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Gene: Tafa3 MGI:3046463

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Gene Summary

Name:
TAFA chemokine like family member 3
Synonyms:
Tafa-3,  Tafa3,  Sam3,  7530404M11Rik,  Fam19a3

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Tafa3em1(IMPC)Mbp HOM   Early adult 0.00
abnormal bone structure Tafa3em1(IMPC)Mbp HOM Early adult 1.59×10-11
abnormal eye morphology Tafa3em1(IMPC)Mbp HOM Early adult 0.00
increased bone mineral content Tafa3em1(IMPC)Mbp HOM Early adult 1.49×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

30 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Human diseases caused by Tafa3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tafa3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Severe Primary Trimethylaminuria
Aggressive behavior, Anxiety, Emotional lability, Low self esteem, Depression, Negative affectivi... ORPHA:468726
Intellectual Developmental Disorder, Autosomal Recessive 25
Delayed speech and language development, Anxiety OMIM:614346
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Attention deficit hyperactivity disorder, Depression OMIM:613003
Autism, Susceptibility To, X-Linked 4
Impulsivity, Aggressive behavior, Attention deficit hyperactivity disorder, Motor tics OMIM:300830
Obsessive-Compulsive Disorder
Collectionism, Skin-picking, Depression, Anxiety OMIM:164230
Intellectual Developmental Disorder, X-Linked 63
Delayed speech and language development, Anxiety OMIM:300387
Gilles De La Tourette Syndrome
Aggressive behavior, Echolalia, Phonic tics, Motor tics, Self-mutilation OMIM:137580
Familial Alzheimer-Like Prion Disease
Depression, Attention deficit hyperactivity disorder, Emotional lability, Anxiety ORPHA:280397
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Aggressive behavior, Bruxism OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Aggressive behavior, Bruxism ORPHA:356996
Panic Disorder 1
Anxiety OMIM:167870
Fraxe Intellectual Disability
Hyperactivity, Aggressive behavior, Recurrent hand flapping, Agitation, Compulsive behaviors, Imp... ORPHA:100973
Intellectual Developmental Disorder, X-Linked 109
Hyperactivity, Aggressive behavior, Recurrent hand flapping, Agitation, Impulsivity, Stereotypica... OMIM:309548
Pandas
Abnormal fear/anxiety-related behavior, Separation insecurity, Tics, Emotional lability, Impulsiv... ORPHA:66624
Severe Intellectual Disability-Progressive Postnatal Microcephaly-Midline Stereotypic Hand Movements Syndrome
Self-injurious behavior, Stereotypical hand wringing, Impaired social interactions, Inappropriate... ORPHA:397933
Dystonia 11, Myoclonic
Anxiety, Depression, Panic attack, Agoraphobia, Alcoholism OMIM:159900
Behavioral Variant Of Frontotemporal Dementia
Inappropriate behavior, Aggressive behavior, Emotional blunting, Apathy, Gait disturbance, Abnorm... ORPHA:275864
Myoclonus-Dystonia Syndrome
Compulsive behaviors, Panic attack, Depression, Anxiety, Personality disorder ORPHA:36899
Epilepsy, Progressive Myoclonic, 12
Ataxia, Dysmetria, Attention deficit hyperactivity disorder, Difficulty walking, Depression, Anxiety OMIM:619191
Childhood Disintegrative Disorder
Abnormal emotion/affect behavior, Impaired social interactions, Abnormal repetitive mannerisms, A... ORPHA:168782
Basal Ganglia Calcification, Idiopathic, 5
Apathy, Depression, Anxiety, Motor tics, Athetosis OMIM:615483
Parasomnia, Sleep Bruxism Type
Bruxism OMIM:606840
Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures
Delayed speech and language development, Inappropriate laughter, Aggressive behavior, Bruxism OMIM:619150
Early-Onset Schizophrenia
Diminished motivation, Abnormal emotion/affect behavior, Shyness, Suicidal ideation, Lack of peer... ORPHA:96369
Foxg1 Syndrome
Paroxysmal bursts of laughter, Impaired social interactions, Stereotypical hand wringing, Inappro... ORPHA:561854
Cdkl5-Deficiency Disorder
Inappropriate laughter, Reduced eye contact, Bruxism, Stereotypical hand wringing ORPHA:505652
Intellectual Developmental Disorder, Autosomal Recessive 38
Aggressive behavior, Echolalia, Delayed speech and language development, Recurrent hand flapping,... OMIM:615516
Neurodevelopmental Disorder With Or Without Autistic Features And/Or Structural Brain Abnormalities
Delayed speech and language development, Recurrent hand flapping, Inappropriate laughter OMIM:618859
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Aggressive behavior, Self-injurious behavior, Shyness, Impaired social interactions, Delayed spee... ORPHA:449291
Intellectual Developmental Disorder With Autism And Macrocephaly
Pronoun reversal, Echolalia, Delayed speech and language development, Recurrent hand flapping, An... OMIM:615032
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Paroxysmal bursts of laughter, Self-injurious behavior, Delayed speech and language development, ... OMIM:618718
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Suicidal ideation, Abnormal repetitive mannerisms, Attention deficit hyperactivity disorder, Depr... ORPHA:98784
2Q23.1 Microdeletion Syndrome
Paroxysmal bursts of laughter, Hyperactivity, Self-injurious behavior, Ataxia, Abnormal repetitiv... ORPHA:228402
Developmental And Speech Delay Due To Sox5 Deficiency
Aggressive behavior, Self-injurious behavior, Delayed speech and language development, Abnormal r... ORPHA:313892
Macrocephaly-Developmental Delay Syndrome
Delayed speech and language development, Self-injurious behavior, Abnormal repetitive mannerisms,... ORPHA:397612
Childhood Absence Epilepsy
Punding, Abnormal social behavior, Low self esteem, Depression, Anxiety ORPHA:64280
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
Delayed speech and language development, Abnormal repetitive mannerisms, Depression, Anxiety, Sel... ORPHA:457240
Christianson Syndrome
Gait ataxia, Truncal ataxia, Abnormal repetitive mannerisms, Inappropriate laughter, Conspicuousl... ORPHA:85278
X-Linked Intellectual Disability, Cantagrel Type
Abnormal repetitive mannerisms, Absent speech ORPHA:85277
Autism Spectrum Disorder Due To Auts2 Deficiency
Hyperactivity, Repetitive compulsive behavior, Abnormal repetitive mannerisms, Compulsive behavio... ORPHA:352490
Atypical Rett Syndrome
Gait ataxia, Inability to walk, Stereotypical hand wringing, Inappropriate crying, Gait disturban... ORPHA:3095
Severe Intellectual Disability And Progressive Spastic Paraplegia
Abnormal repetitive mannerisms, Shyness ORPHA:280763
Trichotillomania
Hair-pulling OMIM:613229
Primary Dystonia, Dyt13 Type
Abnormal repetitive mannerisms ORPHA:98807
Inverted Duplicated Chromosome 15 Syndrome
Aggressive behavior, Echolalia, Self-biting, Severe receptive language delay, Abnormal repetitive... ORPHA:3306
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Delayed speech and language development, Aggressive behavior, Irritability, Abnormal repetitive m... ORPHA:391307
Alazami Syndrome
Stereotypical hand wringing, Abnormal repetitive mannerisms, Anxiety, Abnormal eating behavior, S... ORPHA:319671
Juvenile Neuronal Ceroid Lipofuscinosis
Abnormal repetitive mannerisms, Emotional lability, Loss of ambulation, Depression, Anxiety, Dysp... ORPHA:79264
Angelman Syndrome Due To A Point Mutation
Gait imbalance, Recurrent hand flapping, Happy demeanor, Ataxia, Inappropriate laughter, Tongue t... ORPHA:411511
Late Infantile Neuronal Ceroid Lipofuscinosis
Hyperactivity, Aggressive behavior, Inability to walk, Gait disturbance, Ataxia, Abnormal repetit... ORPHA:168491
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Hypersexuality, Apathy, Repetitive compulsive behavior, Agitation, Polyphagia, Disinhibition OMIM:607485
Neurodevelopmental Disorder With Poor Language And Loss Of Hand Skills
Inappropriate crying, Recurrent hand flapping, Gait disturbance, Agitation, Bruxism OMIM:617903
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Abnormal repetitive mannerisms, Echolalia, Emotional lability, Anxiety ORPHA:927
5Q14.3 Microdeletion Syndrome
Delayed speech and language development, Abnormal repetitive mannerisms ORPHA:228384
Neurodevelopmental Disorder With Movement Abnormalities, Abnormal Gait, And Autistic Features
Hyperactivity, Pica, Tics, Happy demeanor, Ataxia, Tongue thrusting, Stereotypical body rocking, ... OMIM:617865
Intellectual Developmental Disorder, Autosomal Dominant 51
Aggressive behavior, Delayed speech and language development, Recurrent hand flapping, Tics, Abse... OMIM:617788
Fragile X Syndrome
Hyperactivity, Recurrent hand flapping, Self-biting OMIM:300624
Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures
Gait ataxia, Paroxysmal bursts of laughter, Aggressive behavior, Inability to walk, Recurrent han... OMIM:619580
Lamb-Shaffer Syndrome
Delayed speech and language development, Abnormal social behavior, Abnormal repetitive mannerisms ORPHA:530983
4Q21 Microdeletion Syndrome
Delayed speech and language development, Self-injurious behavior, Abnormal repetitive mannerisms ORPHA:238750
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome
Anxiety, Delayed speech and language development, Repetitive compulsive behavior, Speech articula... ORPHA:391372
48,Xxyy Syndrome
Abnormal repetitive mannerisms, Ataxia, Attention deficit hyperactivity disorder, Depression, Anx... ORPHA:10
Intellectual Developmental Disorder, Autosomal Dominant 45
Hyperactivity, Recurrent hand flapping, Attention deficit hyperactivity disorder, Anxiety OMIM:617600
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Reduced eye contact, Abnormal repetitive mannerisms ORPHA:411986
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Hyperactivity, Gait imbalance, Recurrent hand flapping, Happy demeanor, Ataxia, Inappropriate lau... ORPHA:98794
22Q11.2 Duplication Syndrome
Delayed speech and language development, Compulsive behaviors, Abnormal repetitive mannerisms, An... ORPHA:1727
Bilateral Generalized Polymicrogyria
Self-injurious behavior, Abnormal repetitive mannerisms, Oral-pharyngeal dysphagia ORPHA:208447
Transketolase Deficiency
Self-injurious behavior, Delayed speech and language development, Abnormal repetitive mannerisms,... ORPHA:488618
Distal Xq28 Microduplication Syndrome
Aggressive behavior, Tip-toe gait, Self-biting, Impulsivity, Attention deficit hyperactivity diso... ORPHA:293939
Intellectual Developmental Disorder, Autosomal Dominant 38
Aggressive behavior, Hair-pulling, Self-injurious behavior, Absent speech, Bruxism OMIM:616393
Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type
Hostility, Inability to walk, Anxiety, Repetitive compulsive behavior, Ataxia, Depression, Dyspha... OMIM:300260
Rett Syndrome
Inability to walk, Stereotypical hand wringing, Gait disturbance, Agitation, Abnormal repetitive ... ORPHA:778
Microcephaly-Intellectual Disability-Sensorineural Hearing Loss-Epilepsy-Abnormal Muscle Tone Syndrome
Self-injurious behavior, Severe receptive language delay, Absent speech, Abnormal repetitive mann... ORPHA:457351
Proximal 16P11.2 Microdeletion Syndrome
Impaired social interactions, Delayed speech and language development, Moderate receptive languag... ORPHA:261197
Smith-Magenis Syndrome
Self-injurious behavior, Gait disturbance, Abnormal repetitive mannerisms, Attention deficit hype... ORPHA:819
Microcephaly-Corpus Callosum And Cerebellar Vermis Hypoplasia-Facial Dysmorphism-Intellectual Disability Syndrom
Abnormal repetitive mannerisms, Absent speech ORPHA:500159
Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome
Abnormal repetitive mannerisms, Dysphagia ORPHA:572013
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
Gait ataxia, Aggressive behavior, Abnormal repetitive mannerisms, Compulsive behaviors, Attention... ORPHA:476126
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hyperactivity, Hair-pulling, Abnormal repetitive mannerisms, Dysphagia, Irritability ORPHA:447997
Foxg1 Syndrome Due To 14Q12 Microdeletion
Abnormal repetitive mannerisms, Absent speech ORPHA:261144
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome
Aggressive behavior, Delayed speech and language development, Absent speech, Abnormal repetitive ... ORPHA:457279
Rett Syndrome, Congenital Variant
Impaired social interactions, Inappropriate crying, Absent speech, Tongue thrusting, Irritability... OMIM:613454
Optic Atrophy-Intellectual Disability Syndrome
Repetitive compulsive behavior, Absent speech, Compulsive behaviors ORPHA:401777
Choreoacanthocytosis
Hyperactivity, Aggressive behavior, Head-banging, Falls, Anxiety, Self-injurious behavior, Hair-p... ORPHA:2388
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Impaired social interactions, Abnormal repetitive mannerisms, Emotional lability, Delayed social ... ORPHA:300570
Cystinosis
Abnormal repetitive mannerisms, Gait disturbance, Polydipsia ORPHA:213
Prader-Willi Syndrome Due To Translocation
Head-banging, Impaired social interactions, Delayed speech and language development, Happy demean... ORPHA:177907
White-Sutton Syndrome
Aggressive behavior, Self-injurious behavior, Delayed speech and language development, Absent spe... ORPHA:468678
3P25.3 Microdeletion Syndrome
Delayed speech and language development, Abnormal repetitive mannerisms, Absent speech ORPHA:435638
Intellectual Disability-Autism-Speech Apraxia-Craniofacial Dysmorphism Syndrome
Abnormal repetitive mannerisms ORPHA:529965
Infantile Hypotonia-Oculomotor Anomalies-Hyperkinetic Movements-Developmental Delay Syndrome
Self-biting, Repetitive compulsive behavior, Absent speech, Abnormal repetitive mannerisms, Self-... ORPHA:522077
Kleefstra Syndrome
Aggressive behavior, Self-injurious behavior, Delayed speech and language development, Abnormal r... ORPHA:261494
2Q37 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Abnormal repetitive mannerisms, Compulsive behaviors ORPHA:1001
Wiedemann-Steiner Syndrome
Hyperactivity, Aggressive behavior, Abnormal repetitive mannerisms, Anxiety, Dysphagia, Low frust... ORPHA:319182
7Q11.23 Microduplication Syndrome
Hyperactivity, Aggressive behavior, Self-injurious behavior, Abnormal repetitive mannerisms, Dysm... ORPHA:96121
Hydroxykynureninuria
Abnormal repetitive mannerisms ORPHA:79155
Megalocornea-Intellectual Disability Syndrome
Abnormal repetitive mannerisms, Ataxia ORPHA:2479
Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome
Abnormal repetitive mannerisms, Absent speech ORPHA:496641
Nmda Receptor Encephalitis
Hypersexuality, Abnormal repetitive mannerisms, Depression, Anxiety, Language impairment, No soci... ORPHA:217253
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear/anxiety-related behavior, Aggressive behavior, Self-injurious behavior, Impaired so... ORPHA:353281
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation
Delayed speech and language development, Abnormal repetitive mannerisms, Absent speech, Anxiety ORPHA:464311
Tuberous Sclerosis Complex
Hyperactivity, Aggressive behavior, Self-injurious behavior, Repetitive compulsive behavior, Impu... ORPHA:805
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Abnormal repetitive mannerisms, No social interaction, Absent speech ORPHA:508533
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Hyperactivity, Aggressive behavior, Tip-toe gait, Falls, Suicidal ideation, Tics, Repetitive comp... OMIM:619475
Dyrk1A-Related Intellectual Disability Syndrome
Hyperactivity, Gait disturbance, Abnormal repetitive mannerisms, Anxiety ORPHA:464306
Dilated Cardiomyopathy With Ataxia
Repetitive compulsive behavior, Ataxia ORPHA:66634
Intellectual Disability-Seizures-Abnormal Gait-Facial Dysmorphism Syndrome
Delayed speech and language development, Repetitive compulsive behavior, Abnormal repetitive mann... ORPHA:513456
Monosomy 22Q13.3
Delayed speech and language development, Hair-pulling, Bruxism ORPHA:48652
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear/anxiety-related behavior, Aggressive behavior, Self-injurious behavior, Impaired so... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear/anxiety-related behavior, Aggressive behavior, Self-injurious behavior, Impaired so... ORPHA:353277
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Self-injurious behavior, Abnormal repetitive mannerisms ORPHA:468631
Oculocerebrorenal Syndrome Of Lowe
Self-injurious behavior, Abnormal repetitive mannerisms, Compulsive behaviors, Attention deficit ... ORPHA:534
Mucopolysaccharidosis Type 2
Impulsivity, Aggressive behavior, Hyperactivity, Abnormal repetitive mannerisms ORPHA:580
1P36 Deletion Syndrome
Delayed speech and language development, Abnormal repetitive mannerisms, Self-injurious behavior,... ORPHA:1606
Norrie Disease
Self-injurious behavior, Abnormal repetitive mannerisms, Attention deficit hyperactivity disorder... ORPHA:649
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Abnormal repetitive mannerisms ORPHA:508498
Mowat-Wilson Syndrome
Inability to walk, Anxiety, Happy demeanor, Ataxia, Abnormal repetitive mannerisms, Dysphagia, Br... ORPHA:2152
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Happy demeanor, Abnormal repetitive mannerisms, Absent speech, Expressive language delay, Bruxism ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Happy demeanor, Abnormal repetitive mannerisms, Absent speech, Expressive language delay, Bruxism ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tafa3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tafa3.

No publications found that use IMPC mice or data for Tafa3.

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MGI Allele Allele Type Produced
Tafa3em1(IMPC)Mbp Inter-exon deletion Mice, Tissue
Tafa3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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