Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
GDNF family receptor alpha like
Synonyms:
GRAL

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gfral mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gfral by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Obesity Due To Melanocortin 4 Receptor Deficiency
Obesity, Hyperinsulinemia, Type II diabetes mellitus, Polyphagia, Childhood-onset truncal obesity... ORPHA:71529
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Aggressive behavior, Obesity, Polyphagia, Hyperinsulinemia ORPHA:329249
Body Mass Index Quantitative Trait Locus 19
Insulin resistance, Obesity, Hyperinsulinemia, Hyperlipidemia, Polyphagia, Hypertriglyceridemia OMIM:617885
Body Mass Index Quantitative Trait Locus 20
Polyphagia, Obesity, Hyperinsulinemia OMIM:618406
Obesity And Hypopigmentation
Polyphagia, Obesity, Hyperinsulinemia OMIM:620195
Obesity Due To Sim1 Deficiency
Obesity, Glucose intolerance, Hyperinsulinemia, Polyphagia, Attention deficit hyperactivity disorder ORPHA:369873
Hyperinsulinism Due To Hnf1A Deficiency
Maturity-onset diabetes of the young, Large for gestational age, Hyperinsulinemia, Hypoketotic hy... ORPHA:324575
Obesity, Hyperphagia, And Developmental Delay
Polyphagia, Obesity, Motor stereotypy OMIM:613886
Type 1 Diabetes Mellitus
Hyperglycemia, Polydipsia, Diabetes mellitus, Polyphagia OMIM:222100
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Type I diabetes mellitus, Large for gestational age, Hyperinsulinemia, Hypoketotic hypoglycemia, ... ORPHA:276580
Leptin Receptor Deficiency
Obesity, Abnormal eating behavior, Aggressive behavior, Polyphagia, Diabetes mellitus OMIM:614963
Obesity Due To Prohormone Convertase I Deficiency
Failure to thrive, Obesity, Hyperinsulinemia, Polyphagia, Childhood-onset truncal obesity, Hypogl... ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Failure to thrive, Obesity, Hyperinsulinemia, Polyphagia, Childhood-onset truncal obesity, Hypogl... ORPHA:71526
Bardet-Biedl Syndrome 22
Polyphagia, Obesity, Large for gestational age OMIM:617119
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Type I diabetes mellitus, Large for gestational age, Hypoketotic hypoglycemia, Hyperinsulinemia, ... ORPHA:276575
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Hyperinsulinism Due To Ucp2 Deficiency
Recurrent hypoglycemia, Large for gestational age, Hypoketotic hypoglycemia, Reactive hypoglycemi... ORPHA:276556
Intellectual Developmental Disorder, Autosomal Dominant 39
Polyphagia, Obesity, Aggressive behavior, Self-mutilation OMIM:616521
Pick Disease Of Brain
Polyphagia, Inappropriate laughter, Motor stereotypy, Disinhibition OMIM:172700
Renal Glucosuria
Polyphagia, Polydipsia, Glycosuria OMIM:233100
Leptin Deficiency Or Dysfunction
Polyphagia, Obesity OMIM:614962
Hypermetabolism Due To Uncoupled Mitochondrial Oxidative Phosphorylation 2
Polyphagia, Failure to thrive, Decreased body weight OMIM:620085
Temple Syndrome
Recurrent hypoglycemia, Obesity, Type II diabetes mellitus, Polyphagia, Small for gestational age ORPHA:254516
Hypotonia-Cystinuria Syndrome
Polyphagia, Failure to thrive ORPHA:163690
14Q11.2 Microduplication Syndrome
Attention deficit hyperactivity disorder, Polyphagia, Obesity, Aggressive behavior ORPHA:261229
Obesity Due To Congenital Leptin Deficiency
Insulin-resistant diabetes mellitus, Obesity, Hyperinsulinemia, Polyphagia, Hypertriglyceridemia ORPHA:66628
Frontotemporal Dementia
Polyphagia, Inappropriate laughter, Disinhibition OMIM:600274
Obesity Due To Leptin Receptor Gene Deficiency
Insulin-resistant diabetes mellitus, Obesity, Hyperinsulinemia, Polyphagia, Hypertriglyceridemia ORPHA:179494
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Hypoglycemic seizures, Decreased circulating cortisol level, Obesity, Polyphagia OMIM:609734
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Polyphagia, Obesity, Inappropriate laughter, Hyperactivity ORPHA:411515
Prader-Willi Syndrome Due To Imprinting Mutation
Polyphagia, Obesity ORPHA:177910
Huntington Disease
Decreased body mass index, Oral-pharyngeal dysphagia, Disinhibition, Polyphagia, Addictive alcoho... ORPHA:399
Bardet-Biedl Syndrome 9
Polydipsia, Hyperglycemia, Obesity, Polyphagia, Truncal obesity OMIM:615986
Kleine-Levin Syndrome
Polydipsia, Abnormal eating behavior, Sweet craving, Polyphagia, Repetitive compulsive behavior, ... ORPHA:33543
6Q16 Microdeletion Syndrome
Abnormal temper tantrums, Polyphagia, Obesity ORPHA:171829
Insulinoma
Fasting hyperinsulinemia, Recurrent hypoglycemia, Hyperinsulinemia, Reactive hypoglycemia, Increa... ORPHA:97279
Graves Disease
Polyphagia, Weight loss, Hyperactivity OMIM:275000
Intellectual Developmental Disorder, Autosomal Dominant 72
Attention deficit hyperactivity disorder, Polyphagia, Obesity, Overfriendliness OMIM:620439
Joubert Syndrome 10
Polyphagia, Obesity, Frequent temper tantrums, Decreased body weight OMIM:300804
2Q23.1 Microdeletion Syndrome
Self-injurious behavior, Polyphagia, Motor stereotypy, Hyperactivity, Paroxysmal bursts of laughter ORPHA:228402
Hypotonia-Cystinuria Syndrome
Polyphagia, Neonatal hypoglycemia, Failure to thrive OMIM:606407
Coronary Artery Disease, Autosomal Dominant 2
Glucose intolerance, Type II diabetes mellitus, Impaired glucose tolerance, Hypertriglyceridemia OMIM:610947
Schaaf-Yang Syndrome
Failure to thrive in infancy, Obesity, Polyphagia, Skin-picking, Impulsivity OMIM:615547
Secondary Short Bowel Syndrome
Steatorrhea, Polyphagia, Weight loss, Failure to thrive ORPHA:95427
Man1B1-Cdg
Polyphagia, Truncal obesity ORPHA:397941
Chromosome 22Q13 Duplication Syndrome
Polyphagia, Attention deficit hyperactivity disorder, Impulsivity OMIM:615538
Luscan-Lumish Syndrome
Polyphagia, Obesity, Aggressive behavior OMIM:616831
Cebalid Syndrome
Polyphagia OMIM:618774
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Disinhibition, Polyphagia, Repetitive compulsive behavior, Agitation, Hypersexuality OMIM:607485
Wagro Syndrome
Obesity, Polyphagia, Aggressive behavior, Compulsive behaviors, Agitation OMIM:612469
Trisomy 18P
Polyphagia, Attention deficit hyperactivity disorder ORPHA:1715
Hypertriglyceridemia 1
Glucose intolerance, Hypertriglyceridemia OMIM:145750
Angelman Syndrome
Self-injurious behavior, Obesity, Inappropriate laughter, Recurrent hand flapping, Polyphagia, Ag... ORPHA:72
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Obsessive... ORPHA:98793
Prader-Willi Syndrome
Self-injurious behavior, Class III obesity, Failure to thrive in infancy, Obesity, Hyperinsulinem... OMIM:176270
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Obsessive... ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Obsessive... ORPHA:177901
Sim1-Related Prader-Willi-Like Syndrome
Abnormal temper tantrums, Failure to thrive, Obesity, Type II diabetes mellitus, Polyphagia, Skin... ORPHA:398079
Pediatric-Onset Graves Disease
Polyphagia, Polydipsia, Failure to thrive, Hyperactivity ORPHA:525731
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Self-injurious behavior, Abnormal temper tantrums, Failure to thrive, Bulimia, Obesity, Polyphagi... ORPHA:98754
Magel2-Related Prader-Willi-Like Syndrome
Abnormal temper tantrums, Failure to thrive, Type II diabetes mellitus, Increased body weight, Po... ORPHA:398069
X-Linked Acrogigantism
Abnormal oral glucose tolerance, Polyphagia, Fasting hyperinsulinemia, Increased body mass index ORPHA:300373
Intellectual Developmental Disorder, Autosomal Dominant 1
Self-injurious behavior, Bruxism, Inappropriate laughter, Recurrent hand flapping, Polyphagia, Ag... OMIM:156200
Paternal Uniparental Disomy Of Chromosome 1
Polyphagia, Obesity ORPHA:251004
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Polyphagia, Restlessness, Aggressive behavior, Self-mutilation ORPHA:251028
Lipodystrophy, Congenital Generalized, Type 1
Hyperinsulinemia, Polyphagia, Hypertriglyceridemia, Diabetes mellitus, Insulin-resistant diabetes... OMIM:608594
Prader-Willi Syndrome
Failure to thrive, Polyphagia, Attention deficit hyperactivity disorder, Abdominal obesity, Diabe... ORPHA:739
Craniopharyngioma
Polyphagia, Obesity, Type II diabetes mellitus ORPHA:54595
Lipodystrophy, Congenital Generalized, Type 2
Hyperinsulinemia, Type II diabetes mellitus, Polyphagia, Hypertriglyceridemia, Insulin-resistant ... OMIM:269700
Adnp Syndrome
Abnormal temper tantrums, Oral-pharyngeal dysphagia, Polyphagia, Attention deficit hyperactivity ... ORPHA:404448
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Self-injurious behavior, Polydipsia, Hyperglycemia, Obesity, Hyperlipidemia, Polyphagia, Aggressi... ORPHA:293987
7Q11.23 Microduplication Syndrome
Self-injurious behavior, Obesity, Aggressive behavior, Polyphagia, Hyperactivity, Collectionism, ... ORPHA:96121
Gangliocytoma
Polyphagia ORPHA:251937
Helsmoortel-Van Der Aa Syndrome
Failure to thrive, Bruxism, Obesity, Polyphagia, Attention deficit hyperactivity disorder, Dyspha... OMIM:615873
Mody
Glycosuria, Insulin-resistant diabetes mellitus, Hyperglycemia, Obesity, Large for gestational ag... ORPHA:552
Weaver Syndrome
Polyphagia OMIM:277590
Pseudohypoparathyroidism Type 1C
Polyphagia, Obesity ORPHA:79444
Pseudohypoparathyroidism Type 1A
Polyphagia, Obesity ORPHA:79443
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Self-injurious behavior, Fixated interests, Hair-pulling, Polyphagia, Attention deficit hyperacti... OMIM:620330
1P36 Deletion Syndrome
Self-injurious behavior, Failure to thrive, Obesity, Motor stereotypy, Polyphagia, Dysphagia ORPHA:1606
Chromosome 1P36 Deletion Syndrome, Distal
Obesity, Oppositional defiant disorder, Self-mutilation, Aggressive behavior, Polyphagia, Dysphagia OMIM:607872
Alström Syndrome
Insulin resistance, Obesity, Hyperinsulinemia, Hyperlipidemia, Type II diabetes mellitus, Polypha... ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gfral

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gfral.

No publications found that use IMPC mice or data for Gfral.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Gfraltm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Gfraltm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Gfraltm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gfraltm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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