Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
GDNF family receptor alpha like
Synonyms:
GRAL

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gfral mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gfral by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Obesity Due To Melanocortin 4 Receptor Deficiency
Hyperinsulinemia, Polyphagia, Hypertriglyceridemia, Type II diabetes mellitus, Childhood-onset tr... ORPHA:71529
Body Mass Index Quantitative Trait Locus 20
Hyperinsulinemia, Polyphagia, Obesity OMIM:618406
Macrosomia Adiposa Congenita
Large for gestational age, Polyphagia, Obesity OMIM:248100
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Hyperinsulinemia, Polyphagia, Obesity ORPHA:329249
Hyperinsulinism Due To Hnf1A Deficiency
Hypoglycemic seizures, Fasting hypoglycemia, Maturity-onset diabetes of the young, Maternal diabe... ORPHA:324575
Obesity Due To Sim1 Deficiency
Glucose intolerance, Hyperinsulinemia, Polyphagia, Obesity ORPHA:369873
Type 1 Diabetes Mellitus
Hyperglycemia, Polydipsia, Polyphagia, Diabetes mellitus OMIM:222100
Obesity, Hyperphagia, And Developmental Delay
Polyphagia, Obesity OMIM:613886
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hypoglycemic seizures, Fasting hypoglycemia, Abnormal oral glucose tolerance, Maternal diabetes, ... ORPHA:276580
Leptin Receptor Deficiency
Abnormal eating behavior, Diabetes mellitus, Polyphagia, Obesity OMIM:614963
Obesity Due To Prohormone Convertase I Deficiency
Hypoglycemic seizures, Hyperinsulinemia, Polyphagia, Failure to thrive, Childhood-onset truncal o... ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Hypoglycemic seizures, Hyperinsulinemia, Polyphagia, Failure to thrive, Childhood-onset truncal o... ORPHA:71526
Leptin Deficiency Or Dysfunction
Abnormal eating behavior, Polyphagia, Obesity OMIM:614962
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Hypoglycemic seizures, Polyphagia, Obesity OMIM:609734
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemic seizures, Fasting hypoglycemia, Hyperinsulinemic hypoglycemia, Polyphagia, Hyperinsu... ORPHA:276575
Renal Glucosuria
Polydipsia, Polyphagia, Glycosuria OMIM:233100
Hyperinsulinism Due To Ucp2 Deficiency
Hypoglycemic seizures, Hyperinsulinemic hypoglycemia, Polyphagia, Hypoketotic hypoglycemia, Recur... ORPHA:276556
Hypotonia-Cystinuria Syndrome
Polyphagia, Failure to thrive ORPHA:163690
Temple Syndrome
Polyphagia, Small for gestational age, Type II diabetes mellitus, Recurrent hypoglycemia, Obesity ORPHA:254516
Obesity Due To Congenital Leptin Deficiency
Hyperinsulinemia, Polyphagia, Insulin-resistant diabetes mellitus, Hypertriglyceridemia, Obesity ORPHA:66628
Prader-Willi Syndrome Due To Imprinting Mutation
Polyphagia, Obesity ORPHA:177910
Coronary Artery Disease, Autosomal Dominant 2
Hypercholesterolemia, Glucose intolerance, Impaired glucose tolerance, Hypertriglyceridemia, Diab... OMIM:610947
Obesity Due To Leptin Receptor Gene Deficiency
Hyperinsulinemia, Polyphagia, Insulin-resistant diabetes mellitus, Hypertriglyceridemia, Obesity ORPHA:179494
Bardet-Biedl Syndrome 9
Polyphagia, Truncal obesity, Hyperglycemia, Polydipsia, Obesity OMIM:615986
Glycogen Storage Disease Vi
Hypercholesterolemia, Hypoglycemia, Failure to thrive in infancy, Hypertriglyceridemia, Hyperlipi... OMIM:232700
Insulinoma
Hyperinsulinemic hypoglycemia, Polyphagia, Hyperinsulinemia, Fasting hyperinsulinemia, Nonketotic... ORPHA:97279
Graves Disease, Susceptibility To, 1
Polyphagia, Weight loss OMIM:275000
Pick Disease Of Brain
Polyphagia OMIM:172700
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Polyphagia, Obesity ORPHA:411515
6Q16 Microdeletion Syndrome
Polyphagia, Obesity ORPHA:171829
Frontotemporal Dementia
Polyphagia OMIM:600274
Hypotonia-Cystinuria Syndrome
Neonatal hypoglycemia, Polyphagia, Failure to thrive OMIM:606407
Huntington Disease
Choking episodes, Decreased body mass index, Polyphagia, Weight loss, Oral-pharyngeal dysphagia ORPHA:399
Schaaf-Yang Syndrome
Polyphagia, Failure to thrive in infancy, Obesity OMIM:615547
Secondary Short Bowel Syndrome
Failure to thrive, Weight loss, Polyphagia, Steatorrhea ORPHA:95427
Man1B1-Cdg
Truncal obesity, Polyphagia ORPHA:397941
Cebalid Syndrome
Polyphagia OMIM:618774
Chromosome 22Q13 Duplication Syndrome
Polyphagia OMIM:615538
Hypertriglyceridemia 1
Hypertriglyceridemia, Glucose intolerance OMIM:145750
Hyperlipoproteinemia, Type Iv
Hypertriglyceridemia, Glucose intolerance OMIM:144600
Luscan-Lumish Syndrome
Polyphagia, Obesity OMIM:616831
2Q23.1 Microdeletion Syndrome
Polyphagia ORPHA:228402
Trisomy 18P
Polyphagia ORPHA:1715
X-Linked Acrogigantism
Abnormal oral glucose tolerance, Fasting hyperinsulinemia, Increased body mass index, Polyphagia ORPHA:300373
Pediatric-Onset Graves Disease
Polydipsia, Polyphagia, Failure to thrive ORPHA:525731
Sim1-Related Prader-Willi-Like Syndrome
Polyphagia, Failure to thrive, Abdominal obesity, Type II diabetes mellitus, Obesity ORPHA:398079
Paternal Uniparental Disomy Of Chromosome 1
Polyphagia, Obesity ORPHA:251004
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Polyphagia, Small for gestational age, Bulimia, Failure to thrive, Diabetes mellitus, Obesity ORPHA:98754
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Polyphagia, Small for gestational age, Bulimia, Failure to thrive, Diabetes mellitus, Obesity ORPHA:98793
Magel2-Related Prader-Willi-Like Syndrome
Abdominal obesity, Polyphagia, Increased body weight, Failure to thrive, Type II diabetes mellitus ORPHA:398069
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Polyphagia, Small for gestational age, Bulimia, Failure to thrive, Diabetes mellitus, Obesity ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Polyphagia, Small for gestational age, Bulimia, Failure to thrive, Diabetes mellitus, Obesity ORPHA:177901
Prader-Willi Syndrome
Hyperinsulinemia, Polyphagia, Failure to thrive in infancy, Type II diabetes mellitus, Abdominal ... OMIM:176270
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Mental Retardation, Autosomal Dominant 1
Polyphagia OMIM:156200
Prader-Willi-Like Syndrome
Polyphagia, Small for gestational age, Bulimia, Failure to thrive, Diabetes mellitus, Obesity ORPHA:398073
Angelman Syndrome
Dysphagia, Polyphagia, Obesity ORPHA:72
Craniopharyngioma
Polyphagia, Type II diabetes mellitus, Obesity ORPHA:54595
Lipodystrophy, Congenital Generalized, Type 1
Hypertriglyceridemia, Insulin-resistant diabetes mellitus at puberty, Hyperinsulinemia, Polyphagia OMIM:608594
Prader-Willi Syndrome
Diabetes mellitus, Polyphagia, Failure to thrive, Abdominal obesity ORPHA:739
Gangliocytoma
Polyphagia ORPHA:251937
Lipodystrophy, Congenital Generalized, Type 2
Hypertriglyceridemia, Insulin-resistant diabetes mellitus at puberty, Hyperinsulinemia, Polyphagia OMIM:269700
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Polyphagia OMIM:607485
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Polyphagia ORPHA:251028
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polyphagia, Hyperglycemia, Polydipsia, Hyperlipidemia, Obesity ORPHA:293987
7Q11.23 Microduplication Syndrome
Polyphagia, Obesity ORPHA:96121
Pseudohypoparathyroidism Type 1C
Polyphagia, Obesity ORPHA:79444
Adnp Syndrome
Truncal obesity, Polyphagia, Oral-pharyngeal dysphagia ORPHA:404448
Mody
Abnormal oral glucose tolerance, Hyperinsulinemic hypoglycemia, Neonatal hypoglycemia, Glucose in... ORPHA:552
Pseudohypoparathyroidism Type 1A
Polyphagia, Obesity ORPHA:79443
Early-Onset Schizophrenia
Polyphagia ORPHA:96369
1P36 Deletion Syndrome
Dysphagia, Polyphagia, Failure to thrive, Obesity ORPHA:1606
Chromosome 1P36 Deletion Syndrome
Dysphagia, Polyphagia, Obesity OMIM:607872
Alström Syndrome
Hyperinsulinemia, Polyphagia, Insulin resistance, Hypertriglyceridemia, Truncal obesity, Type II ... ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gfral

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gfral.

No publications found that use IMPC mice or data for Gfral.

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MGI Allele Allele Type Produced
Gfraltm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gfraltm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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