Gene: Palb2

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Palb2tm1.1(KOMP)Vlcg HOM   E12.5 0.00
increased mean corpuscular hemoglobin Palb2tm1.1(KOMP)Vlcg HET Early adult 7.46×10-06
decreased exploration in new environment Palb2tm1.1(KOMP)Vlcg HET Early adult 1.57×10-07
preweaning lethality, complete penetrance Palb2tm1.1(KOMP)Vlcg HOM   Early adult 0.00
decreased circulating cholesterol level Palb2tm1.1(KOMP)Vlcg HET Early adult 5.11×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583)  (2/2)  Section images
Aorta 2 No  (1/583) N/A
Bone marrow 2 No  (2/2)  Section images
Brain 2 No  (4/583)  (2/2)  Section images
Brainstem 2 No  (2/583)  (2/2)  Section images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583)  (2/2)  Section images
Cerebellum 2 No  (3/583)  (2/2)  Section images
Cerebral cortex 2 No  (2/583)  (2/2)  Section images
Epididymis 2 No  (18/132)  (1/2)  Section images
Esophagus 2 No  (7/407)  (1/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/583)  (2/2)  Section images
Hippocampus 2 No  (3/583)  (2/2)  Section images
Hypothalamus 2 No  (2/583)  (2/2)  Section images
Kidney 2 No  (21/583)  (2/2)  Section images
Large intestine 2 No  (10/583)  (2/2)  Section images
Liver 2 No N/A
Lower urinary tract 2 No  (1/583) N/A
Lung 2 No  (2/583) N/A
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/583)  (2/2)  Section images
Ovary 2 No  (1/583)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/583)  (1/2)  Section images
Peripheral nervous system 2 No  (2/583) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583)  (2/2)  Section images
Prostate gland 2 No  (12/583) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/583) N/A
Small intestine 2 No  (9/583)  (2/2)  Section images
Spinal cord 2 No  (3/583)  (2/2)  Section images
Spleen 2 No  (3/583)  (2/2)  Section images
Stomach 2 No  (13/583)  (2/2)  Section images
Striatum 2 No  (3/583) N/A
Submandibular gland 2 No  (2/130)  (1/2)  Section images
Testis 2 No  (6/583)  (1/2)  Section images
Thalamus 2 No  (2/2)  Section images
Thymus 2 No  (1/583)  (2/2)  Section images
Thyroid gland 2 No  (17/583) N/A
Trachea 2 No  (3/583) N/A
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (2/2) N/A
1  (1/60) Image Only N/A
2  (1/505)  (2/2) N/A
2  (1/506)  (2/2)  Wholemount images
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
1  (1/61) Image Only N/A
1  (1/59)  (1/1) N/A
2  (1/505)  (2/2) N/A
2  (5/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (6/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/503)  (2/2) N/A
2  (1/503)  (1/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/75)  (2/2) N/A
2  (1/503)  (1/2) N/A
2  (1/505)  (2/2) N/A
1  (1/72)  (1/1) N/A
1  (1/55)  (1/1) N/A
2  (1/505)  (1/2) N/A
2  (1/505)  (1/2) N/A
1  (1/60)  (1/1) N/A
1  (1/60)  (1/1) N/A

 Associated Images

X-ray: XRay Images Skull Lateral Orientation
11 Images
Original Image
Adult LacZ: LacZ Images Section
31 Images
Combined SHIRPA and Dysmorphology
5 Images
Embryo LacZ: LacZ images wholemount
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Forepaw
11 Images
Electroretinography: Cone waveform (pdf format)
4 Images
Electroretinography: Rod waveform (pdf format)
4 Images

 Disease Models

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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Palb2tm96762(L1L2_Bact_P) Targeting vectors
Palb2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Palb2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Palb2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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