Gene: Lin28b

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Name
lin-28 homolog B (C. elegans)
MGI ID
MGI:3584032
Synonyms
D030047M17Rik 2810403D23Rik
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
shortened RR interval Lin28btm1b(EUCOMM)Hmgu HOM Early adult 2.08×10-06
abnormal sleep behavior Lin28btm1b(EUCOMM)Hmgu HOM   Early adult 4.65×10-05
hypoactivity Lin28btm1b(EUCOMM)Hmgu HOM Early adult 7.62×10-06
shortened ST segment Lin28btm1b(EUCOMM)Hmgu HOM   Early adult 3.11×10-05
increased heart rate Lin28btm1b(EUCOMM)Hmgu HOM Early adult 1.91×10-06

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Brain 2 No  (3/590)  (2/2)  Section images
Brainstem 2 No  (2/590)  (2/2)  Section images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590)  (2/2)  Section images
Cerebral cortex 2 No  (2/590)  (2/2)  Section images
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Section images
Heart 2 No  (1/590)  (2/2)  Section images
Hippocampus 2 No  (3/590)  (2/2)  Section images
Hypothalamus 2 No  (2/590)  (2/2)  Section images
Kidney 2 No  (20/590)  (2/2)  Section images
Large intestine 2 No  (10/590) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/590)  (2/2)  Section images
Ovary 2 No  (1/590)  (1/2)  Section images
Oviduct 2 No N/A
Pancreas 2 No  (5/590) N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590)  (2/2)  Section images
Prostate gland 2 No  (12/590) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590) N/A
Spinal cord 2 No  (2/590)  (2/2)  Section images
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Striatum 2 No  (3/590)  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (1/2)  Section images
Testis 2 No  (5/590)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590) N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (2/3) N/A
Dorsal root ganglion 1  (1/61) N/A
Ear 2  (1/506)  (1/3) N/A
Embryo 2  (1/507)  (2/3)  Wholemount images
Eye 2  (1/506)  (2/3) N/A
Foot 2  (1/506)  (2/3) N/A
Forebrain 2  (1/506)  (2/3) N/A
Forelimb 2  (1/506)  (2/3) N/A
Fronto-nasal process 1  (1/62) Image Only N/A
Hand 2  (1/506)  (2/3) N/A
Head 2  (5/506)  (2/3) N/A
Heart 2  (1/506)  (2/3) N/A
Hindbrain 2  (6/506)  (2/3) N/A
Hindlimb 2  (1/506)  (2/3) N/A
Liver 2  (1/504) N/A
Lung 2  (1/504) N/A
Mandibular process 2  (1/506)  (2/3) N/A
Maxillary process 2  (1/506) N/A
Midbrain 2  (1/506)  (2/3) N/A
Nose 1  (1/76)  (1/1) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/506)  (1/3) N/A
Spinal cord 1  (1/73)  (1/1) N/A
Tail 2  (1/506)  (2/3) N/A
Tail somite 2  (1/506)  (1/3) N/A

 Associated Images

Sleep Wake: Wake state (bmp file)
16 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Eye Morphology: Images Slit Lamp
1 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Forepaw
10 Images
Embryo LacZ: LacZ images wholemount
12 Images
Original Image
Adult LacZ: LacZ Images Section
18 Images
Combined SHIRPA and Dysmorphology
2 Images

 Disease Models

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MGI Allele Allele Type Produced
Lin28btm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Lin28btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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