Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased mean corpuscular hemoglobin | Klf14tm1.1(KOMP)Vlcg | HOM | Early adult | 1.90×10-05 | ||
increased vertical activity | Klf14tm1.1(KOMP)Vlcg | HOM | Early adult | 5.22×10-05 | ||
increased circulating alanine transaminase level | Klf14tm1.1(KOMP)Vlcg | HOM | Early adult | 8.25×10-06 | ||
increased red blood cell distribution width | Klf14tm1.1(KOMP)Vlcg | HOM | Early adult | 3.31×10-06 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 25% (1 of 4) |
Brain | Wholemount images | heterozygote | 75% (3 of 4) |
Brown adipose tissue | Section images | heterozygote | 25% (1 of 4) |
Cecum | Section images | heterozygote | 75% (3 of 4) |
Colon | Section images | heterozygote | 75% (3 of 4) |
Diaphragm | Section images | heterozygote | 25% (1 of 4) |
Duodenum | Section images | heterozygote | 25% (1 of 4) |
Epididymis | Section images | heterozygote | 50% (2 of 4) |
Esophagus | Section images | heterozygote | 25% (1 of 4) |
Ileum | Section images | heterozygote | 75% (3 of 4) |
Jejunum | Section images | heterozygote | 75% (3 of 4) |
Kidney | Section images | heterozygote | 25% (1 of 4) |
Lung | Section images | heterozygote | 25% (1 of 4) |
Midbrain | Wholemount images | heterozygote | 50% (2 of 4) |
Penis | Section images | heterozygote | 25% (1 of 4) |
Pituitary gland | Section images | heterozygote | 25% (1 of 4) |
Quadriceps | Section images | heterozygote | 25% (1 of 4) |
Skin | Section images | heterozygote | 25% (1 of 4) |
Stomach | Section images | heterozygote | 75% (3 of 4) |
Testis | Section images | heterozygote | 50% (2 of 4) |
Tongue | Wholemount images Section images | heterozygote | 75% (3 of 4) |
Trachea | Section images | heterozygote | 25% (1 of 4) |
Urinary bladder | Section images | heterozygote | 25% (1 of 4) |
Vas deferens | Section images | heterozygote | 50% (2 of 4) |
Vesicular gland | Section images | heterozygote | 25% (1 of 4) |
Aorta | N/A | heterozygote | 0.0% (0 of 4) |
Blood | N/A | heterozygote | Not available |
Bone marrow | N/A | heterozygote | 0.0% (0 of 4) |
Brainstem | N/A | heterozygote | Not available |
Cartilage tissue | N/A | heterozygote | Not available |
Cerebellum | N/A | heterozygote | 0.0% (0 of 4) |
Cerebral cortex | N/A | heterozygote | Not available |
Chest bone | N/A | heterozygote | Not available |
Eye | N/A | heterozygote | 0.0% (0 of 4) |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 4) |
Harderian gland | N/A | heterozygote | 0.0% (0 of 4) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Large intestine | N/A | heterozygote | 75% (3 of 4) |
Liver | N/A | heterozygote | 0.0% (0 of 4) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Olfactory lobe | N/A | heterozygote | 0.0% (0 of 4) |
Ovary | N/A | heterozygote | 0.0% (0 of 4) |
Oviduct | N/A | heterozygote | 0.0% (0 of 4) |
Pancreas | N/A | heterozygote | 0.0% (0 of 4) |
Parathyroid gland | N/A | heterozygote | 0.0% (0 of 4) |
Parotid gland | N/A | heterozygote | 0.0% (0 of 4) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Prostate gland | N/A | heterozygote | 0.0% (0 of 4) |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 4) |
Skeletal muscle | N/A | heterozygote | Not available |
Small intestine | N/A | heterozygote | 75% (3 of 4) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 4) |
Spleen | N/A | heterozygote | 0.0% (0 of 4) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Sublingual gland | N/A | heterozygote | 0.0% (0 of 4) |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 4) |
Thymus | N/A | heterozygote | 0.0% (0 of 4) |
Thyroid gland | N/A | heterozygote | 50% (2 of 4) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 4) |
Uterus | N/A | heterozygote | 0.0% (0 of 4) |
Vagina | N/A | heterozygote | 0.0% (0 of 4) |
Vascular system | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | Not available |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Klf14 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Klf14.
There are 6 publications which use IMPC produced mice or data.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Klf14tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Klf14tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Klf14em2(IMPC)H | Indel | Mice |
Klf14em1(IMPC)H | Indel | Mice |
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