Gene: Agap2 MGI:3580016

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Agap2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Agap2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Diabetes Mellitus, Transient Neonatal, 2
Transient neonatal diabetes mellitus, Type II diabetes mellitus OMIM:610374
Type 2 Diabetes Mellitus
Type II diabetes mellitus, Insulin resistance OMIM:125853
Maturity-Onset Diabetes Of The Young, Type 3
Maturity-onset diabetes of the young, Hyperglycemia, Type II diabetes mellitus OMIM:600496
Pancreatic Beta Cell Agenesis With Neonatal Diabetes Mellitus
Neonatal insulin-dependent diabetes mellitus OMIM:600089
Maturity-Onset Diabetes Of The Young, Type 10
Maturity-onset diabetes of the young, Diabetes mellitus, Hyperglycemia, Diabetic ketoacidosis OMIM:613370
Acanthosis Nigricans With Muscle Cramps And Acral Enlargement
Insulin resistance OMIM:200170
Hyperglycemia, Hyperinsulinemia OMIM:616214
Glycogen Storage Disease 0, Liver
Fasting hypoglycemia, Postprandial hyperglycemia, Neonatal hypoglycemia OMIM:240600
Diabetes Mellitus, Transient Neonatal, 1
Transient neonatal diabetes mellitus, Hyperglycemia OMIM:601410
Maturity-Onset Diabetes Of The Young, Type 14
Maturity-onset diabetes of the young, Diabetes mellitus OMIM:616511
Type 1 Diabetes Mellitus 2
Diabetes mellitus, Type I diabetes mellitus OMIM:125852
Type 1 Diabetes Mellitus 15
Diabetes mellitus, Type I diabetes mellitus OMIM:601666
Hyperinsulinism Due To Insr Deficiency
Hyperinsulinemic hypoglycemia, Insulin resistance, Recurrent hypoglycemia, Hypoglycemia, Fasting ... ORPHA:263458
Type 1 Diabetes Mellitus 6
Diabetes mellitus OMIM:601941
Type 1 Diabetes Mellitus 10
Diabetes mellitus OMIM:601942
Diabetes Mellitus, Ketosis-Prone
Diabetes mellitus, Insulin resistance OMIM:612227
Hypogonadism, Male, With Mental Retardation And Skeletal Anomalies
Hyperglycemia, Glucose intolerance OMIM:307500
Short Stature Due To Primary Acid-Labile Subunit Deficiency
Insulin resistance ORPHA:140941
Diabetes Mellitus, Transient Neonatal, 3
Transient neonatal diabetes mellitus, Hyperglycemia, Maternal diabetes OMIM:610582
Insulin Autoimmune Syndrome
Fasting hypoglycemia, Hyperinsulinemic hypoglycemia, Insulin resistance, Nonketotic hypoglycemia,... ORPHA:411593
3-Hydroxy-3-Methylglutaryl-Coa Synthase Deficiency
Hypoglycemia ORPHA:35701
Cortisone Reductase Deficiency 2
Insulin resistance OMIM:614662
Multiple Symmetric Lipomatosis
Insulin resistance ORPHA:2398
Glucocorticoid Deficiency 3
Recurrent hypoglycemia OMIM:609197
Diabetes Mellitus, Permanent Neonatal, 4
Hyperglycemia, Type I diabetes mellitus, Diabetic ketoacidosis OMIM:618858
Hyperinsulinemic Hypoglycemia, Familial, 7
Hypoglycemic seizures, Hyperinsulinemic hypoglycemia, Hyperinsulinemia, Hypoglycemia OMIM:610021
Cone-Rod Synaptic Disorder Syndrome, Congenital Nonprogressive
Hyperglycemia OMIM:618970
Transient Neonatal Diabetes Mellitus
Maturity-onset diabetes of the young, Maternal diabetes, Hypoinsulinemia, Diabetic ketoacidosis, ... ORPHA:99886
Type 1 Diabetes Mellitus
Hyperglycemia, Diabetes mellitus OMIM:222100
Diabetes Mellitus, Permanent Neonatal, 1
Hyperglycemia, Diabetes mellitus, Type I diabetes mellitus OMIM:606176
Dwarfism, Low-Birth-Weight Type, With Unresponsiveness To Growth Hormone
Hypoglycemia OMIM:223500
Diabetes Mellitus, Permanent Neonatal, 2
Hyperglycemia, Type I diabetes mellitus OMIM:618856
Hyperinsulinemic Hypoglycemia, Familial, 2
Hyperinsulinemic hypoglycemia, Hypoglycemia OMIM:601820
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
Fasting hypoglycemia, Hyperinsulinemia, Postprandial hyperglycemia, Hypoglycemia, Insulin-resista... OMIM:262190
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Hypoglycemic seizures, Neonatal hypoglycemia, Hypoketotic hypoglycemia, Nonketotic hypoglycemia, ... ORPHA:293964
Fructose And Galactose Intolerance
Hypoglycemia OMIM:229500
Body Mass Index Quantitative Trait Locus 19
Insulin resistance OMIM:617885
Lipodystrophy, Familial Partial, Type 6
Diabetes mellitus, Insulin resistance OMIM:615980
Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial
Impaired gluconeogenesis, Hypoglycemia OMIM:261650
Isolated Growth Hormone Deficiency, Type Ia
Hypoglycemia OMIM:262400
Familial Partial Lipodystrophy, Köbberling Type
Diabetes mellitus, Hyperinsulinemia, Insulin resistance ORPHA:79084
Growth Hormone Insensitivity Syndrome
Diabetes mellitus, Hypoglycemia, Type II diabetes mellitus, Insulin resistance ORPHA:181393
Diabetes And Deafness, Maternally Inherited
Hyperglycemia, Type II diabetes mellitus OMIM:520000
Diabetes Mellitus, Permanent Neonatal, 3
Hyperglycemia, Type I diabetes mellitus, Glycosuria OMIM:618857
Mitochondrial Complex Iii Deficiency, Nuclear Type 3
Hypoglycemia OMIM:615158
Morbid Obesity And Spermatogenic Failure
Type II diabetes mellitus, Insulin resistance OMIM:615703
Combined Oxidative Phosphorylation Deficiency 36
Hypoglycemia OMIM:617950
Lipodystrophy, Familial Partial, Type 1
Hyperglycemia, Insulin-resistant diabetes mellitus OMIM:608600
Acanthosis Nigricans-Insulin Resistance-Muscle Cramps-Acral Enlargement Syndrome
Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:90301
Glycogen Storage Disease Due To Glycogen Debranching Enzyme Deficiency
Hypoglycemia ORPHA:366
Acquired Partial Lipodystrophy
Insulin resistance ORPHA:79087
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
Ketotic hypoglycemia, Postprandial hyperglycemia, Glycosuria ORPHA:2089
Abnormal oral glucose tolerance, Hyperinsulinemic hypoglycemia, Neonatal hypoglycemia, Glucose in... ORPHA:552
Lipodystrophy, Familial Partial, Type 3
Hyperglycemia, Maternal diabetes, Hyperinsulinemia, Insulin-resistant diabetes mellitus OMIM:604367
Lipodystrophy, Familial Partial, Type 7
Impaired glucose tolerance, Glucose intolerance, Insulin resistance OMIM:606721
Lipodystrophy, Congenital Generalized, Type 3
Diabetes mellitus, Insulin resistance OMIM:612526
Orthostatic Hypotension 2
Hypoglycemia OMIM:618182
Akt2-Related Familial Partial Lipodystrophy
Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:79085
Mitochondrial Complex Iv Deficiency, Nuclear Type 5
Hyperglycemia, Hypoglycemia OMIM:220111
Hypokalemic Periodic Paralysis
Postprandial hyperglycemia ORPHA:681
Bardet-Biedl Syndrome 9
Hyperglycemia OMIM:615986
Greig Cephalopolysyndactyly Syndrome
Hyperglycemia OMIM:175700
Acth-Independent Macronodular Adrenal Hyperplasia 2
Hyperglycemia OMIM:615954
Dicarboxylic Aminoaciduria
Fasting hypoglycemia OMIM:222730
Insulin-Resistance Syndrome Type B
Abnormal oral glucose tolerance, Fasting hypoglycemia, Hyperinsulinemic hypoglycemia, Hyperinsuli... ORPHA:2298
Donohue Syndrome
Fasting hypoglycemia, Hyperglycemia, Postprandial hyperglycemia, Hyperinsulinemia OMIM:246200
Hypoglycemia ORPHA:79319
Short Syndrome
Hyperglycemia, Glucose intolerance, Insulin-resistant diabetes mellitus OMIM:269880
Microcephalic Primordial Dwarfism-Insulin Resistance Syndrome
Insulin-resistant diabetes mellitus ORPHA:436182
Pancreatic And Cerebellar Agenesis
Hyperglycemia, Diabetes mellitus, Hypoglycemia OMIM:609069
Monocarboxylate Transporter 1 Deficiency
Ketotic hypoglycemia OMIM:616095
Mandibuloacral Dysplasia With Type B Lipodystrophy
Glucose intolerance, Hyperglycemia, Hyperinsulinemia, Insulin-resistant diabetes mellitus OMIM:608612
Pancreatic Agenesis 1
Diabetes mellitus, Neonatal insulin-dependent diabetes mellitus OMIM:260370
Severe Neurodegenerative Syndrome With Lipodystrophy
Hyperinsulinemia, Insulin resistance ORPHA:363400
Placental Insufficiency
Insulin resistance ORPHA:439167
Mandibular Hypoplasia, Deafness, Progeroid Features, And Lipodystrophy Syndrome
Diabetes mellitus, Insulin resistance OMIM:615381
Glucocorticoid Deficiency 2
Recurrent hypoglycemia OMIM:607398
Fanconi-Bickel Syndrome
Fasting hypoglycemia, Postprandial hyperglycemia, Impaired glucose tolerance, Glycosuria, Diabete... ORPHA:2088
Necrotizing Enterocolitis
Hyperglycemia, Abnormal glucose homeostasis ORPHA:391673
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Hypoglycemia, Insulin resistance ORPHA:73272
Lipe-Related Familial Partial Lipodystrophy
Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:435660
Mandibuloacral Dysplasia With Type A Lipodystrophy
Hyperglycemia, Impaired glucose tolerance, Hyperinsulinemia, Insulin-resistant diabetes mellitus OMIM:248370
Pparg-Related Familial Partial Lipodystrophy
Maternal diabetes, Diabetes mellitus, Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:79083
Mandibuloacral Dysplasia
Glucose intolerance, Hyperinsulinemia, Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:2457
Mitchell-Riley Syndrome
Hyperglycemia OMIM:615710
Congenital Generalized Lipodystrophy
Diabetes mellitus, Hyperinsulinemia, Insulin resistance ORPHA:528
Dend Syndrome
Hyperglycemia ORPHA:79134
Familial Partial Lipodystrophy, Dunnigan Type
Diabetes mellitus, Insulin resistance ORPHA:2348
Symptomatic Form Of Hemochromatosis Type 1
Hyperglycemia, Diabetes mellitus ORPHA:465508
Acquired Aneurysmal Subarachnoid Hemorrhage
Hyperglycemia ORPHA:90065
Primary Lipodystrophy
Type II diabetes mellitus, Insulin resistance ORPHA:90970
Thalidomide Embryopathy
Insulin resistance ORPHA:3312
Rabson-Mendenhall Syndrome
Fasting hypoglycemia, Insulin resistance, Postprandial hyperglycemia, Impaired glucose tolerance,... ORPHA:769
Beta-Ketothiolase Deficiency
Hyperglycemia, Hypoglycemia ORPHA:134
Short Syndrome
Diabetes mellitus, Insulin resistance ORPHA:3163
Dopamine Beta-Hydroxylase Deficiency
Hyperinsulinemia, Hypoglycemia, Insulin resistance ORPHA:230
Familial Multiple Lipomatosis
Insulin resistance ORPHA:199276
Seckel Syndrome 10
Glucose intolerance, Insulin resistance, Impaired glucose tolerance, Glycosuria, Diabetes mellitus OMIM:617253
Lipodystrophy, Familial Partial, Type 2
Hyperglycemia, Hyperinsulinemia, Insulin-resistant diabetes mellitus OMIM:151660
Acquired Generalized Lipodystrophy
Hyperinsulinemia, Insulin-resistant diabetes mellitus, Insulin resistance ORPHA:79086
Isolated Permanent Neonatal Diabetes Mellitus
Hyperglycemia, Neonatal insulin-dependent diabetes mellitus, Glycosuria ORPHA:99885
Bangstad Syndrome
Insulin-resistant diabetes mellitus OMIM:210740
Silver-Russell Syndrome
Recurrent hypoglycemia, Insulin resistance ORPHA:813
Isolated Sedoheptulokinase Deficiency
Postprandial hyperglycemia ORPHA:440713
Lipodystrophy, Congenital Generalized, Type 4
Hyperinsulinemia, Insulin resistance OMIM:613327
Marbach-Rustad Progeroid Syndrome
Insulin resistance OMIM:619322
Monosomy 13Q34
Insulin resistance ORPHA:96168
Whipple Disease
Insulin resistance ORPHA:3452
Short Stature, Microcephaly, And Endocrine Dysfunction
Diabetes mellitus, Insulin resistance OMIM:616541
Mandibuloacral Dysplasia With Type B Lipodystrophy
Insulin resistance ORPHA:90154
Pyruvate Carboxylase Deficiency
Hyperglycemia, Hypoglycemia ORPHA:3008
Mandibuloacral Dysplasia With Type A Lipodystrophy
Insulin resistance ORPHA:90153
Autosomal Semi-Dominant Severe Lipodystrophic Laminopathy
Diabetes mellitus, Insulin resistance ORPHA:280365
Werner Syndrome
Type II diabetes mellitus, Insulin resistance ORPHA:902
Fasting hypoglycemia, Hyperinsulinemia, Recurrent infantile hypoglycemia, Insulin resistance, Pos... ORPHA:508
Aromatase Deficiency
Type II diabetes mellitus, Insulin resistance ORPHA:91
Silver-Russell Syndrome Due To Maternal Uniparental Disomy Of Chromosome 7
Fasting hypoglycemia, Insulin resistance ORPHA:96182
Heart Defects, Congenital, And Other Congenital Anomalies
Hyperglycemia, Diabetes mellitus, Glycosuria OMIM:600001
Atypical Werner Syndrome
Hyperinsulinemia, Fasting hyperinsulinemia, Insulin-resistant diabetes mellitus, Glycosuria, Type... ORPHA:79474
Scorpion Envenomation
Hyperglycemia, Glycosuria ORPHA:466677
Gitelman Syndrome
Maternal diabetes, Glucose intolerance, Insulin resistance, Type I diabetes mellitus, Diabetic ke... ORPHA:358
Thyrotoxic Periodic Paralysis
Postprandial hyperglycemia ORPHA:79102
Bloom Syndrome
Diabetes mellitus, Insulin resistance ORPHA:125
Cognitive Impairment-Coarse Facies-Heart Defects-Obesity-Pulmonary Involvement-Short Stature-Skeletal Dysplasia Syndrome
Hyperglycemia ORPHA:444077
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hyperglycemia ORPHA:293987
Steinert Myotonic Dystrophy
Diabetes mellitus, Hyperinsulinemia, Insulin resistance ORPHA:273
Hutchinson-Gilford Progeria Syndrome
Insulin resistance ORPHA:740
Hyperinsulinemia, Insulin resistance ORPHA:79318
Alström Syndrome
Hyperinsulinemia, Type II diabetes mellitus, Insulin resistance ORPHA:64


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Agap2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Agap2.

No publications found that use IMPC mice or data for Agap2.

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MGI Allele Allele Type Produced
Agap2tm115232(L1L2_Pgk_P) Targeting vectors
Agap2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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