Gene Summary

CD226 antigen
Pta1,  DNAM1,  DNAM-1,  TLiSA1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cd226 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd226 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Monocyte Chemotactic Disorder
Cutaneous anergy, Chronic mucocutaneous candidiasis OMIM:252250
Wiskott-Aldrich Syndrome 2
Reduced natural killer cell activity, Eczema, Defective T cell proliferation OMIM:614493
Severe Combined Immunodeficiency, X-Linked
Agammaglobulinemia, Pneumonia, Decreased circulating IgA level, Chronic oral candidiasis, Reduced... OMIM:300400
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Lymphoproliferative Syndrome, X-Linked, 1
Infectious encephalitis, Reduced natural killer cell activity, Decreased circulating antibody lev... OMIM:308240
Immunodeficiency 14B, Autosomal Recessive
Inflammation of the large intestine, Decreased circulating IgA level, Decreased circulating IgG l... OMIM:619281
Immunodeficiency 20
Reduced natural killer cell activity, Recurrent otitis media, Recurrent sinusitis OMIM:615707
Immunodeficiency 81
Recurrent cutaneous abscess formation, Reduced natural killer cell activity, Impaired collagen-in... OMIM:619374
Hemophagocytic Lymphohistiocytosis, Familial, 3
Reduced natural killer cell activity OMIM:608898
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Decreased circulating antibody level, Colitis, Recurrent sinusitis, Abnormal natural killer cell ... OMIM:613101
Autoimmune Lymphoproliferative Syndrome, Type Iii
Lymphoproliferative disorder, Membranous nephropathy, Reduced natural killer cell activity, Recur... OMIM:615559
Immunodeficiency, Common Variable, 2
Bronchiectasis, Decreased circulating IgA level, Impaired T cell function, Decreased circulating ... OMIM:240500
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Abnormality of T cell physiology OMIM:308220
Ectodermal Dysplasia And Immunodeficiency 1
Increased circulating IgA level, Reduced natural killer cell activity, Dysgammaglobulinemia, Incr... OMIM:300291
Autoinflammation With Infantile Enterocolitis
Reduced natural killer cell activity, Skin rash, Enterocolitis OMIM:616050
Familial Hemophagocytic Lymphohistiocytosis
Infectious encephalitis, Erythroderma, Reduced natural killer cell activity, Decreased circulatin... ORPHA:540
Hermansky-Pudlak Syndrome 2
Reduced natural killer cell activity, Chronic oral candidiasis, Recurrent otitis media, Periodont... OMIM:608233
Hemophagocytic Lymphohistiocytosis, Familial, 2
Reduced natural killer cell activity, Infectious encephalitis, Skin rash OMIM:603553


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd226

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd226.

No publications found that use IMPC mice or data for Cd226.

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MGI Allele Allele Type Produced
Cd226tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cd226tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Cd226tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Cd226tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, ES Cells
Cd226tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

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