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Gene: Piezo1 MGI:3603204

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Gene Summary

Name:
piezo-type mechanosensitive ion channel component 1
Synonyms:
Fam38a,  Piezo1

Order Alleles

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal urinary bladder morphology Piezo1tm1b(KOMP)Wtsi HET Early adult 0.00
embryonic growth retardation Piezo1tm1b(KOMP)Wtsi HOM E9.5 0.00
preweaning lethality, complete penetrance Piezo1tm1b(KOMP)Wtsi HOM   Early adult 0.00
abnormal embryo size Piezo1tm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal limb bud morphology Piezo1tm1b(KOMP)Wtsi HOM E12.5 0.00
decreased locomotor activity Piezo1tm1b(KOMP)Wtsi HET Early adult 3.37×10-06
pallor Piezo1tm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal placenta size Piezo1tm1b(KOMP)Wtsi HET E12.5 0.00
abnormal embryo size Piezo1tm1b(KOMP)Wtsi HET E12.5 0.00
increased circulating alanine transaminase level Piezo1tm1b(KOMP)Wtsi HET Early adult 2.38×10-29
pale yolk sac Piezo1tm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal placenta size Piezo1tm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal embryo size Piezo1tm1b(KOMP)Wtsi HOM E9.5 0.00

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

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OPT E9.5

Embryo reconstruction

8 Images

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Gross Morphology Embryo E9.5

Images

4 Images

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Human diseases caused by Piezo1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Piezo1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Lymphatic Malformation 6
Genital edema, Short stature, Nonimmune hydrops fetalis, Polyhydramnios, Edema, Facial edema, Per... OMIM:616843
Dehydrated Hereditary Stomatocytosis
Increased circulating lactate dehydrogenase concentration, Pulmonary venous hypertension, Intermi... ORPHA:3202
Milroy Disease
Predominantly lower limb lymphedema, Pedal edema, Lymphedema ORPHA:79452

The table below shows human diseases predicted to be associated to Piezo1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pentosuria
Abnormal urine carbohydrate level, Abnormal circulating carbohydrate concentration, Abnormality o... ORPHA:2843
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Polyhydramnios, Pericardial effusion, Stillbirth, Pleural effusion, Ge... OMIM:618773
Congenital Heart Block
Pericardial effusion, Patent ductus arteriosus, Hydrops fetalis, Peripheral edema, Endocardial fi... ORPHA:60041
Nephrosialidosis
Pericardial effusion, Ascites OMIM:256150
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Combined Oxidative Phosphorylation Deficiency 10
Cardiomegaly, Pericardial effusion, Pleural effusion, Intrauterine growth retardation, Hypertroph... OMIM:614702
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Primary Effusion Lymphoma
Pericardial effusion, Pleural effusion ORPHA:48686
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Peripheral Cone Dystrophy
Pallor OMIM:609021
Choanal Atresia And Lymphedema
Pericardial effusion, Lymphedema OMIM:613611
Cantu Syndrome
Bicuspid aortic valve, Cardiomegaly, Pericardial effusion, Lymphedema, Patent ductus arteriosus, ... OMIM:239850
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Short stature, Pallor ORPHA:2786
Congenital Pulmonary Lymphangiectasia
Hydrops fetalis, Chylopericardium, Growth delay, Pulmonic stenosis, Pleural effusion, Ascites ORPHA:2414
Lymphatic Malformation 7
Nonimmune hydrops fetalis, Edema, Lymphedema, Facial edema, Pericardial effusion, Increased nucha... OMIM:617300
Breath-Holding Spells
Pallor OMIM:607578
Hydrops Fetalis
Nonimmune hydrops fetalis, Polyhydramnios, Lymphedema, Pericardial effusion, Abnormal heart morph... ORPHA:1041
Dermatitis, Atopic
Dry skin, Pallor, Facial erythema OMIM:603165
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Optic Atrophy 1
Pallor OMIM:165500
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Meckel Syndrome, Type 8
Pericardial effusion, Occipital encephalocele, Encephalocele OMIM:613885
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Congenital Disorder Of Glycosylation, Type Il
Pericardial effusion, Ascites, Abnormal cardiac septum morphology, Edema OMIM:608776
Anemia, Congenital Dyserythropoietic, Type Ib
Growth delay, Syndactyly, Short stature, Pallor OMIM:615631
Hypertelorism And Other Facial Dysmorphism, Brachydactyly, Genital Abnormalities, Mental Retardation, And Recurrent Inflammatory Episodes
Pericardial effusion OMIM:614684
Craniofaciofrontodigital Syndrome
Bicuspid aortic valve, Ventricular septal defect, Polyhydramnios, Edema, Cardiomegaly, Pericardia... ORPHA:363705
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Growth delay, Pallor OMIM:613561
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor OMIM:612989
Neurodevelopmental Disorder With Short Stature, Prominent Forehead, And Feeding Difficulties
Short stature, Polyhydramnios, Pericardial effusion, Multiple muscular ventricular septal defects... OMIM:620070
Hemoglobin D Disease
Pallor ORPHA:90039
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Cardiomyopathy, Familial Hypertrophic, 4
Ventricular hypertrophy, Cardiomegaly, Pericardial effusion, Muscular ventricular septal defect, ... OMIM:115197
Congenital Tricuspid Valve Dysplasia
Cardiomegaly, Pericardial effusion, Anomalous pulmonary venous return, Abnormal tricuspid valve a... ORPHA:555874
Cyclic Vomiting Syndrome
Growth delay, Pallor OMIM:500007
Thiamine-Responsive Megaloblastic Anemia Syndrome
Short stature, Pallor ORPHA:49827
Retinitis Pigmentosa 51
Polydactyly, Pallor OMIM:613464
Congenital Enterovirus Infection
Fetal ascites, Polyhydramnios, Pericardial effusion, Myocarditis, Hydrops fetalis, Cardiomyopathy... ORPHA:292
Hypocomplementemic Urticarial Vasculitis
Abnormal heart valve morphology, Pericardial effusion, Angioedema, Pleural effusion, Ascites ORPHA:36412
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor ORPHA:276608
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Pericardial lymphangiectasia, Ventricular septal defect, Nonimmune hydrops fetalis, Mild postnata... OMIM:235510
Pulmonary Non-Tuberculous Mycobacterial Infection
Pericardial effusion, Pleural effusion ORPHA:411703
Primary Intestinal Lymphangiectasia
Edema, Pericardial effusion, Growth delay, Pleural effusion, Ascites, Generalized edema ORPHA:90362
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Nonimmune hydrops fetalis, Pericardial effusion, Endocardial fibroelastosis, Restrictive cardiomy... OMIM:619313
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Pericardial effusion, Intrauterine growth retardation, Hypertrophic cardiomyopathy, Ventricular s... OMIM:618775
Drug-Induced Lupus Erythematosus
Pericardial effusion, Pericarditis ORPHA:231111
Aicardi-Goutieres Syndrome 9
Pericarditis, Edema, Pericardial effusion, Left ventricular hypertrophy, Intrauterine growth reta... OMIM:619487
Myopathic Ehlers-Danlos Syndrome
Tapered finger, Talipes equinovarus, Pallor, Congenital finger flexion contractures, Adducted thumb ORPHA:536516
Fanconi Anemia, Complementation Group I
Short stature, Absent thumb, Short thumb, Hypoplasia of the radius, Pallor, Intrauterine growth r... OMIM:609053
Gaucher Disease Type 1
Pericardial effusion, Pedal edema, Growth delay, Delayed puberty, Abnormal myocardium morphology,... ORPHA:77259
Myelofibrosis
Pallor, Purpura OMIM:254450
Alkuraya-Kucinskas Syndrome
Pericardial effusion, Pleural effusion, Edema OMIM:617822
Evans Syndrome
Pallor, Petechiae ORPHA:1959
Neurodegeneration, Childhood-Onset, With Multisystem Involvement Due To Mitochondrial Dysfunction
Pericardial effusion, Cardiomyopathy OMIM:620089
Acute Interstitial Pneumonia
Pericardial effusion, Pleural effusion, Peripheral edema ORPHA:79126
Hyperinsulinism Due To Ucp2 Deficiency
Pallor ORPHA:276556
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Short stature, Pallor OMIM:611590
Pediatric Systemic Lupus Erythematosus
Pericardial effusion, Pleural effusion, Ascites, Edema ORPHA:93552
Glycogen Storage Disease Of Heart, Lethal Congenital
Cardiomegaly, Pericardial effusion, Increased myocardial glycogen content, Biventricular hypertro... OMIM:261740
Cardiac-Urogenital Syndrome
Cor triatrium sinister, Ventricular septal defect, Dextrocardia, Coronary sinus enlargement, Peri... OMIM:618280
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Pallor ORPHA:276575
Irida Syndrome
Pallor ORPHA:209981
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Pallor OMIM:266200
Cardiomyopathy, Dilated, 1A
Pericardial effusion, Dilated cardiomyopathy OMIM:115200
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Pallor ORPHA:276580
Lymphoproliferative Syndrome 1
Pericardial effusion, Pleural effusion OMIM:613011
Hyperinsulinism Due To Hnf1A Deficiency
Pallor ORPHA:324575
Anemia, Hypochromic Microcytic, With Iron Overload 2
Growth delay, Pallor OMIM:615234
Dravet Syndrome
Pallor, Tibial torsion ORPHA:33069
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Leishmaniasis
Pallor, Skin ulcer ORPHA:507
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Ventricular septal defect, Pericardial effusion, Dilated cardiomyopathy, Atrial septal defect, Pa... ORPHA:26793
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Growth delay, Pallor, Delayed puberty OMIM:600462
Congenital Disorder Of Glycosylation, Type Ia
Pericarditis, Nonimmune hydrops fetalis, Edema, Pericardial effusion, Cardiomyopathy OMIM:212065
Hb Bart'S Hydrops Fetalis
Pallor ORPHA:163596
Aymé-Gripp Syndrome
Pericarditis, Short stature, Pericardial effusion, Postnatal growth retardation, Patent ductus ar... ORPHA:1272
Poems Syndrome
Pericardial effusion, Pleural effusion, Ascites, Edema ORPHA:2905
Primary Myelofibrosis
Ecchymosis, Pallor, Petechiae, Purpura ORPHA:824
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema ORPHA:439218
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Gaucher Disease Type 3
Mitral valve calcification, Abnormal heart valve morphology, Pericardial effusion, Aortic valve c... ORPHA:77261
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
Pericardial effusion, Abnormal myocardium morphology, Dilated cardiomyopathy ORPHA:300751
Diarrhea 10, Protein-Losing Enteropathy Type
Polyhydramnios, Pericardial effusion, Anasarca, Pleural effusion, Ascites OMIM:618183
Pulmonary Capillary Hemangiomatosis
Pericardial effusion, Pleural effusion, Pedal edema, Pulmonary edema ORPHA:199241
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Retinitis Pigmentosa 75
Pallor OMIM:617023
Myhre Syndrome
Ventricular septal defect, Short stature, Pericardial effusion, Patent ductus arteriosus, Birth l... OMIM:139210
Cold Agglutinin Disease
Pallor ORPHA:56425
Q Fever
Pericarditis, Abnormal heart valve morphology, Pericardial effusion, Myocarditis, Endocarditis, P... ORPHA:781
Alg9-Cdg
Ventricular septal defect, Rhizomelia, Pericardial effusion, Hydrops fetalis, Abnormal heart morp... ORPHA:79328
Elliptocytosis 1
Pallor OMIM:611804
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Classical-Like Ehlers-Danlos Syndrome Type 2
Pericardial effusion, Umbilical hernia, Mitral valve prolapse ORPHA:536532
Deafness-Lymphedema-Leukemia Syndrome
Pallor ORPHA:3226
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor OMIM:246450
Congenital Dyserythropoietic Anemia Type Iii
Short stature, Pallor ORPHA:98870
Hennekam Syndrome
Mild postnatal growth retardation, Lymphedema, Pericardial effusion, Hydrops fetalis, Chylothorax... ORPHA:2136
Senior-Loken Syndrome 8
Polydactyly, Pallor OMIM:616307
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Myopathy, Mitochondrial, And Ataxia
Growth delay, Short stature, Pallor OMIM:617675
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Kaposiform Lymphangiomatosis
Pericardial effusion, Pleural effusion ORPHA:464329
Tay-Sachs Disease
Pallor OMIM:272800
Rheumatic Fever
Erythema, Pallor ORPHA:3099
Idiopathic Pulmonary Hemosiderosis
Pallor ORPHA:99931
Aicardi-Goutieres Syndrome 7
Edema, Pericardial effusion, Intrauterine growth retardation, Hypertrophic cardiomyopathy, Oligoh... OMIM:615846
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Pallor ORPHA:263455
American Trypanosomiasis
Pallor ORPHA:3386
Dominant Beta-Thalassemia
Bowing of the long bones, Skin ulcer, Genu valgum, Growth delay, Pallor, Delayed puberty ORPHA:231226
Hereditary Spherocytosis
Growth delay, Pallor, Skin ulcer ORPHA:822
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Growth delay, Pallor ORPHA:300298
Chédiak-Higashi Syndrome
Pericardial effusion, Pleural effusion, Edema ORPHA:167
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Letterer-Siwe Disease
Pallor OMIM:246400
Beta-Thalassemia Major
Bowing of the long bones, Skin ulcer, Genu valgum, Growth delay, Pallor, Delayed puberty ORPHA:231214
Hereditary Folate Malabsorption
Pallor ORPHA:90045
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Sepsis In Premature Infants
Pallor, Petechiae, Purpura ORPHA:90051
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Fanconi Anemia, Complementation Group C
Anemic pallor, Short stature, Absent thumb, Absent radius, Short thumb, Intrauterine growth retar... OMIM:227645
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Growth delay, Anemic pallor ORPHA:329971
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Kidney Tubulopathy-Dilated Cardiomyopathy Syndrome
Pericardial effusion, Dilated cardiomyopathy, Pulmonary edema ORPHA:73224
Diamond-Blackfan Anemia 1
Short stature, Absent thumb, Short thumb, Partial duplication of thumb phalanx, Hypoplasia of the... OMIM:105650
Beta-Ketothiolase Deficiency
Pallor ORPHA:134
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Waldenström Macroglobulinemia
Pallor, Purpura ORPHA:33226
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor ORPHA:331206
Lymphangioleiomyomatosis
Ascites, Chylothorax, Chylopericardium, Lymphedema ORPHA:538
Tsh-Secreting Pituitary Adenoma
Pericardial effusion, Delayed puberty ORPHA:91347
Imerslund-Gräsbeck Syndrome
Pallor ORPHA:35858
Aregenerative Anemia
Pallor ORPHA:101096
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Prolactinoma
Pallor, Delayed puberty ORPHA:2965
Fanconi Anemia, Complementation Group E
Anemic pallor, Short stature, Absent thumb, Absent radius, Short thumb, Complete duplication of t... OMIM:600901
Adenohypophysitis
Pallor ORPHA:95512
Retinitis Pigmentosa And Erythrocytic Microcytosis
Pallor OMIM:616959
Incontinentia Pigmenti
Erythema, Short stature, Pallor OMIM:308300
Gitelman Syndrome
Pericardial effusion, Delayed puberty ORPHA:358
Panhypophysitis
Pallor ORPHA:95513
3-Hydroxy-3-Methylglutaric Aciduria
Pallor ORPHA:20
Fanconi Anemia, Complementation Group A
Anemic pallor, Short stature, Absent thumb, Absent radius, Short thumb, Complete duplication of t... OMIM:227650
Sheehan Syndrome
Dry skin, Pallor ORPHA:91355
Pituitary Apoplexy
Pallor ORPHA:95613
Hereditary Pheochromocytoma-Paraganglioma
Pallor ORPHA:29072
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor ORPHA:98849
Refractory Anemia With Excess Blasts
Anemic pallor ORPHA:86839
Fumarase Deficiency
Pallor OMIM:606812
Crimean-Congo Hemorrhagic Fever
Pericardial effusion, Myocarditis, Ascites ORPHA:99827
Sarcoidosis, Susceptibility To, 1
Pericardial effusion, Pleural effusion OMIM:181000
Esophageal Atresia
Growth delay, Clinodactyly, Pallor ORPHA:1199
Alternating Hemiplegia Of Childhood
Pallor ORPHA:2131
Degcags Syndrome
Syndactyly, Toe syndactyly, Short thumb, Preaxial hand polydactyly, Genu valgum, Polydactyly, Pal... OMIM:619488
Fanconi Anemia, Complementation Group D2
Anemic pallor, Short stature, Absent thumb, Absent radius, Preaxial hand polydactyly, Short thumb... OMIM:227646
Generalized Arterial Calcification Of Infancy
Ventricular hypertrophy, Polyhydramnios, Edema, Pericardial effusion, Cardiomegaly, Hydrops fetal... ORPHA:51608
Diamond-Blackfan Anemia
Short stature, Absent thumb, Short thumb, Partial duplication of thumb phalanx, Growth delay, Pal... ORPHA:124
Pearson Marrow-Pancreas Syndrome
Erythema, Pallor OMIM:557000
Autosomal Recessive Malignant Osteopetrosis
Growth delay, Abnormal metaphysis morphology, Pallor, Bowing of the long bones ORPHA:667
Idiopathic Hypereosinophilic Syndrome
Swelling of proximal interphalangeal joints, Clubbing, Pallor ORPHA:3260
Histiocytoid Cardiomyopathy
Pallor ORPHA:137675
Infection-Related Hemolytic Uremic Syndrome
Pallor ORPHA:544482
Multiple Endocrine Neoplasia Type 2
Pallor ORPHA:653
Von Hippel-Lindau Disease
Pallor ORPHA:892
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Pmm2-Cdg
Pericarditis, Lymphedema, Pericardial effusion, Anasarca, Hypertrophic cardiomyopathy ORPHA:79318
Goodpasture Syndrome
Pallor OMIM:233450
Lymphatic Malformation 6
Genital edema, Short stature, Nonimmune hydrops fetalis, Polyhydramnios, Edema, Facial edema, Per... OMIM:616843
Congenital Total Pulmonary Venous Return Anomaly
Pallor ORPHA:99125
Dehydrated Hereditary Stomatocytosis
Increased circulating lactate dehydrogenase concentration, Pulmonary venous hypertension, Intermi... ORPHA:3202
Milroy Disease
Predominantly lower limb lymphedema, Pedal edema, Lymphedema ORPHA:79452

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Piezo1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Piezo1.

There are 18 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development. Bone research (February 2024) Piezo1tm1c(KOMP)Wtsi PMC10891122
The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration. Life science alliance (November 2022) Piezo1tm1c(KOMP)Wtsi Piezo1tm1a(KOMP)Wtsi PMC9711862
Mechanosensation by endothelial PIEZO1 is required for leukocyte diapedesis. Blood (July 2022) Piezo1tm1a(KOMP)Wtsi 35443048
Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity. The Journal of clinical investigation (March 2022) Piezo1tm1c(KOMP)Wtsi PMC8884896
Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels. Cell reports (October 2020) Piezo1tm1c(KOMP)Wtsi PMC7539531
RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis. Cell (July 2020) Piezo1tm1c(KOMP)Wtsi Piezo1tm1a(KOMP)Wtsi 32640190
Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells. eLife (June 2020) Piezo1tm1c(KOMP)Wtsi PMC7295575
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. Nature communications (May 2020) Piezo1tm1b(KOMP)Wtsi PMC7211025
Alveolar Stretch Activation of Endothelial Piezo1 Protects Adherens Junctions and Lung Vascular Barrier. American journal of respiratory cell and molecular biology (February 2020) Piezo1tm1c(KOMP)Wtsi PMC6993544
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk. Nature communications (January 2020) Piezo1tm1a(KOMP)Wtsi PMC6962448
Piezo1 channel activation mimics high glucose as a stimulator of insulin release. Scientific reports (November 2019) Piezo1tm1a(KOMP)Wtsi PMC6856185
Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. The Journal of biological chemistry (October 2019) Piezo1tm1a(KOMP)Wtsi PMC6873183
Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions. Proceedings of the National Academy of Sciences of the United States of America (June 2019) Piezo1tm1c(KOMP)Wtsi PMC6600969
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling. American journal of physiology. Cell physiology (November 2018) Piezo1tm1c(KOMP)Wtsi 30427721
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance. Nature communications (August 2017) Piezo1tm1c(KOMP)Wtsi PMC5571199
Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. The Journal of clinical investigation (October 2016) Piezo1tm1a(KOMP)Wtsi PMC5127677
Piezo1 links mechanical forces to red blood cell volume. eLife (May 2015) Piezo1tm1a(KOMP)Wtsi PMC4456639
Piezo1 integration of vascular architecture with physiological force. Nature (August 2014) Piezo1tm1c(KOMP)Wtsi Piezo1tm1a(KOMP)Wtsi PMC4230887

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MGI Allele Allele Type Produced
Piezo1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice, Tissue
Piezo1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Piezo1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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