Gene Summary

Name:
transmembrane protein 132B
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased lung compliance Tmem132bem1(IMPC)Ccpcz HOM Early adult 7.65×10-05
hyperactivity Tmem132bem1(IMPC)Ccpcz HOM Early adult 2.36×10-05
abnormal cholesterol homeostasis Tmem132bem1(IMPC)Ccpcz HOM Early adult 1.52×10-09
increased body weight Tmem132bem1(IMPC)Ccpcz HOM Early adult 3.15×10-06
abnormal liver morphology Tmem132bem1(IMPC)Ccpcz HOM Early adult 0.00
decreased exploration in new environment Tmem132bem1(IMPC)Ccpcz HOM Early adult 1.71×10-08

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

15 Images

X-ray

XRay Images Forepaw

15 Images

X-ray

XRay Images Hind Leg and Hip

30 Images

X-ray

XRay Images Skull Lateral Orientation

15 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

X-ray

XRay Images Whole Body Dorso Ventral

30 Images

Human diseases caused by Tmem132b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tmem132b by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Short attention span, Hyperactivity DECIPHER:19
Intellectual Developmental Disorder, Autosomal Recessive 3
Short attention span, Hyperactivity OMIM:608443
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Bruxism, Large for gestational age, Aggressive behavior, Hyperactivity ORPHA:356996
Schizophrenia 15
Hyperactivity OMIM:613950
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity, Decreased body weight OMIM:616311
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Intellectual Developmental Disorder, Autosomal Recessive 37
Bruxism, Aggressive behavior, Hyperactivity OMIM:615493
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features
Self-injurious behavior, Inflexible adherence to routines, Failure to thrive in infancy, Obesity,... OMIM:613670
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders
Attention deficit hyperactivity disorder, Overweight, Motor stereotypy OMIM:620065
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Large for gestational age, Truncal obesity, Increased hepatic glycogen content ORPHA:293964
Smith-Magenis syndrome
Motor stereotypy, Hyperactivity, Self-mutilation DECIPHER:8
Intellectual Developmental Disorder, X-Linked 109
Stereotypical body rocking, Recurrent hand flapping, Agitation, Aggressive behavior, Hyperactivit... OMIM:309548
Fraxe Intellectual Disability
Stereotypical body rocking, Recurrent hand flapping, Impulsivity, Aggressive behavior, Hyperactiv... ORPHA:100973
Mitochondrial Complex Iv Deficiency, Nuclear Type 14
Obesity, Cognitive impairment OMIM:619058
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Obesity And Hypopigmentation
Overgrowth, Obesity, Polyphagia, Hepatic steatosis OMIM:620195
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type
Obesity, Emotional lability OMIM:309585
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age, Nesidioblastosis, Pancreatic islet-cell hyperplasia OMIM:601820
Morm Syndrome
Aggressive behavior, Hyperactivity, Truncal obesity ORPHA:75858
Encephalopathy, Progressive, With Or Without Lipodystrophy
Hepatomegaly, Mental deterioration, Hyperactivity, Hypertriglyceridemia OMIM:615924
Obesity Due To Sim1 Deficiency
Memory impairment, Obesity, Polyphagia, Attention deficit hyperactivity disorder, Cognitive impai... ORPHA:369873
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age, Pancreatic islet-cell hyperplasia OMIM:256450
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity, Impulsivity OMIM:301008
Glycine Encephalopathy 1
Irritability, Aggressive behavior, Hyperactivity, Restlessness, Impulsivity OMIM:605899
Neurodevelopmental Disorder With Absent Speech And Movement And Behavioral Abnormalities
Aggressive behavior, Obesity, Hyperactivity OMIM:620270
Coronary Artery Disease, Autosomal Dominant, 1
Obesity, Hypercholesterolemia OMIM:608320
Obesity Due To Melanocortin 4 Receptor Deficiency
Polyphagia, Obesity, Childhood-onset truncal obesity, Hypertriglyceridemia ORPHA:71529
Hartnup Disorder
Attention deficit hyperactivity disorder, Emotional lability, Hyperactivity OMIM:234500
Bardet-Biedl Syndrome 5
Obesity, Cognitive impairment OMIM:615983
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Self-injurious behavior, Aggressive behavior, Hyperactivity OMIM:619031
Immunodeficiency 61
Attention deficit hyperactivity disorder, Obesity OMIM:300310
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Aggressive behavior, Obesity, Polyphagia ORPHA:329249
Macrosomia-Microphthalmia-Cleft Palate Syndrome
Hepatomegaly, Large for gestational age ORPHA:2432
Low Phospholipid-Associated Cholelithiasis
Intrahepatic cholestasis, Cholelithiasis, Biliary cirrhosis, Elevated circulating hepatic transam... ORPHA:69663
Developmental And Epileptic Encephalopathy 43
Attention deficit hyperactivity disorder, Hyperactivity, Impulsivity OMIM:617113
Wilson Disease
Depression, Elevated circulating hepatic transaminase concentration, Failure to thrive, Hepatitis... ORPHA:905
Intellectual Developmental Disorder With Behavioral Abnormalities And Craniofacial Dysmorphism With Or Without Seizures
Attention deficit hyperactivity disorder, Obesity OMIM:618725
Body Mass Index Quantitative Trait Locus 20
Tall stature, Obesity, Polyphagia OMIM:618406
Adiposis Dolorosa
Obesity, Depression OMIM:103200
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear-induced behavior, Obesity, Irritability, Aggressive behavior, Hyperactivity, Anorex... ORPHA:3077
Hepatic Veno-Occlusive Disease
Increased body weight, Hepatomegaly, Jaundice, Elevated circulating hepatic transaminase concentr... ORPHA:890
Morbid Obesity And Spermatogenic Failure
Obesity, Hypercholesterolemia, Hepatic steatosis, Hypertriglyceridemia OMIM:615703
Landau-Kleffner Syndrome
Memory impairment, Depression, Short attention span, Emotional lability, Aggressive behavior, Att... ORPHA:98818
Obesity, Hyperphagia, And Developmental Delay
Polyphagia, Obesity, Motor stereotypy OMIM:613886
Citrullinemia Type Ii
Hepatic fibrosis, Memory impairment, Decreased body mass index, Elevated circulating hepatic tran... ORPHA:247585
Intellectual Developmental Disorder, Autosomal Dominant 67
Compulsive behaviors, Attention deficit hyperactivity disorder, Motor tics, Hyperactivity OMIM:619927
Intellectual Developmental Disorder, X-Linked 107
Aggressive behavior, Attention deficit hyperactivity disorder, Obesity, Hyperactivity OMIM:301013
Phenylketonuria
Depression, Self-mutilation, Irritability, Aggressive behavior, Attention deficit hyperactivity d... OMIM:261600
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Self-injurious behavior, Memory impairment, Inappropriate behavior, Aggressive behavior, Attentio... OMIM:619827
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Obesity, Inappropriate laughter, Short attention span, Polyphagia, Hyperactivity ORPHA:411515
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Large for gestational age, Obesity, Truncal obesity OMIM:240900
Cntnap2-Related Developmental And Epileptic Encephalopathy
Mental deterioration, Abnormal temper tantrums, Obesity, Low frustration tolerance, Self-mutilati... ORPHA:163681
Obesity Due To Prohormone Convertase I Deficiency
Failure to thrive, Cholestasis, Obesity, Polyphagia, Childhood-onset truncal obesity ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Failure to thrive, Cholestasis, Obesity, Polyphagia, Childhood-onset truncal obesity ORPHA:71526
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Progressive neurologic deterioration, Increased body weight, Pancreatic islet-cell hyperplasia, A... ORPHA:276608
Leptin Receptor Deficiency
Obesity, Abnormal eating behavior, Emotional lability, Aggressive behavior, Polyphagia OMIM:614963
Bardet-Biedl Syndrome 22
Polyphagia, Obesity, Large for gestational age OMIM:617119
Cortisone Reductase Deficiency 2
Obesity, Low tetrahydrocortisol (THF) plus 5-alpha-THF/tetrahydrocortisone (THE) ratio OMIM:614662
Narcolepsy Type 1
Transient global amnesia, Depression, Obesity, Restless legs, Attention deficit hyperactivity dis... ORPHA:2073
Obesity-Hypoventilation Syndrome
Obesity, Hypoventilation OMIM:257500
Juvenile Huntington Disease
Depression, Irritability, Weight loss, Hyperactivity, Dementia ORPHA:248111
Intellectual Developmental Disorder, Autosomal Recessive 38
Recurrent hand flapping, Self-mutilation, Diminished ability to concentrate, Aggressive behavior,... OMIM:615516
14Q11.2 Microduplication Syndrome
Polyphagia, Attention deficit hyperactivity disorder, Obesity, Aggressive behavior ORPHA:261229
Pigmented Nodular Adrenocortical Disease, Primary, 2
Mental deterioration, Depression, Increased circulating cortisol level, Primary hypercortisolism,... OMIM:610475
Body Mass Index Quantitative Trait Locus 19
Polyphagia, Obesity, Hyperlipidemia, Hypertriglyceridemia OMIM:617885
Intellectual Developmental Disorder, Autosomal Dominant 39
Polyphagia, Obesity, Aggressive behavior, Self-mutilation OMIM:616521
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity, Inflexible adherence to routines OMIM:301076
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Acute hepatic steatosis, Hepatitis, Cholestasis, Obesity, Hepatic steatosis, Hypercholesterolemia... ORPHA:209902
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Increased body weight, Attention deficit hyperactivity disorder, Impulsivity ORPHA:589905
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Smith-Magenis Syndrome
Head-banging, Onychotillomania, Self-mutilation, Increased body weight, Hypercholesterolemia, Hyp... OMIM:182290
Nephronophthisis 15
Obesity, Elevated circulating hepatic transaminase concentration OMIM:614845
Neurodevelopmental Disorder With Poor Growth And Behavioral Abnormalities
Depression, Failure to thrive, Short attention span, Aggressive behavior, Attention deficit hyper... OMIM:620242
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased body weight, Depression, Increased circulating cortisol level, Abdominal obesity OMIM:615954
Coenzyme Q10 Deficiency, Primary, 2
Obesity, Overweight, Bulimia OMIM:614651
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Increased body weight, Attention deficit hyperactivity disorder, Small for gestational age OMIM:274300
Intellectual Developmental Disorder, Autosomal Dominant 72
Tall stature, Obesity, Overfriendliness, Polyphagia, Attention deficit hyperactivity disorder OMIM:620439
Ataxia-Oculomotor Apraxia Type 4
Obesity, Short attention span, Cognitive impairment ORPHA:459033
Developmental Delay, Language Impairment, And Ocular Abnormalities
Frequent temper tantrums, Aggressive behavior, Attention deficit hyperactivity disorder, Hyperact... OMIM:620141
Graves Disease
Polyphagia, Weight loss, Hyperactivity, Irritability OMIM:275000
Pitt-Hopkins-Like Syndrome 1
Aggressive behavior, Attention deficit hyperactivity disorder, Hyperactivity, Hyperventilation, P... OMIM:610042
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Elevated circulating hepatic transaminase concentration, Large for gestational age, Pancreatic is... ORPHA:263455
Pigmented Nodular Adrenocortical Disease, Primary, 4
Depression, Increased circulating cortisol level, Primary hypercortisolism, Emotional lability, I... OMIM:615830
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Memory impairment, Depression, Increased circulating cortisol level, Hyperaldosteronism, Hyperlip... ORPHA:189427
Morgagni-Stewart-Morel Syndrome
Memory impairment, Depression, Obesity, Hypercholesterolemia, Cognitive impairment ORPHA:77296
Intellectual Developmental Disorder, Autosomal Dominant 45
Slender build, Recurrent hand flapping, Attention deficit hyperactivity disorder, Hyperactivity, ... OMIM:617600
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Cholestasis, Polyphagia, Obesity, Decreased circulating cortisol level OMIM:609734
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Self-injurious behavior, Abnormal temper tantrums, Depression, Short attention span, Recurrent ha... ORPHA:449291
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Hepatic fibrosis, Portal fibrosis, Elevated circulating hepatic transaminase concentration, Failu... ORPHA:264580
Ataxia-Oculomotor Apraxia 4
Obesity, Hypercholesterolemia, Cognitive impairment OMIM:616267
Argininemia
Portal fibrosis, Micronodular cirrhosis, Cholestasis, Irritability, Hyperactivity, Anorexia, Hepa... OMIM:207800
Hypothyroidism, Congenital, Nongoitrous, 6
Increased body weight, Increased body mass index OMIM:614450
Joubert Syndrome 8
Prolonged neonatal jaundice, Hepatomegaly, Obesity, Hyperventilation OMIM:612291
Insulinoma
Increased body weight, Transient global amnesia, Polyphagia, Abnormality of the pancreatic islet ... ORPHA:97279
Macrocephaly/Autism Syndrome
Obesity, Large for gestational age, Short attention span, Splenomegaly, Overgrowth, Hepatomegaly OMIM:605309
Insulin-Like Growth Factor I Deficiency
Short attention span, Hyperactivity, Decreased body weight OMIM:608747
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Hepatic fibrosis, Elevated circulating hepatic transaminase concentration, Splenomegaly, Increase... ORPHA:79240
Wagro Syndrome
Obesity, Emotional lability, Low frustration tolerance, Polyphagia, Aggressive behavior, Compulsi... OMIM:612469
Obesity Due To Leptin Receptor Gene Deficiency
Polyphagia, Obesity, Emotional lability, Hypertriglyceridemia ORPHA:179494
Senior-Loken Syndrome 9
Cholestasis, Hepatic fibrosis, Obesity OMIM:616629
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight, Aggressive behavior, Self-injurious behavior OMIM:300860
Adrenocortical Carcinoma
Increased circulating cortisol level, Hyperaldosteronism, Irritability, Increased body weight, El... ORPHA:1501
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Diffuse pancreatic islet hyperplasia, Increased circulating cortisol level, Large for gestational... ORPHA:79644
Blue Diaper Syndrome
Increased body weight, Elevated circulating hepatic transaminase concentration ORPHA:94086
Dysbetalipoproteinemia
Obesity, Xanthelasma, Hepatic steatosis, Hypercholesterolemia, Hypertriglyceridemia, Hepatomegaly... ORPHA:412
Sotos Syndrome
Tall stature, Increased body weight, Aggressive behavior, Attention deficit hyperactivity disorde... OMIM:117550
Magel2-Related Prader-Willi-Like Syndrome
Abnormal temper tantrums, Failure to thrive, Increased body weight, Polyphagia, Skin-picking, Cog... ORPHA:398069
Resistance To Thyrotropin-Releasing Hormone Syndrome
Prolonged neonatal jaundice, Depression, Overweight ORPHA:99832
Mody
Pancreatic hypoplasia, Exocrine pancreatic insufficiency, Obesity, Large for gestational age, Hep... ORPHA:552
Abdominal Obesity-Metabolic Syndrome 4
Obesity, Hypertriglyceridemia OMIM:618620
Familial Hyperthyroidism Due To Mutations In Tsh Receptor
Weight loss, Small for gestational age, Agitation, Hyperactivity ORPHA:424
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Self-injurious behavior, Depression, Polydipsia, Elevated circulating hepatic transaminase concen... ORPHA:293987
1P21.3 Microdeletion Syndrome
Self-injurious behavior, Obesity, Abnormal eating behavior, Self-mutilation, Aggressive behavior ORPHA:293948
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Cushing Disease
Memory impairment, Depression, Increased circulating cortisol level, Emotional lability, Increase... ORPHA:96253
Insulin-Resistance Syndrome Type B
Biliary cirrhosis, Abnormality of body weight, Decreased body weight, Increased body weight, Weig... ORPHA:2298
Cushing Syndrome Due To Ectopic Acth Secretion
Memory impairment, Depression, Increased circulating cortisol level, Anorexia, Pancreatic adenoca... ORPHA:99889
Histidinemia
Hyperactivity ORPHA:2157
Hellp Syndrome
Increased body weight, Elevated circulating hepatic transaminase concentration ORPHA:244242
Carney Complex
Increased circulating cortisol level, Tall stature, Increased body weight, Abdominal obesity, Neo... ORPHA:1359

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tmem132b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tmem132b.

No publications found that use IMPC mice or data for Tmem132b.

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MGI Allele Allele Type Produced
Tmem132bem1(IMPC)Ccpcz Deletion Mice

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