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Genes Phenotypes Help, News, Blog

Gene: Krt90 MGI:3045312

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Gene Summary

Name:
keratin 90
Synonyms:
4732456N10Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal gait Krt90em1(IMPC)J HOM Early adult 1.78×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

3 Images

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X-ray

XRay Images Whole Body Dorso Ventral

3 Images

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X-ray

XRay Images Whole Body Lateral Orientation

3 Images

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X-ray

XRay Images Forepaw

3 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

3 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

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Human diseases caused by Krt90 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Krt90 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Psychogenic Movement Disorders
Gait disturbance ORPHA:71519
Benign Hereditary Chorea
Gait disturbance ORPHA:1429
Ataxia-Oculomotor Apraxia Type 1
Gait disturbance, Ataxia ORPHA:1168
Early-Onset Generalized Limb-Onset Dystonia
Gait disturbance ORPHA:256
Vertebral Hypersegmentation And Orofacial Anomalies
Supernumerary ribs, Widow's peak, Six lumbar vertebrae, Supernumerary nipple OMIM:619122
Waardenburg Syndrome, Type 1
Supernumerary vertebrae, Premature graying of hair, Thick eyebrow, White forelock, Supernumerary ... OMIM:193500
Postaxial Acrofacial Dysostosis
Short thumb, Supernumerary vertebrae, Supernumerary nipple, Radioulnar synostosis, Hypoplasia of ... OMIM:263750
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Block vertebrae, Supernumerary vertebrae, Short neck, Hemivertebrae, Vertebral fusion, Scoliosis OMIM:271520
3Q29 Microdeletion Syndrome
Clinodactyly of the 5th finger, Six lumbar vertebrae, Tapered finger ORPHA:65286
Simpson-Golabi-Behmel Syndrome, Type 1
Short distal phalanx of finger, Broad thumb, Short nail, Short finger, Supernumerary nipple, Hype... OMIM:312870

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Krt90

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Krt90.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. PloS one (November 2022) Krt90em1(IMPC)J PMC9662738

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Krt90em1(IMPC)J Exon Deletion Mice
Krt90tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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