Genes Phenotypes

Gene: Elmod1

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Name
ELMO/CED-12 domain containing 1
MGI ID
MGI:3583900
Synonyms
N/A
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (52) Measurements chart (556) All data table (1289)
Expression & images (67) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased startle reflex Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 2.44×10-17
decreased body weight Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 2.98×10-26
decreased leukocyte cell number Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 3.24×10-06
decreased prepulse inhibition Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 7.58×10-08
trunk curl Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 5.34×10-11
increased lean body mass Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.37×10-10
abnormal behavior Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 8.22×10-19
abnormal locomotor behavior Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.08×10-16
increased circulating chloride level Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 4.76×10-07
abnormal bone structure Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 6.19×10-07
decreased circulating triglyceride level Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 8.92×10-06
decreased total body fat amount Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 3.61×10-16
decreased bone mineral content Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.09×10-07
tremors Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 9.24×10-05
decreased grip strength Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 5.12×10-10
decreased lean body mass Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 6.45×10-07
decreased spleen weight Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 9.54×10-05
abnormal gait Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 2.85×10-10
tremors Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 2.28×10-09
thrombocytopenia Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 1.43×10-08
decreased hemoglobin content Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 6.94×10-05
thrombocytopenia Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 9.61×10-06
abnormal startle reflex Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 1.98×10-19
increased or absent threshold for auditory brainstem response Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 2.00×10-06
abnormal gait Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 3.16×10-16
decreased grip strength Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 3.37×10-20
increased mean corpuscular volume Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 2.12×10-07
increased red blood cell distribution width Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 2.83×10-13
increased heart weight Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.28×10-05
decreased leukocyte cell number Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 4.47×10-07
increased circulating alkaline phosphatase level Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 2.41×10-12
abnormal iris morphology Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 8.86×10-05
increased startle reflex Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 1.67×10-33
increased hemoglobin content Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 6.94×10-05
mammalian phenotype Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 8.52×10-05
abnormal behavior Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.26×10-19
increased circulating triglyceride level Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 8.92×10-06
absent startle reflex Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 2.33×10-16
abnormal ear morphology Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 4.14×10-16
trunk curl Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 5.42×10-06
increased mean corpuscular hemoglobin Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.66×10-05
decreased prepulse inhibition Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 2.07×10-06
hyperactivity Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.90×10-09
decreased lymphocyte cell number Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.58×10-07
decreased bone mineral density Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.95×10-05
increased blood urea nitrogen level Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 2.89×10-05
decreased monocyte cell number Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 4.29×10-07
abnormal locomotor activation Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 1.22×10-07
increased blood urea nitrogen level Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 4.10×10-08
impaired pupillary reflex Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 2.25×10-10
head bobbing Elmod1tm1b(EUCOMM)Hmgu HOM postnatal 1.50×10-17
abnormal response to tactile stimuli Elmod1tm1a(EUCOMM)Hmgu HOM postnatal 5.98×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
nervous system (5)
Brain expression
Cerebral Cortex expression
Hippocampus expression
Striatum expression
MA:0000168
MA:0000185
MA:0000191
MA:0000891
postnatal mouse (6)
Brain expression
Cerebral Cortex expression
Hippocampus expression
Striatum expression
MA:0000168
MA:0000185
MA:0000191
MA:0000891
reproductive system (1)
Testis expression
MA:0000411
trunk (2)
Spinal cord expression
MA:0000216
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (2/5) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (3/5) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485)  (2/5) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (3/5) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
6 Images
Embryo LacZ: LacZ images wholemount
2 Images
X-ray: XRay Images Hind Leg and Hip
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
17 Images
Echo: M-Mode Images
17 Images
X-ray: XRay Images Dorso Ventral
17 Images
X-ray: XRay Images Lateral Orientation
17 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Elmod1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Elmod1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice