome 1	Abdominal obesity	OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2	Abdominal obesity	OMIM:605572
Prader-Willi syndrome (Type 1)	Truncal obesity	DECIPHER:14
Prader-Willi Syndrome (Type 2)	Truncal obesity	DECIPHER:53
Bardet-Biedl Syndrome 11	Obesity	OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome	Obesity	ORPHA:1078
Bardet-Biedl Syndrome 14	Obesity	OMIM:615991
Bardet-Biedl Syndrome 13	Obesity	OMIM:615990
Intellectual Developmental Disorder, X-Linked 97	Obesity	OMIM:300803
Obesity Due To Melanocortin 4 Receptor Deficiency	Childhood-onset truncal obesity, Obesity, Increased adipose tissue	ORPHA:71529
Summitt Syndrome	Obesity	OMIM:272350
Adiposis Dolorosa	Obesity, Painful subcutaneous lipomas	OMIM:103200
Dysplasia Epiphysealis Hemimelica	Overgrowth	OMIM:127800
Narcolepsy Type 1	Obesity	ORPHA:2073
Bardet-Biedl Syndrome 18	Obesity	OMIM:615995
Hypoinsulinemic Hypoglycemia With Hemihypertrophy	Truncal obesity, Obesity, Large for gestational age	OMIM:240900
Mitochondrial Complex Iv Deficiency, Nuclear Type 14	Obesity	OMIM:619058
Autism, Susceptibility To, X-Linked 6	Obesity	OMIM:300872
Body Mass Index Quantitative Trait Locus 20	Obesity, Tall stature	OMIM:618406
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome	Large for gestational age	ORPHA:356996
Severe Intellectual Disability-Hypotonia-Strabismus-Coarse Face-Planovalgus Syndrome	Obesity	ORPHA:436141
Bardet-Biedl Syndrome 10	Obesity	OMIM:615987
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type	Obesity	OMIM:309585
Hyperinsulinemic Hypoglycemia, Familial, 1	Large for gestational age	OMIM:256450
Cortisone Reductase Deficiency 2	Obesity	OMIM:614662
Coronary Artery Disease, Autosomal Dominant, 1	Obesity	OMIM:608320
Ankylosing Vertebral Hyperostosis With Tylosis	Obesity	ORPHA:2206
Adenocarcinoma Of The Esophagus	Obesity	ORPHA:99976
Short Stature Due To Primary Acid-Labile Subunit Deficiency	Truncal obesity	ORPHA:140941
Obesity And Hypopigmentation	Overgrowth, Obesity	OMIM:620195
Simpson-Golabi-Behmel Syndrome, Type 2	Inguinal hernia, Obesity	OMIM:300209
X-Linked Intellectual Disability-Hypogonadism-Ichthyosis-Obesity-Short Stature Syndrome	Hernia of the abdominal wall, Obesity	ORPHA:3055
Hyperinsulinemic Hypoglycemia, Familial, 2	Large for gestational age	OMIM:601820
Bardet-Biedl Syndrome 5	Obesity	OMIM:615983
Impaired Intellectual Development, Truncal Obesity, Retinal Dystrophy, And Micropenis Syndrome	Truncal obesity, Childhood-onset truncal obesity	OMIM:610156
Prolactin Deficiency With Obesity And Enlarged Testes	Obesity	OMIM:264120
Syndromic X-Linked Intellectual Disability 7	Obesity	ORPHA:85274
Hernández-Aguirre Negrete Syndrome	Obesity	ORPHA:2139
Obesity Due To Prohormone Convertase I Deficiency	Failure to thrive, Childhood-onset truncal obesity, Obesity, Increased adipose tissue	ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency	Failure to thrive, Childhood-onset truncal obesity, Obesity, Increased adipose tissue	ORPHA:71526
Cubitus Valgus With Impaired Intellectual Development And Unusual Facies	Truncal obesity	OMIM:300471
Intellectual Developmental Disorder, X-Linked 91	Obesity	OMIM:300577
Microduplication Xp11.22P11.23 Syndrome	Obesity	ORPHA:217377
Short Stature-Delayed Bone Age Due To Thyroid Hormone Metabolism Deficiency	Obesity	ORPHA:171706
Neurodevelopmental Disorder With Absent Speech And Movement And Behavioral Abnormalities	Obesity	OMIM:620270
Bardet-Biedl Syndrome 22	Obesity, Large for gestational age	OMIM:617119
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome	Obesity	ORPHA:88643
Obesity-Hypoventilation Syndrome	Obesity	OMIM:257500
Polycystic Ovary Syndrome 1	Obesity	OMIM:184700
11P15.4 Microduplication Syndrome	Obesity	ORPHA:300305
Hypogonadotropic Hypogonadism 27 Without Anosmia	Obesity	OMIM:619755
Xq27.3Q28 Duplication Syndrome	Truncal obesity, Failure to thrive	ORPHA:261483
Cortisone Reductase Deficiency 1	Obesity	OMIM:604931
Nephronophthisis 15	Obesity	OMIM:614845
Obesity, Hyperphagia, And Developmental Delay	Obesity	OMIM:613886
Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features	Failure to thrive in infancy, Obesity	OMIM:613670
Hypomagnesemia, Seizures, And Impaired Intellectual Development 1	Class III obesity	OMIM:616418
Intellectual Developmental Disorder With Behavioral Abnormalities And Craniofacial Dysmorphism With Or Without Seizures	Obesity	OMIM:618725
Bardet-Biedl Syndrome 16	Obesity	OMIM:615993
Bardet-Biedl Syndrome 7	Obesity	OMIM:615984
Symptomatic Form Of Coffin-Lowry Syndrome In Female Carriers	Obesity	ORPHA:276630
Trisomy 5P	Obesity	ORPHA:1742
Spastic Paraplegia And Psychomotor Retardation With Or Without Seizures	Obesity	OMIM:616756
Pituitary Hormone Deficiency, Combined Or Isolated, 7	Truncal obesity, Abdominal obesity	OMIM:618160
Coenzyme Q10 Deficiency, Primary, 2	Overweight, Obesity	OMIM:614651
Bardet-Biedl Syndrome 8	Obesity	OMIM:615985
Chromosome Xq21 Deletion Syndrome	Obesity	OMIM:303110
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency	Obesity	ORPHA:329249
Biemond Syndrome Type 2	Obesity	ORPHA:141333
Bardet-Biedl Syndrome 4	Obesity	OMIM:615982
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders	Overweight	OMIM:620065
Summitt Syndrome	Camptodactyly of finger, Tall stature, Obesity	ORPHA:3210
Morm Syndrome	Truncal obesity	ORPHA:75858
Morbid Obesity And Spermatogenic Failure	Obesity	OMIM:615703
Hypothyroidism, Central, With Testicular Enlargement	Overweight	OMIM:300888
Spastic Paraplegia-Intellectual Disability-Nystagmus-Obesity Syndrome	Obesity	ORPHA:521390
Leptin Deficiency Or Dysfunction	Obesity	OMIM:614962
Retinal Dystrophy And Obesity	Obesity	OMIM:616188
Mehmo Syndrome	Small for gestational age, Obesity	OMIM:300148
Impaired Intellectual Development, Obesity, Mandibular Prognathism, And Eye And Skin Anomalies	Obesity	OMIM:606772
Intellectual Developmental Disorder, X-Linked, Syndromic 11	Obesity	OMIM:300238
Bardet-Biedl Syndrome 2	Obesity	OMIM:615981
11Q22.2Q22.3 Microdeletion Syndrome	Obesity	ORPHA:444002
Bardet-Biedl Syndrome 21	Overweight, Obesity	OMIM:617406
Borjeson-Forssman-Lehmann Syndrome	Obesity	OMIM:301900
Temple Syndrome	Small for gestational age, Overweight, Flexion contracture, Obesity, Truncal obesity	OMIM:616222
Short Stature, Amelogenesis Imperfecta, And Skeletal Dysplasia With Scoliosis	Hip contracture, Inguinal hernia, Obesity, Truncal obesity, Enamel hypoplasia, Amelogenesis imper...	OMIM:618363
Immunodeficiency 61	Obesity	OMIM:300310
Polyneuropathy-Intellectual Disability-Acromicria-Premature Menopause Syndrome	Truncal obesity, Camptodactyly of finger	ORPHA:2928
X-Linked Intellectual Disability-Global Development Delay-Facial Dysmorphism-Sacral Caudal Remnant Syndrome	Lipoma, Obesity	ORPHA:480907
Mehmo Syndrome	Obesity	ORPHA:85282
Retinitis Pigmentosa	Atypical scarring of skin, Obesity	ORPHA:791
Hypogonadism-Mitral Valve Prolapse-Intellectual Disability Syndrome	Obesity	ORPHA:2233
X-Linked Intellectual Disability-Cubitus Valgus-Dysmorphism Syndrome	Truncal obesity	ORPHA:85280
Bardet-Biedl Syndrome 3	Obesity	OMIM:600151
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy	Truncal obesity, Large for gestational age	ORPHA:293964
Macrocephaly-Spastic Paraplegia-Dysmorphism Syndrome	Truncal obesity	ORPHA:2429
Intellectual Developmental Disorder, Autosomal Dominant 39	Obesity	OMIM:616521
Hydrocephalus-Obesity-Hypogonadism Syndrome	Obesity	ORPHA:2183
Rafiq Syndrome	Truncal obesity, Flexion contracture, Obesity	OMIM:614202
Laurence-Moon Syndrome	Obesity	OMIM:245800
Prader-Willi Syndrome Due To Imprinting Mutation	Obesity	ORPHA:177910
Baralle-Macken Syndrome	Obesity	OMIM:619255
Beta-Mercaptolactate Cysteine Disulfiduria	Umbilical hernia, Obesity	ORPHA:1035
Pseudopseudohypoparathyroidism	Enamel hypoplasia, Obesity	OMIM:612463
Lipodystrophy, Familial Partial, Type 6	Abdominal obesity, Lipodystrophy	OMIM:615980
Hepatic Veno-Occlusive Disease	Increased body weight	ORPHA:890
Pseudohypoparathyroidism, Type Ib	Obesity	OMIM:603233
Retinitis Pigmentosa-Intellectual Disability-Deafness-Hypogonadism Syndrome	Keloids, Obesity	ORPHA:3085
Chung-Jansen Syndrome	Obesity	OMIM:617991
Obesity Due To Sim1 Deficiency	Obesity	ORPHA:369873
Intellectual Disability-Obesity-Brain Malformations-Facial Dysmorphism Syndrome	Obesity	ORPHA:352530
X-Linked Intellectual Disability, Shashi Type	Obesity	ORPHA:85286
Atkin-Flaitz Syndrome	Obesity	ORPHA:1193
Peripheral Neuropathy, Autosomal Recessive, With Or Without Impaired Intellectual Development	Obesity	OMIM:618124
Temple Syndrome Due To Paternal 14Q32.2 Microdeletion	Obesity	ORPHA:254525
Congenital Myopathy 9A	Obesity	OMIM:618822
Short-Rib Thoracic Dysplasia 11 With Or Without Polydactyly	Obesity	OMIM:615633
Intellectual Disability-Obesity-Prognathism-Eye And Skin Anomalies Syndrome	Obesity	ORPHA:397973
Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome	Obesity	OMIM:601794
Clark-Baraitser Syndrome	Obesity	OMIM:617752
Laurence-Moon Syndrome	Obesity	ORPHA:2377
Ataxia-Oculomotor Apraxia Type 4	Obesity	ORPHA:459033
Wilson-Turner Syndrome	Truncal obesity	ORPHA:3459
Wagr Syndrome	Obesity	ORPHA:893
14Q11.2 Microduplication Syndrome	Obesity	ORPHA:261229
Bardet-Biedl Syndrome 19	Obesity	OMIM:615996
Retinitis Pigmentosa 51	Obesity	OMIM:613464
Colobomatous Microphthalmia-Obesity-Hypogenitalism-Intellectual Disability Syndrome	Obesity	ORPHA:363741
Body Mass Index Quantitative Trait Locus 19	Obesity	OMIM:617885
Bardet-Biedl Syndrome 9	Truncal obesity, Obesity	OMIM:615986
X-Linked Intellectual Disability, Stevenson Type	Obesity, Tall stature	ORPHA:85325
Temple Syndrome	Small for gestational age, Obesity	ORPHA:254516
Clark-Baraitser syndrome	Obesity, Tall stature	OMIM:300602
Neurodevelopmental Disorder With Hypotonia, Impaired Speech, And Behavioral Abnormalities	Obesity	OMIM:619854
Male Hypergonadotropic Hypogonadism-Intellectual Disability-Skeletal Anomalies Syndrome	Eunuchoid habitus, Obesity	ORPHA:2234
Craniosynostosis-Hydrocephalus-Arnold-Chiari Malformation Type I-Radioulnar Synostosis Syndrome	Umbilical hernia, Obesity	ORPHA:171839
Schaaf-Yang Syndrome	Failure to thrive in infancy, Flexion contracture, Obesity, Camptodactyly, Arthrogryposis multipl...	OMIM:615547
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13	Obesity	ORPHA:411515
Chromosome Xq27.3-Q28 Duplication Syndrome	Abdominal obesity, Small for gestational age	OMIM:300869
Intellectual Developmental Disorder With Dysmorphic Facies And Behavioral Abnormalities	Obesity, Tall stature	OMIM:618089
Spastic Paraplegia 11, Autosomal Recessive	Obesity	OMIM:604360
Narcolepsy 7	Obesity	OMIM:614250
Idiopathic Intracranial Hypertension	Obesity	ORPHA:238624
Temple Syndrome Due To Paternal 14Q32.2 Hypomethylation	Obesity	ORPHA:254531
Rhizomelic Limb Shortening With Dysmorphic Features	Obesity	OMIM:618821
48,Xxyy Syndrome	Inguinal hernia, Abnormal dental enamel morphology, Tall stature, Obesity	ORPHA:10
6Q16 Microdeletion Syndrome	Obesity	ORPHA:171829
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia	Obesity	OMIM:610628
Intellectual Developmental Disorder, X-Linked 107	Obesity	OMIM:301013
Hypothyroidism, Congenital, Nongoitrous, 6	Increased body mass index, Increased body weight	OMIM:614450
13Q12.3 Microdeletion Syndrome	Failure to thrive, Obesity, Congenital diaphragmatic hernia, Camptodactyly	ORPHA:412035
15Q24 Microdeletion Syndrome	Small for gestational age, Congenital diaphragmatic hernia, Obesity, Hernia, Failure to thrive	ORPHA:94065
Subaortic Stenosis-Short Stature Syndrome	Inguinal hernia, Obesity	ORPHA:3191
Chromosome 3Q29 Duplication Syndrome	Obesity	OMIM:611936
Megalencephaly	Truncal obesity	ORPHA:2477
Microtriplication 11Q24.1	Obesity	ORPHA:289522
Intellectual Developmental Disorder, Autosomal Recessive 13	Truncal obesity	OMIM:613192
Leptin Receptor Deficiency	Obesity	OMIM:614963
Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14	Truncal obesity, Small for gestational age, Obesity	ORPHA:96184
Spastic Paraplegia-Severe Developmental Delay-Epilepsy Syndrome	Obesity	ORPHA:464282
Urban-Rogers-Meyer Syndrome	Flexion contracture of toe, Camptodactyly of finger, Obesity	ORPHA:3409
Combined Oxidative Phosphorylation Deficiency 54	Obesity	OMIM:619737
Carpenter Syndrome	Umbilical hernia, Obesity	ORPHA:65759
Bardet-Biedl Syndrome 6	Obesity	OMIM:605231
Shox-Related Short Stature	Obesity	ORPHA:314795
Proprotein Convertase 1/3 Deficiency	Obesity	OMIM:600955
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome	Obesity	ORPHA:3077
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	Lipodystrophy, Achilles tendon contracture, Elbow flexion contracture, Obesity, Decreased cervica...	ORPHA:98855
Hydrocephalus-Costovertebral Dysplasia-Sprengel Anomaly Syndrome	Abnormal dental enamel morphology, Obesity	ORPHA:2180
Acth-Independent Macronodular Adrenal Hyperplasia 2	Abdominal obesity, Increased body weight	OMIM:615954
Intellectual Developmental Disorder, X-Linked 12	Increased body mass index, Small for gestational age, Truncal obesity	OMIM:300957
Chromosome 16P13.3 Deletion Syndrome, Proximal	Failure to thrive, Obesity	OMIM:610543
Mitochondrial Dna Depletion Syndrome 12B (Cardiomyopathic Type), Autosomal Recessive	Achilles tendon contracture, Obesity	OMIM:615418
Congenital Analbuminemia	Small for gestational age, Lipodystrophy, Obesity	ORPHA:86816
Intellectual Developmental Disorder, X-Linked, Syndromic 13	Flexion contracture, Wrist flexion contracture, Obesity	OMIM:300055
X-Linked Emery-Dreifuss Muscular Dystrophy	Lipodystrophy, Achilles tendon contracture, Elbow flexion contracture, Obesity, Decreased cervica...	ORPHA:98863
Emery-Dreifuss Muscular Dystrophy	Lipodystrophy, Achilles tendon contracture, Elbow flexion contracture, Obesity, Decreased cervica...	ORPHA:261
Autosomal Dominant Emery-Dreifuss Muscular Dystrophy	Lipodystrophy, Achilles tendon contracture, Elbow flexion contracture, Obesity, Decreased cervica...	ORPHA:98853
Xp22.13P22.2 Duplication Syndrome	Umbilical hernia, Truncal obesity, Congenital diaphragmatic hernia	ORPHA:284180
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome	Increased body weight	ORPHA:276608
Neurodevelopmental Disorder With Speech Impairment And Dysmorphic Facies	Obesity	OMIM:619056
X-Linked Intellectual Disability, Hedera Type	Obesity	ORPHA:93952
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome	Increased body weight	ORPHA:589905
Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities	Obesity, Tall stature	OMIM:618430
Short Stature-Brachydactyly-Obesity-Global Developmental Delay Syndrome	Obesity	ORPHA:464288
Cornelia De Lange Syndrome 5	Truncal obesity	OMIM:300882
Intellectual Disability-Balding-Patella Luxation-Acromicria Syndrome	Reduced subcutaneous adipose tissue, Truncal obesity, Flexion contracture of digit	ORPHA:3041
Macrocephaly/Autism Syndrome	Overgrowth, Obesity, Large for gestational age	OMIM:605309
Senior-Loken Syndrome 9	Obesity	OMIM:616629
Acrodysostosis 2 With Or Without Hormone Resistance	Obesity	OMIM:614613
Chromosome 2Q37 Deletion Syndrome	Obesity	OMIM:600430
Perrault Syndrome 4	Disproportionate tall stature, Obesity	OMIM:615300
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Impaired Intellectual Development Syndrome	Obesity	OMIM:194072
Distal 16P11.2 Microdeletion Syndrome	Obesity	ORPHA:261222
Pseudopseudohypoparathyroidism	Obesity	ORPHA:79445
Intellectual Developmental Disorder, X-Linked, Syndromic, Hackmann-Di Donato Type	Disproportionate tall stature, Abdominal obesity, Camptodactyly	OMIM:301039
Joubert Syndrome 37	Obesity	OMIM:619185
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly	Obesity	OMIM:615630
Ataxia-Oculomotor Apraxia 4	Obesity	OMIM:616267
Abdominal Obesity-Metabolic Syndrome 4	Obesity	OMIM:618620
Neurodevelopmental Disorder With Seizures, Spasticity, And Complete Or Partial Agenesis Of The Corpus Callosum	Overgrowth, Obesity	OMIM:620250
Neurodevelopmental Disorder With Hypotonia, Dysmorphic Facies, And Skin Abnormalities	Obesity	OMIM:620191
Tatton-Brown-Rahman Syndrome	Umbilical hernia, Proportionate tall stature, Obesity	ORPHA:404443
Thyroid Hormone Resistance, Generalized, Autosomal Recessive	Small for gestational age, Increased body weight	OMIM:274300
Morgagni-Stewart-Morel Syndrome	Obesity	ORPHA:77296
Momo Syndrome	Overgrowth, Obesity, Tall stature, Large for gestational age	ORPHA:2563
Insulin-Like Growth Factor I, Resistance To	Reduced subcutaneous adipose tissue, Truncal obesity, Lipodystrophy, Decreased body weight	OMIM:270450
Luscan-Lumish Syndrome	Overgrowth, Obesity	OMIM:616831
Laron Syndrome	Truncal obesity	ORPHA:633
Congenital-Onset Steinert Myotonic Dystrophy	Obesity, Decreased body weight	ORPHA:589821
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type	Abdominal obesity	OMIM:300354
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair	Obesity	OMIM:609734
48,Xxxy Syndrome	Inguinal hernia, Abnormal dental enamel morphology, Tall stature, Obesity	ORPHA:96263
Abdominal Obesity-Metabolic Syndrome 3	Truncal obesity, Abdominal obesity	OMIM:615812
Pseudohypoparathyroidism, Type Ic	Enamel hypoplasia, Obesity	OMIM:612462
Smith-Magenis Syndrome	Failure to thrive in infancy, Obesity	ORPHA:819
19P13.12 Microdeletion Syndrome	Arthrogryposis multiplex congenita, Obesity	ORPHA:254346
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency	Truncal obesity, Failure to thrive, Small for gestational age	ORPHA:73272
Pde4D Haploinsufficiency Syndrome	Abnormal dental enamel morphology, Obesity	ORPHA:439822
Blue Diaper Syndrome	Increased body weight	ORPHA:94086
Radio-Tartaglia Syndrome	Obesity	OMIM:619312
Carpenter Syndrome 1	Omphalocele, Obesity, Camptodactyly, Umbilical hernia, Joint contracture of the hand	OMIM:201000
Pseudohypoparathyroidism, Type Ia	Enamel hypoplasia, Obesity	OMIM:103580
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation	Overgrowth, Small for gestational age, Large for gestational age	ORPHA:254534
Ring Chromosome Y Syndrome	Obesity	ORPHA:261529
Man1B1-Cdg	Truncal obesity	ORPHA:397941
Kleefstra Syndrome Due To 9Q34 Microdeletion	Inguinal hernia, Failure to thrive, Femoral hernia, Obesity	ORPHA:96147
Proximal 16P11.2 Microdeletion Syndrome	Failure to thrive, Obesity, Congenital diaphragmatic hernia	ORPHA:261197
Momo Syndrome	Overgrowth, Obesity	OMIM:157980
Joubert Syndrome 8	Obesity	OMIM:612291
Metaphyseal Chondrodysplasia, Schmid Type	Obesity	ORPHA:174
Adiposis Dolorosa	Obesity	ORPHA:36397
Bdv Syndrome	Obesity	OMIM:619326
2Q37 Microdeletion Syndrome	Umbilical hernia, Obesity, Congenital diaphragmatic hernia	ORPHA:1001
X-Linked Intellectual Disability, Cabezas Type	Inguinal hernia, Camptodactyly of finger, Cachexia, Obesity	ORPHA:85293
Mody	Overweight, Obesity, Large for gestational age	ORPHA:552
Desbuquois Dysplasia 1	Obesity	OMIM:251450
Retinitis Pigmentosa 74	Obesity	OMIM:616562
Bardet-Biedl Syndrome 17	Obesity	OMIM:615994
Obesity Due To Congenital Leptin Deficiency	Obesity	ORPHA:66628
Rabin-Pappas Syndrome	Overgrowth, Obesity, Failure to thrive in infancy	OMIM:620155
Borjeson-Forssman-Lehmann Syndrome	Camptodactyly of toe, Truncal obesity	ORPHA:127
Den Hoed-De Boer-Voisin Syndrome	Overweight, Obesity, Decreased body weight, Enamel hypoplasia, Amelogenesis imperfecta	OMIM:619229
Retinal Dystrophy With Or Without Macular Staphyloma	Truncal obesity	OMIM:617547
Angelman Syndrome Due To A Point Mutation	Obesity	ORPHA:411511
Müllerian Aplasia And Hyperandrogenism	Obesity	ORPHA:247768
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 3	Obesity	OMIM:618395
Obesity Due To Leptin Receptor Gene Deficiency	Obesity	ORPHA:179494
Pituitary Adenoma 4, Acth-Secreting	Abdominal obesity, Obesity	OMIM:219090
8P23.1 Microdeletion Syndrome	Obesity, Congenital diaphragmatic hernia, Weight loss	ORPHA:251071
Low Phospholipid-Associated Cholelithiasis	Overweight, Obesity	ORPHA:69663
Marbach-Schaaf Neurodevelopmental Syndrome	Obesity	OMIM:619680
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities	Hip contracture, Elbow flexion contracture, Obesity	OMIM:618493
White-Sutton Syndrome	Failure to thrive, Obesity, Congenital diaphragmatic hernia	OMIM:616364
Very Long Chain Acyl-Coa Dehydrogenase Deficiency	Overweight, Small for gestational age, Obesity	ORPHA:26793
Bardet-Biedl Syndrome	Obesity	ORPHA:110
Silver-Russell Syndrome	Failure to thrive in infancy, Obesity, Cachexia	ORPHA:813
Neurodevelopmental Disorder With Or Without Variable Brain Abnormalities	Obesity	OMIM:618443
Deafness-Genital Anomalies-Metacarpal And Metatarsal Synostosis Syndrome	Truncal obesity	ORPHA:3224
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia	Obesity	OMIM:608624
Paternal Uniparental Disomy Of Chromosome 1	Abnormal dental enamel morphology, Obesity	ORPHA:251004
Down Syndrome	Umbilical hernia, Obesity	ORPHA:870
Smith-Magenis Syndrome	Increased body weight	OMIM:182290
Generalized Pustular Psoriasis	Overweight, Obesity	ORPHA:247353
Spastic Paraplegia, Intellectual Disability, Nystagmus, And Obesity	Obesity	OMIM:617296
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type	Increased body weight	OMIM:300860
Angelman Syndrome	Obesity	OMIM:105830
Sim1-Related Prader-Willi-Like Syndrome	Abdominal obesity, Failure to thrive, Obesity	ORPHA:398079
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion	Obesity	ORPHA:98794
3Q29 Microduplication Syndrome	Camptodactyly of toe, Obesity	ORPHA:251038
Achondroplasia	Obesity	ORPHA:15
Kleefstra Syndrome 1	Obesity	OMIM:610253
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome	Obesity	ORPHA:2235
White-Sutton Syndrome	Ventral hernia, Inguinal hernia, Obesity, Congenital diaphragmatic hernia	ORPHA:468678
Pruritic Urticarial Papules And Plaques Of Pregnancy	Increased body weight	ORPHA:64745
Wilson Disease	Failure to thrive, Increased body weight, Weight loss	ORPHA:905
Kleefstra Syndrome	Obesity, Hernia	ORPHA:261494
Septo-Optic Dysplasia Spectrum	Obesity	ORPHA:3157
Cohen Syndrome	Small for gestational age, Childhood-onset truncal obesity	OMIM:216550
Congenital Hyperinsulinism Due To Hnf4A Deficiency	Increased body weight, Large for gestational age	ORPHA:263455
Cntnap2-Related Developmental And Epileptic Encephalopathy	Obesity	ORPHA:163681
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease	Abdominal obesity, Dorsocervical fat pad, Increased body weight	ORPHA:189427
Acth-Independent Macronodular Adrenal Hyperplasia	Truncal obesity	OMIM:219080
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency	Obesity	ORPHA:209902
Pigmented Nodular Adrenocortical Disease, Primary, 2	Truncal obesity	OMIM:610475
Peripartum Cardiomyopathy	Obesity	ORPHA:563
Bardet-Biedl Syndrome 12	Obesity	OMIM:615989
Monosomy 13Q34	Obesity	ORPHA:96168
Wagro Syndrome	Obesity	OMIM:612469
Autosomal Recessive Spastic Paraplegia Type 11	Overweight, Obesity	ORPHA:2822
Bardet-Biedl Syndrome 1	Truncal obesity, Abdominal obesity, Obesity	OMIM:209900
Prader-Willi Syndrome	Abdominal obesity, Failure to thrive in infancy, Obesity	OMIM:176270
Angelman Syndrome	Obesity	ORPHA:72
Ulnar-Mammary Syndrome	Hernia of the abdominal wall, Camptodactyly of finger, Obesity	ORPHA:3138
Cohen Syndrome	Failure to thrive in infancy, Obesity	ORPHA:193
Microcephalic Primordial Dwarfism, Dauber Type	Obesity	ORPHA:319675
Insulinoma	Increased body weight	ORPHA:97279
Pigmented Nodular Adrenocortical Disease, Primary, 4	Increased body weight	OMIM:615830
Webb-Dattani Syndrome	Obesity	OMIM:615926
Magel2-Related Prader-Willi-Like Syndrome	Failure to thrive, Flexion contracture, Increased body weight, Abdominal obesity	ORPHA:398069
Combined Oxidative Phosphorylation Deficiency 15	Inguinal hernia, Obesity	OMIM:614947
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15	Failure to thrive, Small for gestational age, Obesity	ORPHA:98754
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion	Failure to thrive, Small for gestational age, Obesity	ORPHA:98793
Short Stature, Microcephaly, And Endocrine Dysfunction	Truncal obesity, Inguinal hernia	OMIM:616541
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2	Failure to thrive, Small for gestational age, Obesity	ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1	Failure to thrive, Small for gestational age, Obesity	ORPHA:177901
Diamond-Blackfan Anemia 21	Obesity	OMIM:620072
Sotos Syndrome	Overgrowth, Increased body weight, Tall stature	OMIM:117550
Neutral Lipid Storage Disease With Ichthyosis	Obesity	ORPHA:98907
Xylt1-Cdg	Truncal obesity	ORPHA:370930
7Q11.23 Microduplication Syndrome	Inguinal hernia, Obesity, Congenital diaphragmatic hernia	ORPHA:96121
Chops Syndrome	Obesity	OMIM:616368
Aromatase Deficiency	Eunuchoid habitus, Obesity, Tall stature	ORPHA:91
Dysbetalipoproteinemia	Obesity	ORPHA:412
Pigmented Nodular Adrenocortical Disease, Primary, 1	Truncal obesity	OMIM:610489
Alstrom Syndrome	Truncal obesity	OMIM:203800
Kallmann Syndrome	Obesity	ORPHA:478
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation	Truncal obesity, Obesity	ORPHA:466950
Desbuquois Dysplasia 2	Truncal obesity	OMIM:615777
Odontochondrodysplasia 2 With Hearing Loss And Diabetes	Dentinogenesis imperfecta, Obesity	OMIM:619269
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome	Obesity	ORPHA:369837
Metaphyseal Dysostosis, Impaired Intellectual Development, And Conductive Deafness	Obesity	OMIM:250420
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies	Umbilical hernia, Obesity	OMIM:301066
Prader-Willi Syndrome Due To Translocation	Obesity	ORPHA:177907
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies	Inguinal hernia, Obesity	OMIM:618653
Intellectual Developmental Disorder, Autosomal Dominant 29	Obesity	OMIM:616078
Distal Deletion 12Q	Elbow flexion contracture, Proportionate tall stature, Failure to thrive in infancy, Obesity	ORPHA:96149
Microcephalic Osteodysplastic Primordial Dwarfism Type Ii	Truncal obesity	ORPHA:2637
Microcephalic Osteodysplastic Primordial Dwarfism, Type Ii	Truncal obesity, Enamel hypoplasia	OMIM:210720
Pseudohypoparathyroidism Type 1C	Enamel hypoplasia, Obesity	ORPHA:79444
Sheehan Syndrome	Obesity	ORPHA:91355
Adrenocortical Carcinoma	Increased body weight, Weight loss	ORPHA:1501
Intellectual Disability-Seizures-Macrocephaly-Obesity Syndrome	Failure to thrive, Obesity	ORPHA:369950
Kabuki Syndrome	Failure to thrive, Obesity, Congenital diaphragmatic hernia	ORPHA:2322
Bloom Syndrome	Adipose tissue loss, Abdominal obesity, Small for gestational age	ORPHA:125
Helsmoortel-Van Der Aa Syndrome	Truncal obesity, Failure to thrive, Obesity	OMIM:615873
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis	Truncal obesity, Flexion contracture, Limb joint contracture	OMIM:301072
Bardet-Biedl Syndrome 20	Obesity	OMIM:619471
Thyrotoxic Periodic Paralysis	Obesity, Weight loss	ORPHA:79102
Gaisböck Syndrome	Overweight, Obesity	ORPHA:90041
Pseudohypoparathyroidism Type 1A	Enamel hypoplasia, Obesity	ORPHA:79443
1P21.3 Microdeletion Syndrome	Obesity	ORPHA:293948
Wac-Related Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome	Obesity	ORPHA:466943
Developmental Delay, Impaired Speech, And Behavioral Abnormalities	Overweight, Failure to thrive, Obesity, Decreased body weight	OMIM:619475
Prader-Willi Syndrome	Abdominal obesity, Failure to thrive	ORPHA:739
Craniopharyngioma	Obesity	ORPHA:54595
22Q11.2 Deletion Syndrome	Inguinal hernia, Abnormal dental enamel morphology, Obesity, Umbilical hernia, Failure to thrive	ORPHA:567
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency	Failure to thrive, Increased body weight	ORPHA:264580
Adnp Syndrome	Umbilical hernia, Inguinal hernia, Truncal obesity	ORPHA:404448
Myhre Syndrome	Small for gestational age, Obesity, Camptodactyly	OMIM:139210
Beckwith-Wiedemann Syndrome	Omphalocele, Inguinal hernia, Congenital diaphragmatic hernia, Large for gestational age, Obesity...	ORPHA:116
White-Kernohan Syndrome	Obesity	OMIM:619426
Cushing Disease	Truncal obesity, Abdominal obesity, Dorsocervical fat pad, Increased body weight	ORPHA:96253
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency	Increased body weight	ORPHA:79240
Xq21 Microdeletion Syndrome	Obesity	ORPHA:1435
6Q Terminal Deletion Syndrome	Failure to thrive, Obesity	ORPHA:75857
Insulin-Resistance Syndrome Type B	Abnormality of body weight, Decreased body weight, Increased body weight, Weight loss	ORPHA:2298
17Q24.2 Microdeletion Syndrome	Truncal obesity, Failure to thrive in infancy	ORPHA:529962
Microcephaly, Epilepsy, And Diabetes Syndrome 1	Obesity	OMIM:614231
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome	Obesity	ORPHA:444077
Lysinuric Protein Intolerance	Truncal obesity, Failure to thrive	OMIM:222700
Meningioma	Obesity	ORPHA:2495
Monosomy 22Q13.3	Umbilical hernia, Obesity	ORPHA:48652
Neutral Lipid Storage Myopathy	Obesity	ORPHA:98908
Rubinstein-Taybi Syndrome 1	Small for gestational age, Flexion contracture, Truncal obesity, Keloids, Enamel hypoplasia, Fail...	OMIM:180849
Carpenter Syndrome 2	Umbilical hernia, Obesity, Camptodactyly, Knee flexion contracture	OMIM:614976
1P36 Deletion Syndrome	Failure to thrive, Camptodactyly of finger, Obesity	ORPHA:1606
Short Stature, Brachydactyly, Impaired Intellectual Development, And Seizures	Failure to thrive, Obesity	OMIM:617157
45,X/46,Xy Mixed Gonadal Dysgenesis	Obesity	ORPHA:1772
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion	Keloids, Failure to thrive, Obesity	ORPHA:353281
Turner Syndrome Due To Structural X Chromosome Anomalies	Atypical scarring of skin, Failure to thrive in infancy, Obesity	ORPHA:99413
Turner Syndrome	Atypical scarring of skin, Failure to thrive in infancy, Obesity	ORPHA:881
Mosaic Monosomy X	Atypical scarring of skin, Failure to thrive in infancy, Obesity	ORPHA:99228
Monosomy X	Atypical scarring of skin, Failure to thrive in infancy, Obesity	ORPHA:99226
Hellp Syndrome	Increased body weight	ORPHA:244242
Ulnar-Mammary Syndrome	Inguinal hernia, Elbow flexion contracture, Obesity	OMIM:181450
Chronic Thromboembolic Pulmonary Hypertension	Obesity	ORPHA:70591
Tako-Tsubo Cardiomyopathy	Obesity	ORPHA:66529
Witteveen-Kolk Syndrome	Inguinal hernia, Small for gestational age, Congenital diaphragmatic hernia, Obesity, Contracture...	OMIM:613406
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency	Keloids, Failure to thrive, Obesity, Corneal scarring	ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations	Keloids, Failure to thrive, Obesity, Corneal scarring	ORPHA:353277
Williams Syndrome	Inguinal hernia, Failure to thrive in infancy, Abnormal dental enamel morphology, Obesity, Umbili...	ORPHA:904
Growth Restriction, Hypoplastic Kidneys, Alopecia, And Distinctive Facies	Abdominal obesity, Flexion contracture	OMIM:619321
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome	Obesity	ORPHA:293987
Chromosome 1P36 Deletion Syndrome, Distal	Obesity, Camptodactyly of finger, Camptodactyly	OMIM:607872
Digeorge Syndrome	Umbilical hernia, Inguinal hernia, Femoral hernia, Obesity	OMIM:188400
Williams-Beuren Syndrome	Inguinal hernia, Failure to thrive in infancy, Flexion contracture, Obesity, Umbilical hernia	OMIM:194050
Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb	Truncal obesity, Failure to thrive, Camptodactyly	OMIM:612474
Cushing Syndrome Due To Ectopic Acth Secretion	Dorsocervical fat pad, Increased body weight, Weight loss, Truncal obesity, Abdominal obesity	ORPHA:99889
Cornelia De Lange Syndrome	Truncal obesity, Failure to thrive, Congenital diaphragmatic hernia	ORPHA:199
Carney Complex	Abdominal obesity, Dorsocervical fat pad, Increased body weight, Tall stature	ORPHA:1359
Intellectual Disability-Hypotonic Facies Syndrome, X-Linked, 1	Obesity	OMIM:309580
Pallister-Killian Syndrome	Omphalocele, Inguinal hernia, Congenital diaphragmatic hernia, Flexion contracture, Obesity, Camp...	OMIM:601803
Primrose Syndrome	Hip contracture, Flexion contracture, Truncal obesity, Knee flexion contracture	OMIM:259050
Alström Syndrome	Truncal obesity, Dorsocervical fat pad, Obesity	ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ksr2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ksr2.

No publications found that use IMPC mice or data for Ksr2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Ksr2^{tm45131(L1L2_gt0)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Ksr2^{tm1a(KOMP)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells
Ksr2^{tm1e(KOMP)Wtsi}	Targeted, non-conditional allele	ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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