IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bpi.
There are 12 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Regional Differences in Mucociliary Clearance in the Upper and Lower Airways.||Frontiers in physiology (March 2022)||Bpifb1tm1a(KOMP)Wtsi||PMC8959816|
|Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis.||Frontiers in immunology (April 2021)||Bpiem1(IMPC)J||PMC8107240|
|A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation.||G3 (Bethesda, Md.) (June 2020)||Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi||PMC7263671|
|The parotid secretory protein BPIFA2 is a salivary surfactant that affects LPS action.||Experimental physiology (May 2020)||Bpifa2tm1(KOMP)Vlcg||32390232|
|High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.||Nature immunology (December 2019)||Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi||PMC7338221|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi||PMC6459510|
|Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation.||Scientific data (September 2017)||Bpifb1tm1e(KOMP)Wtsi Bpifb5tm2a(KOMP)Wtsi||PMC5827107|
|Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1.||Genetics (August 2017)||Bpifb1tm1a(KOMP)Wtsi||28851744|
|BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI.||Journal of the American Society of Nephrology : JASN (August 2017)||Bpifa2tm1(KOMP)Vlcg||28775000|
|SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice.||American journal of respiratory cell and molecular biology (April 2012)||Bpifa1tm1(KOMP)Vlcg||PMC3423460|
|SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice.||The American journal of pathology (May 2011)||Bpifa1tm1(KOMP)Vlcg||PMC3081195|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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|MGI Allele||Allele Type||Produced|
|Bpitm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Bpitm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||ES Cells|
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