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Gene: Zmiz1 MGI:3040693

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Gene Summary

Name:
zinc finger, MIZ-type containing 1
Synonyms:
Zimp10,  Rai17

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Zmiz1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Zmiz1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neurodevelopmental Disorder With Dysmorphic Facies And Distal Skeletal Anomalies
Patent ductus arteriosus OMIM:618659

The table below shows human diseases predicted to be associated to Zmiz1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Congenital Heart Block
Pericardial effusion, Patent ductus arteriosus, Pallor, Endocardial fibroelastosis, Intrauterine ... ORPHA:60041
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Pallor ORPHA:46532
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Peripheral Cone Dystrophy
Pallor OMIM:609021
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Benign Paroxysmal Torticollis Of Infancy
Torticollis, Pallor ORPHA:71518
Optic Atrophy 7 With Or Without Auditory Neuropathy
Hypertrophic cardiomyopathy, Pallor OMIM:612989
Optic Atrophy 1
Pallor OMIM:165500
Acute Peripheral Arterial Occlusion
Pallor ORPHA:90064
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Hypertrophic cardiomyopathy, Pallor OMIM:613561
Dermatitis, Atopic
Dry skin, Pallor, Facial erythema OMIM:603165
Thiamine-Responsive Megaloblastic Anemia Syndrome
Atrial septal defect, Ventricular septal defect, Pallor ORPHA:49827
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Pallor ORPHA:2786
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Cyclic Vomiting Syndrome
Cardiomyopathy, Pallor OMIM:500007
Hemoglobin D Disease
Pallor ORPHA:90039
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Breath-Holding Spells
Pallor OMIM:607578
Rheumatic Fever
Pericarditis, Abnormal heart valve morphology, Myocarditis, Erythema, Endocarditis, Abnormal aort... ORPHA:3099
Hyperinsulinism Due To Ucp2 Deficiency
Hypertrophic cardiomyopathy, Pallor ORPHA:276556
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypertrophic cardiomyopathy, Pallor ORPHA:276575
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hypertrophic cardiomyopathy, Pallor ORPHA:276580
Acute Myelomonocytic Leukemia
Pallor ORPHA:517
Fanconi Anemia, Complementation Group I
Ventricular septal defect, Short neck, Pallor, Atrial septal defect, Intrauterine growth retardat... OMIM:609053
X-Linked Sideroblastic Anemia
Pallor ORPHA:75563
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor ORPHA:276608
Beta-Thalassemia
Hypertrophic cardiomyopathy, Pallor, Skin ulcer ORPHA:848
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Myopathic Ehlers-Danlos Syndrome
Congenital muscular torticollis, Pallor ORPHA:536516
Dravet Syndrome
Limited neck range of motion, Pallor ORPHA:33069
Hb Bart'S Hydrops Fetalis
Pericarditis, Pallor ORPHA:163596
Hyperinsulinism Due To Hnf1A Deficiency
Pallor ORPHA:324575
Retinitis Pigmentosa 51
Pallor OMIM:613464
American Trypanosomiasis
Myocarditis, Cardiomyopathy, Pallor ORPHA:3386
Leishmaniasis
Pallor, Skin ulcer ORPHA:507
Anemia, Congenital Dyserythropoietic, Type Ib
Pallor OMIM:615631
Idiopathic Pulmonary Hemosiderosis
Pallor, Cardiomegaly ORPHA:99931
Evans Syndrome
Pallor, Petechiae ORPHA:1959
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Congenital Total Pulmonary Venous Return Anomaly
Atrial situs ambiguous, Ventricular septal defect, Dextrocardia, Mitral atresia, Cardiomegaly, Pa... ORPHA:99125
Primary Myelofibrosis
Ecchymosis, Pallor, Petechiae, Purpura ORPHA:824
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Pallor OMIM:613839
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Pallor OMIM:600462
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Pallor OMIM:611590
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema ORPHA:439218
Deafness-Lymphedema-Leukemia Syndrome
Pallor ORPHA:3226
Acquired Idiopathic Sideroblastic Anemia
Pallor ORPHA:75564
Diamond-Blackfan Anemia 1
Ventricular septal defect, Tricuspid stenosis, Short neck, Coarctation of aorta, Pallor, Webbed n... OMIM:105650
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Pallor OMIM:246450
Irida Syndrome
Pallor ORPHA:209981
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Drug-Induced Autoimmune Hemolytic Anemia
Pallor ORPHA:90037
Cold Agglutinin Disease
Pallor ORPHA:56425
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Pallor ORPHA:263455
Mixed-Type Autoimmune Hemolytic Anemia
Pallor ORPHA:90036
Myelofibrosis
Pallor, Purpura OMIM:254450
Hereditary Spherocytosis
Restrictive cardiomyopathy, Pallor, Skin ulcer ORPHA:822
Anemia, Hypochromic Microcytic, With Iron Overload 2
Pallor OMIM:615234
Pyruvate Kinase Deficiency Of Red Cells
Intrauterine growth retardation, Pallor OMIM:266200
Dominant Beta-Thalassemia
Dilated cardiomyopathy, Pallor, Skin ulcer ORPHA:231226
Retinitis Pigmentosa 75
Pallor OMIM:617023
Fanconi Anemia, Complementation Group D2
Patent ductus arteriosus, Anemic pallor, Abnormal heart morphology OMIM:227646
Degcags Syndrome
Ventricular septal defect, Patent ductus arteriosus, Low posterior hairline, Pallor, Pulmonic ste... OMIM:619488
Diamond-Blackfan Anemia
Ventricular septal defect, Short neck, Coarctation of aorta, Abnormal heart morphology, Pallor, W... ORPHA:124
Tay-Sachs Disease
Pallor OMIM:272800
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Anemia, Sideroblastic, 1
Anemic pallor OMIM:300751
3-Hydroxy-3-Methylglutaric Aciduria
Dilated cardiomyopathy, Pallor ORPHA:20
Autoimmune Hemolytic Anemia, Warm Type
Pallor ORPHA:90033
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Esophageal Atresia
Tetralogy of Fallot, Ventricular septal defect, Pallor, Coarctation of aorta ORPHA:1199
Sepsis In Premature Infants
Pallor, Petechiae, Purpura ORPHA:90051
Myopathy, Mitochondrial, And Ataxia
Pallor OMIM:617675
Fructose-1,6-Bisphosphatase Deficiency
Pallor ORPHA:348
Beta-Thalassemia Major
Dilated cardiomyopathy, Pallor, Skin ulcer ORPHA:231214
Senior-Loken Syndrome 8
Pallor OMIM:616307
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Plummer-Vinson Syndrome
Pallor ORPHA:54028
Childhood Absence Epilepsy
Pallor ORPHA:64280
Fumarase Deficiency
Perimembranous ventricular septal defect, Pallor OMIM:606812
Beta-Ketothiolase Deficiency
Pallor ORPHA:134
Hereditary Folate Malabsorption
Pallor ORPHA:90045
Congenital Dyserythropoietic Anemia Type Iii
Pallor ORPHA:98870
Waldenström Macroglobulinemia
Pallor, Purpura ORPHA:33226
Letterer-Siwe Disease
Pallor OMIM:246400
Non-Functioning Pituitary Adenoma
Pallor ORPHA:91349
Autosomal Recessive Malignant Osteopetrosis
Delayed eruption of teeth, Pulmonary artery stenosis, Abnormal pulmonary valve morphology, Pallor ORPHA:667
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Pallor ORPHA:331206
Alternating Hemiplegia Of Childhood
Cardiomyopathy, Pallor ORPHA:2131
Elliptocytosis 1
Pallor OMIM:611804
Adenohypophysitis
Pallor ORPHA:95512
Imerslund-Gräsbeck Syndrome
Pallor ORPHA:35858
Panhypophysitis
Pallor ORPHA:95513
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Pallor ORPHA:300298
Sheehan Syndrome
Dry skin, Pallor ORPHA:91355
Pituitary Apoplexy
Pallor ORPHA:95613
Incontinentia Pigmenti
Delayed eruption of teeth, Erythema, Pallor OMIM:308300
Aregenerative Anemia
Pallor ORPHA:101096
Histiocytoid Cardiomyopathy
Ventricular septal defect, Pallor, Cardiomegaly ORPHA:137675
Hereditary Pheochromocytoma-Paraganglioma
Pallor ORPHA:29072
Systemic Mastocytosis With Associated Hematologic Neoplasm
Pallor ORPHA:98849
Prolactinoma
Pallor ORPHA:2965
Fanconi Anemia, Complementation Group E
Anemic pallor, Abnormal heart morphology OMIM:600901
Idiopathic Hypereosinophilic Syndrome
Dilated cardiomyopathy, Pallor, Myocardial eosinophilic infiltration ORPHA:3260
Fanconi Anemia, Complementation Group A
Anemic pallor, Abnormal heart morphology OMIM:227650
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Pallor OMIM:194380
Fanconi Anemia, Complementation Group C
Intrauterine growth retardation, Ventricular septal defect, Anemic pallor OMIM:227645
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Pallor OMIM:300908
Refractory Anemia With Excess Blasts
Anemic pallor ORPHA:86839
Retinitis Pigmentosa And Erythrocytic Microcytosis
Pallor OMIM:616959
Pearson Marrow-Pancreas Syndrome
Erythema, Pallor OMIM:557000
Tsh-Secreting Pituitary Adenoma
Pericardial effusion, Pallor ORPHA:91347
Von Hippel-Lindau Disease
Myocarditis, Cardiomyopathy, Pallor ORPHA:892
Infection-Related Hemolytic Uremic Syndrome
Myocarditis, Pallor ORPHA:544482
Multiple Endocrine Neoplasia Type 2
Pallor ORPHA:653
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Anemic pallor ORPHA:329971
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Goodpasture Syndrome
Pallor OMIM:233450
Neurodevelopmental Disorder With Dysmorphic Facies And Distal Skeletal Anomalies
Patent ductus arteriosus OMIM:618659

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Zmiz1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Zmiz1.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development. Blood (August 2018) Zmiz1tm1c(EUCOMM)Hmgu PMC6148450
The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia. Immunity (October 2015) Zmiz1tm1c(EUCOMM)Hmgu Zmiz1tm1a(EUCOMM)Hmgu PMC4654973

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Zmiz1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Zmiz1tm1aNarl KO first allele (reporter-tagged insertion with conditional potential) ES Cells
Zmiz1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Zmiz1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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