Gene Summary

Name:
tubulin tyrosine ligase-like family, member 12
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

9 Images

X-ray

XRay Images Whole Body Dorso Ventral

9 Images

Human diseases caused by Ttll12 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ttll12

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ttll12.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Tubulin polyglutamylation differentially regulates microtubule-interacting proteins. The EMBO journal (January 2023) Ttll12tm1a(EUCOMM)Wtsi PMC9975938
Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. The EMBO journal (July 2021) Ttll12tm1a(EUCOMM)Wtsi PMC8408597

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ttll12tm1e(EUCOMM)Wtsi Targeted, non-conditional allele Mice, ES Cells
Ttll12tm1e.1(EUCOMM)Wtsi Promoter excision from Targeted, non-conditional allele Mice
Ttll12tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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