Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
NLR family, pyrin domain containing 1B
Synonyms:
Nalp1b

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nlrp1b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Nlrp1b by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autoinflammation With Arthritis And Dyskeratosis
Increased circulating IgA level, Increased circulating IgG level OMIM:617388
Palmoplantar Carcinoma, Multiple Self-Healing
OMIM:615225
Respiratory Papillomatosis, Juvenile Recurrent, Congenital
OMIM:618803
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1
OMIM:606579

The table below shows human diseases predicted to be associated to Nlrp1b by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autoinflammation With Arthritis And Dyskeratosis
Increased circulating IgA level, Increased circulating IgG level OMIM:617388
Palmoplantar Carcinoma, Multiple Self-Healing
OMIM:615225
Respiratory Papillomatosis, Juvenile Recurrent, Congenital
OMIM:618803
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1
OMIM:606579

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nlrp1b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nlrp1b.

No publications found that use IMPC mice or data for Nlrp1b.

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MGI Allele Allele Type Produced
Nlrp1btm448263(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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