Gene: Prdm14

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Prdm14em1(IMPC)Bay HOM Early adult 2.29×10-07
decreased lean body mass Prdm14tm1b(EUCOMM)Wtsi HOM Early adult 2.63×10-07
abnormal bone structure Prdm14em1(IMPC)Bay HOM Early adult 6.54×10-05
decreased bone mineral content Prdm14tm1a(EUCOMM)Wtsi HOM Early adult 1.21×10-18
decreased bone mineral content Prdm14tm1b(EUCOMM)Wtsi HOM Early adult 8.29×10-26
increased total body fat amount Prdm14tm1b(EUCOMM)Wtsi HOM Early adult 2.20×10-09
decreased bone mineral content Prdm14em1(IMPC)Bay HOM Early adult 1.21×10-09
decreased grip strength Prdm14em1(IMPC)Bay HOM Early adult 7.59×10-05
decreased bone mineral density Prdm14tm1b(EUCOMM)Wtsi HOM Early adult 4.05×10-22
abnormal rib morphology Prdm14tm1b(EUCOMM)Wtsi HOM Early adult 3.40×10-05
impaired glucose tolerance Prdm14tm1a(EUCOMM)Wtsi HOM Early adult 2.78×10-06
abnormal bone structure Prdm14tm1b(EUCOMM)Wtsi HOM Early adult 1.91×10-16
decreased lean body mass Prdm14tm1a(EUCOMM)Wtsi HOM Early adult 3.49×10-09
decreased heart rate variability Prdm14em1(IMPC)Bay HOM Early adult 4.66×10-05
increased total body fat amount Prdm14tm1a(EUCOMM)Wtsi HOM Early adult 2.82×10-08
decreased bone mineral density Prdm14em1(IMPC)Bay HOM Early adult 3.16×10-16
hypoactivity Prdm14em1(IMPC)Bay HOM Early adult 3.24×10-06
hyperactivity Prdm14tm1a(EUCOMM)Wtsi HOM Early adult 8.74×10-12
abnormal bone structure Prdm14tm1a(EUCOMM)Wtsi HOM Early adult 8.12×10-07
long tibia Prdm14tm1b(EUCOMM)Wtsi HOM   Early adult 2.07×10-05
decreased bone mineral density Prdm14tm1a(EUCOMM)Wtsi HOM Early adult 3.22×10-26
increased total body fat amount Prdm14em1(IMPC)Bay HOM Early adult 5.36×10-08

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (4/583) N/A
Aorta 4 No  (1/583) N/A
Bone 4 No N/A
Brain 4 No  (4/583) N/A
Brainstem 4 No  (2/583) N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No  (1/583) N/A
Cecum 4 No  (12/371) N/A
Cerebellum 4 No  (3/583) N/A
Cerebral cortex 4 No  (2/583) N/A
Esophagus 4 No  (7/407) N/A
Eye 4 No N/A
Gall bladder 4 No N/A
Heart 4 No  (2/583) N/A
Hippocampus 4 No  (3/583) N/A
Hypothalamus 4 No  (2/583) N/A
Kidney 4 No  (21/583) N/A
Large intestine 4 No  (10/583) N/A
Liver 4 No N/A
Lower urinary tract 4 No  (1/583) N/A
Lung 4 No  (2/583) N/A
Lymph node 4 No  (1/583) N/A
Mammary gland 4 No N/A
Olfactory lobe 4 No  (2/583) N/A
Oral epithelium 4 No N/A
Ovary 4 No  (1/583) N/A
Oviduct 4 No N/A
Pancreas 4 No  (5/583) N/A
Parathyroid gland 4 No  (1/563) N/A
Peripheral nervous system 4 No  (2/583) N/A
Peyer's patch 4 No N/A
Pituitary gland 4 No  (1/583) N/A
Prostate gland 4 No  (12/583) N/A
Skeletal muscle 4 No N/A
Skin 4 No  (1/583) N/A
Small intestine 4 No  (9/583) N/A
Spinal cord 4 No  (3/583) N/A
Spleen 4 No  (3/583) N/A
Stomach 4 No  (13/583) N/A
Striatum 4 No  (3/583) N/A
Testis 4 No  (6/583) N/A
Thymus 4 No  (1/583) N/A
Thyroid gland 4 No  (17/583) N/A
Trachea 4 No  (3/583) N/A
Trigeminal V nerve 4 No N/A
Uterus 4 No N/A
Vas deferens 4 No  (15/382) N/A
Vascular system 4 No N/A
White adipose tissue 4 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Histopathology
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
31 Images
X-ray: XRay Images Skull Lateral Orientation
31 Images
X-ray: XRay Images Whole Body Dorso Ventral
31 Images
X-ray: XRay Images Whole Body Lateral Orientation
30 Images
X-ray: XRay Images Forepaw
31 Images
Eye Morphology: VIP of left fundus
1 Images
Eye Morphology: VIP of right fundus
1 Images
Eye Morphology: VIP of left eye
1 Images
Eye Morphology: VIP of right eye
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Testes - defective growth and differentiation process Prdm14tm1b(EUCOMM)Wtsi HOM Early adult
Tibia - developmental and structural abnormality Prdm14tm1b(EUCOMM)Wtsi HOM Early adult
Ovary - defective growth and differentiation process Prdm14tm1b(EUCOMM)Wtsi HOM Early adult
Tibia - MPATH diagnostic term osteopenia Prdm14tm1b(EUCOMM)Wtsi HOM Early adult
Epididymis - hypoplasia Prdm14tm1b(EUCOMM)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Prdm14tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells, Tissue
Prdm14em1(IMPC)Bay Exon Deletion Mice, Tissue
Prdm14tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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