Gene Summary

solute carrier family 15, member 5

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
enlarged gallbladder Slc15a5em1(IMPC)H HOM Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Slc15a5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Slc15a5 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Cholangiocarcinoma, Susceptibility To
Cholangiocarcinoma OMIM:615619
Gallbladder Disease 4
Cholelithiasis OMIM:611465
Gallbladder Disease 1
Hepatic fibrosis, Cholesterol gallstones, Jaundice, Elevated hepatic transaminase, Portal inflamm... OMIM:600803
Decreased liver function, Cholestasis, Cholelithiasis OMIM:614156
Biliary Atresia, Extrahepatic
Atretic gallbladder, Cirrhosis, Extrahepatic biliary duct atresia, Jaundice, Elevated hepatic tra... OMIM:210500
Protoporphyria, Erythropoietic, X-Linked
Elevated hepatic transaminase, Cholelithiasis OMIM:300752
Anemia, Congenital Dyserythropoietic, Type Ii
Splenomegaly, Jaundice, Cholelithiasis OMIM:224100
Cholestasis, Benign Recurrent Intrahepatic, 2
Jaundice, Cholelithiasis, Hepatomegaly, Intrahepatic cholestasis OMIM:605479
Benign Recurrent Intrahepatic Cholestasis
Cholelithiasis, Cirrhosis, Jaundice, Hepatocellular carcinoma, Elevated hepatic transaminase, Ach... ORPHA:65682
Biliary Cirrhosis, Primary, 1
Biliary cirrhosis OMIM:109720
Low Phospholipid-Associated Cholelithiasis
Biliary cirrhosis, Liver abscess, Neoplasm of the liver, Sclerosing cholangitis, Hepatocellular c... ORPHA:69663
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Splenomegaly, Jaundice, Cholecystitis, Pigment gallstones, Cholelithiasis OMIM:613470
Splenomegaly, Hypersplenism, Jaundice, Cholelithiasis ORPHA:846
Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency
Splenomegaly, Jaundice, Cholelithiasis, Cholecystitis OMIM:235700
Sclerosing Cholangitis, Neonatal
Biliary cirrhosis, Cirrhosis, Hepatic failure, Sclerosing cholangitis, Jaundice, Acholic stools, ... OMIM:617394
Spherocytosis, Type 1
Splenomegaly, Jaundice, Cholelithiasis OMIM:182900
North American Indian Childhood Cirrhosis
Portal hypertension, Prolonged neonatal jaundice, Biliary cirrhosis OMIM:604901
Autosomal Erythropoietic Protoporphyria
Decreased liver function, Cirrhosis, Cholelithiasis ORPHA:79278
Gcgr-Related Hyperglucagonemia
Neoplasm of the pancreas, Abnormal biliary tract morphology, Cholelithiasis ORPHA:438274
Cholestasis, Progressive Familial Intrahepatic, 1
Cirrhosis, Jaundice, Hepatomegaly, Cholelithiasis, Intrahepatic cholestasis with episodic jaundic... OMIM:211600
Protoporphyria, Erythropoietic, 1
Hepatic failure, Cholelithiasis OMIM:177000
Pancreatic Colipase Deficiency
Exocrine pancreatic insufficiency, Cholelithiasis ORPHA:309108
Caroli Disease
Hepatic fibrosis, Biliary cirrhosis, Elevated circulating alanine aminotransferase concentration,... ORPHA:53035
Pyruvate Kinase Deficiency Of Red Cells
Splenomegaly, Jaundice, Cholecystitis, Hepatomegaly, Cholelithiasis OMIM:266200
Parenteral Nutrition-Associated Cholestasis
Hepatic fibrosis, Biliary hyperplasia, Cirrhosis, Hepatic failure, Jaundice, Elevated hepatic tra... ORPHA:567983
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Splenomegaly, Hepatitis, Jaundice, Hepatomegaly, Cholelithiasis OMIM:194380
Mirizzi Syndrome
Cholesterol gallstones, Jaundice, Elevated hepatic transaminase, Cholelithiasis, Abnormality of t... ORPHA:521219
Glycogen Storage Disease Vii
Jaundice, Cholelithiasis OMIM:232800
Hepatitis, Splenomegaly, Hepatomegaly, Cholelithiasis ORPHA:848
Isolated Biliary Atresia
Atretic gallbladder, Cirrhosis, Periportal fibrosis, Jaundice, Elevated hepatic transaminase, Hyp... ORPHA:30391
Martinez-Frias Syndrome
Pancreatic hypoplasia, Annular pancreas, Hypoplasia of the gallbladder, Extrahepatic biliary duct... OMIM:601346
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Hepatitis, Cholesterol gallstones, Hepatic steatosis, Cholestasis, Acute hepatic steatosis, Macro... ORPHA:209902
Mitchell-Riley Syndrome
Pancreatic hypoplasia, Absent gallbladder, Biliary atresia, Acholic stools, Cholestasis, Annular ... OMIM:615710
Beta-Thalassemia Intermedia
Cholelithiasis, Cirrhosis, Abnormality of the liver, Jaundice, Hepatocellular carcinoma, Hepatosp... ORPHA:231222
Congenital Bile Acid Synthesis Defect Type 4
Giant cell hepatitis, Elevated hepatic transaminase, Cholelithiasis, Cholestatic liver disease ORPHA:79095
Intermittent jaundice, Increased circulating prolactin concentration, Extrahepatic cholestasis, P... ORPHA:97278
Sickle Cell Disease
Splenic infarction, Jaundice, Hepatomegaly, Cholelithiasis, Cardiomegaly, Splenomegaly OMIM:603903
Elevated hepatic transaminase, Cholelithiasis, Hepatomegaly, Hepatosplenomegaly ORPHA:3166
Primary Sclerosing Cholangitis
Hepatic fibrosis, Cirrhosis, Hepatitis, Jaundice, Pancreatitis, Cholangiocarcinoma, Elevated hepa... ORPHA:171
Myotonic Dystrophy 1
Testicular atrophy, Cholelithiasis OMIM:160900
Meckel Syndrome, Type 6
Absent gallbladder, Hepatic fibrosis, Bile duct proliferation, Hepatic cysts, Cystic liver disease OMIM:612284
Intermittent jaundice, Increased circulating prolactin concentration, Extrahepatic cholestasis, P... ORPHA:97261
Glycogen Storage Disease Xii
Elevated circulating alanine aminotransferase concentration, Jaundice, Cholecystitis, Hepatomegal... OMIM:611881
Sickle Cell Anemia
Abnormality of the spleen, Cholestasis, Pigment gallstones ORPHA:232
Hereditary Elliptocytosis
Splenomegaly, Jaundice, Prolonged neonatal jaundice, Cholelithiasis ORPHA:288
Peroxisome Biogenesis Disorder 12A (Zellweger)
Hepatic failure, Elevated hepatic transaminase, Cholelithiasis OMIM:614886
Hereditary Spherocytosis
Jaundice, Splenomegaly, Hepatomegaly, Cholelithiasis ORPHA:822
Triosephosphate Isomerase Deficiency
Jaundice, Cholecystitis, Cholelithiasis, Prolonged neonatal jaundice, Splenomegaly OMIM:615512
Cimdag Syndrome
Microvesicular hepatic steatosis, Cholelithiasis, Hepatomegaly OMIM:619273
Generalized Pseudohypoaldosteronism Type 1
Cholelithiasis ORPHA:171876
Dehydrated Hereditary Stomatocytosis
Intermittent jaundice, Splenomegaly, Portal vein thrombosis, Cholelithiasis ORPHA:3202
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia
Cholelithiasis, Asplenia, Hypoparathyroidism, Chronic active hepatitis OMIM:240300
Intellectual Developmental Disorder, X-Linked, Syndromic, Claes-Jensen Type
Decreased testicular size, Cholelithiasis, Cryptorchidism OMIM:300534
Distal Trisomy 5Q
Aplasia/Hypoplasia of the gallbladder, Cryptorchidism ORPHA:96097
Metachromatic Leukodystrophy
Neoplasm of the gallbladder, Abnormal gallbladder morphology, Hemobilia ORPHA:512
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Cholelithiasis OMIM:618775
Hereditary Hemorrhagic Telangiectasia
Hepatic failure, Cirrhosis, Cholecystitis, Portal hypertension, Cholelithiasis ORPHA:774
Trichohepatoneurodevelopmental Syndrome
Recurrent pancreatitis, Decreased liver function, Hepatomegaly, Cholelithiasis, Exocrine pancreat... OMIM:618268
Porphyria, Congenital Erythropoietic
Jaundice, Splenomegaly, Hepatomegaly, Cholelithiasis OMIM:263700
8P Inverted Duplication/Deletion Syndrome
Aplasia/Hypoplasia of the gallbladder, Cryptorchidism ORPHA:96092
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies
Cholecystitis, Cholelithiasis, Hepatomegaly, Hepatosplenomegaly OMIM:301066
Basel-Vanagaite-Smirin-Yosef Syndrome
Cholelithiasis ORPHA:464738
Congenital Alveolar Capillary Dysplasia
Absent gallbladder, Asplenia, Annular pancreas ORPHA:210122
Cerebrotendinous Xanthomatosis
Cholelithiasis OMIM:213700
Pentalogy Of Cantrell
Absent gallbladder, Polysplenia ORPHA:1335
Pancreatic Agenesis-Holoprosencephaly Syndrome
Absent gallbladder, Pancreatic aplasia ORPHA:556955
Intrahepatic cholestasis, Elevated hepatic transaminase, Bilobate gallbladder, Hepatosplenomegaly OMIM:607330
Bohring-Opitz Syndrome
Cardiomegaly, Cholelithiasis, Annular pancreas ORPHA:97297
Chronic Visceral Acid Sphingomyelinase Deficiency
Cirrhosis, Hepatic failure, Hypersplenism, Neoplasm of the liver, Hepatomegaly, Cholelithiasis, D... ORPHA:77293
Trisomy 8P
Annular pancreas, Aplasia/Hypoplasia of the gallbladder, Cryptorchidism ORPHA:264450
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Pancreatic hypoplasia, Biliary hyperplasia, Hepatomegaly, Cryptorchidism, Cholelithiasis ORPHA:83617
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Absent gallbladder, Elevated circulating alanine aminotransferase concentration, Pancreatic aplas... OMIM:618500
Craniofacioskeletal Syndrome
Absent gallbladder, Cryptorchidism OMIM:300712
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Hepatic fibrosis, Hepatosplenomegaly, Cholelithiasis, Abnormality of the spleen, Splenomegaly ORPHA:2072
Steinfeld Syndrome
Absent gallbladder OMIM:184705
22Q11.2 Deletion Syndrome
Splenomegaly, Hypoplasia of the thymus, Hypoparathyroidism, Cryptorchidism, Cholelithiasis ORPHA:567
Cerebrotendinous Xanthomatosis
Prolonged neonatal jaundice, Cholelithiasis ORPHA:909
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Pancreatic hypoplasia, Biliary atresia, Aplasia/Hypoplasia of the gallbladder, Pancreatic aplasia... ORPHA:2255
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome
Absent gallbladder, Cryptorchidism ORPHA:163979
Steinert Myotonic Dystrophy
Decreased response to growth hormone stimulation test, Elevated hepatic transaminase, Secondary h... ORPHA:273
Short-Rib Thoracic Dysplasia 20 With Polydactyly
Absent gallbladder OMIM:617925
Trisomy 10P
Absent gallbladder ORPHA:171929
Digeorge Syndrome
Hypoplasia of the thymus, Hydrocele testis, Hepatic steatosis, Parathyroid hypoplasia, Parathyroi... OMIM:188400
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Absent gallbladder ORPHA:3186
Zttk Syndrome
Absent gallbladder OMIM:617140
Heart Defects, Congenital, And Other Congenital Anomalies
Absent gallbladder, Biliary atresia, Pancreatic hypoplasia OMIM:600001
Tetrasomy 9P
Absent gallbladder, Jaundice, Biliary atresia, Cryptorchidism ORPHA:3310
Williams Syndrome
Cardiomegaly, Polycystic ovaries, Cholelithiasis, Cryptorchidism ORPHA:904
Ring Chromosome 13 Syndrome
Hypoplasia of the gallbladder ORPHA:96176
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Absent gallbladder ORPHA:500150
Peters-Plus Syndrome
Bilobate gallbladder, Biliary tract abnormality, Cryptorchidism OMIM:261540


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Slc15a5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc15a5.

No publications found that use IMPC mice or data for Slc15a5.

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MGI Allele Allele Type Produced
Slc15a5em3(IMPC)H Exon Deletion Mice
Slc15a5em1(IMPC)H Exon Deletion Mice
Slc15a5tm41651(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Slc15a5tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Slc15a5em2(IMPC)H Exon Deletion Mice

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