Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
A kinase (PRKA) anchor protein 6
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Akap6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Akap6 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Pulmonary Hypoplasia, Primary
Neonatal death OMIM:265430
Hernia, Anterior Diaphragmatic
Neonatal death OMIM:306950
Epidermolysis Bullosa With Diaphragmatic Hernia
Neonatal death OMIM:226735
Pyknoachondrogenesis
Stillbirth OMIM:265880
Lethal Congenital Contracture Syndrome 3
Neonatal death OMIM:611369
Neutropenia, Lethal Congenital, With Eosinophilia
Neonatal death OMIM:257100
Thanatophoric Dysplasia, Glasgow Variant
Neonatal death OMIM:273680
Mitochondrial Complex I Deficiency, Nuclear Type 30
Neonatal death OMIM:301021
Immunoneurologic Disorder, X-Linked
Neonatal death OMIM:300076
Fetal Akinesia, Respiratory Insufficiency, Microcephaly, Polymicrogyria, And Dysmorphic Facies
Neonatal death OMIM:619602
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Neonatal death OMIM:612138
Lung Agenesis, Congenital Heart Defects, And Thumb Anomalies Syndrome
Neonatal death OMIM:601612
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death OMIM:276822
Arthrogryposis Multiplex Congenita 6
Neonatal death, Death in infancy, Death in childhood OMIM:619334
Medium Chain 3-Ketoacyl-Coa Thiolase Deficiency
Neonatal death OMIM:602199
Larsen-Like Syndrome, Lethal Type
Neonatal death OMIM:245650
Combined Oxidative Phosphorylation Deficiency 21
Neonatal death OMIM:615918
Congenital Arthrogryposis With Anterior Horn Cell Disease
Neonatal death OMIM:611890
Fibuloulnar Aplasia Or Hypoplasia With Renal Abnormalities
Neonatal death OMIM:228940
Mitochondrial Complex I Deficiency, Nuclear Type 35
Neonatal death OMIM:619003
Dyssegmental Dysplasia, Silverman-Handmaker Type
Neonatal death OMIM:224410
Boomerang Dysplasia
Neonatal death OMIM:112310
Ceroid Lipofuscinosis, Neuronal, 10
Neonatal death OMIM:610127
Fetal Gaucher Disease
Neonatal death, Death in infancy, Stillbirth ORPHA:85212
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Neonatal death, Death in infancy, Death in childhood OMIM:245400
Faciocardiomelic Dysplasia, Lethal
Neonatal death OMIM:227270
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Neonatal death, Stillbirth OMIM:236500
Lethal Congenital Contracture Syndrome 1
Neonatal death OMIM:253310
Chondrodysplasia, Lethal, With Long Bone Angulation And Mixed Bone Density
Neonatal death OMIM:601376
Thanatophoric Dysplasia, Type Ii
Neonatal death OMIM:187601
Combined Oxidative Phosphorylation Deficiency 40
Neonatal death, Death in infancy OMIM:618835
Combined Oxidative Phosphorylation Deficiency 42
Neonatal death, Death in infancy OMIM:618839
Myotubular Myopathy With Abnormal Genital Development
Neonatal death, Death in infancy OMIM:300219
Glutamine Deficiency, Congenital
Neonatal death OMIM:610015
Thanatophoric Dysplasia, Type I
Neonatal death OMIM:187600
Bresek Syndrome
Neonatal death ORPHA:85284
Mitochondrial Complex Iv Deficiency, Nuclear Type 12
Neonatal death, Death in infancy, Death in adolescence, Death in childhood OMIM:619055
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 3
Neonatal death OMIM:619362
Surfactant Metabolism Dysfunction, Pulmonary, 1
Neonatal death, Death in infancy OMIM:265120
Epidermolysis Bullosa, Lethal Acantholytic
Neonatal death OMIM:609638
Pontocerebellar Hypoplasia, Hypotonia, And Respiratory Insufficiency Syndrome, Neonatal Lethal
Neonatal death OMIM:618810
Molybdenum Cofactor Deficiency, Complementation Group C
Neonatal death OMIM:615501
Mitochondrial Complex Ii Deficiency, Nuclear Type 3
Neonatal death OMIM:619167
Multiple Acyl-Coa Dehydrogenase Deficiency
Neonatal death OMIM:231680
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease
Neonatal death OMIM:263200
Developmental And Epileptic Encephalopathy 89
Neonatal death, Death in childhood OMIM:619124
Meacham Syndrome
Neonatal death, Death in infancy, Stillbirth, Death in childhood OMIM:608978
Gaucher Disease, Perinatal Lethal
Neonatal death OMIM:608013
Atelosteogenesis, Type I
Neonatal death, Stillbirth OMIM:108720
Surfactant Metabolism Dysfunction, Pulmonary, 3
Neonatal death, Death in infancy OMIM:610921
Raine Syndrome
Neonatal death OMIM:259775
Short-Rib Thoracic Dysplasia 12
Neonatal death OMIM:269860
Greenberg Dysplasia
Neonatal death, Stillbirth OMIM:215140
Pallister-Hall Syndrome
Neonatal death OMIM:146510
Visceral Steatosis, Congenital
Neonatal death OMIM:228100
Renal Dysplasia-Limb Defects Syndrome
Neonatal death OMIM:266910
Short-Rib Thoracic Dysplasia 20 With Polydactyly
Neonatal death OMIM:617925
Fontaine Progeroid Syndrome
Neonatal death, Death in infancy OMIM:612289
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Neonatal death OMIM:265380
Biliary, Renal, Neurologic, And Skeletal Syndrome
Neonatal death OMIM:619534

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Akap6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Akap6.

No publications found that use IMPC mice or data for Akap6.

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MGI Allele Allele Type Produced
Akap6tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Akap6tm269768(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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