Arhgef15 | Rho guanine nucleotide exchange factor 15
Physiological systems
21 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Reproductive system Nervous system Hematopoietic system Mortality/aging
17 No significant impact
3 Not tested
Data collections
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:73Adult tissues
0Embryo tissues
| hydrocephaly | 1 supporting dataset | Arhgef15tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| abnormal brain morphology | 1 supporting dataset | Arhgef15tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| preweaning lethality, incomplete penetrance | 1 supporting dataset | Arhgef15tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * | ||
| increased red blood cell distribution width | 1 supporting dataset | Arhgef15tm1.1(KOMP)Vlcg | homozygote | Early adult | 3.03x10-5 | ||
| male infertility | 1 supporting dataset | Arhgef15tm1.1(KOMP)Vlcg | homozygote | Early adult | N/A * |
| | | | | | | | | | |
| adrenal gland | heterozygote | Section images | 50% (1/2) | 0.7% (4/570) |
| aorta | heterozygote | Section images | 100% (2/2) | 0.19% (1/533) |
| blood | heterozygote | n/a | 0% (0/2) | 0% (0/17) |
| bone marrow | heterozygote | n/a | 0% (0/2) | 0% (0/22) |
| brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | Section images | 100% (2/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | n/a | 0.22% (1/454) |
| cecum | heterozygote | Section images | 50% (1/2) | 7.75% (22/284) |
| cerebellum | heterozygote | n/a | 0% (0/2) | 0.56% (3/532) |
Human diseases caused by Arhgef15 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
External links
No external links available for Arhgef15.
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| Arhgef15tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell mouse |
| Arhgef15tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | | mouse |
| Arhgef15tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Arhgef15tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Arhgef15tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Arhgef15tm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |