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Gene: Dlgap3 MGI:3039563

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
DLG associated protein 3
Synonyms:
DAP3,  PSD-95/SAP90-binding protein 3,  Prpl8,  SAP90/PSD 95 associated protein 3,  Sapap3

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dlgap3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dlgap3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pandas
Anorexia, Impulsivity, Abnormal fear-induced behavior, Depression, Irritability, Tics, Attention ... ORPHA:66624
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Abnormal fear-induced behavior, Pseudobulbar paralysis, Aggressive behavior ORPHA:208441
Non-Epidermolytic Palmoplantar Keratoderma
Erythema, Skin ulcer ORPHA:2337
Dermatofibrosarcoma Protuberans
Erythema, Skin ulcer ORPHA:31112
Proliferating Trichilemmal Cyst
Skin ulcer ORPHA:492
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Pyoderma gangrenosum OMIM:619986
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Chilblain Lupus 1
Skin ulcer OMIM:610448
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Hyperactivity, Anorexia, Aggressive behavior, Abnormal fear-induced behavior, Irritability, Abnor... ORPHA:3077
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Acral ulceration, Skin ulcer ORPHA:139578
Neuropathy, Hereditary Sensory, Type Iic
Acral ulceration OMIM:614213
Limited Cutaneous Systemic Sclerosis
Skin ulcer, Dysphagia ORPHA:220402
Classic Mycosis Fungoides
Erythema, Dry skin, Skin ulcer ORPHA:2584
Beta-Thalassemia
Irritability, Pallor, Skin ulcer ORPHA:848
Buerger Disease
Skin ulcer ORPHA:36258
Trichotillomania
Hair-pulling, Compulsive behaviors OMIM:613229
Dracunculiasis
Skin ulcer ORPHA:231
Aplasia Cutis Congenita
Skin ulcer ORPHA:1114
Acrogeria
Excessive wrinkled skin, Skin ulcer ORPHA:2500
Hyperkeratosis Lenticularis Perstans
Skin ulcer ORPHA:409
Juvenile Hyaline Fibromatosis
Skin ulcer ORPHA:2028
Aplasia Cutis-Myopia Syndrome
Skin ulcer ORPHA:1117
Leishmaniasis
Skin ulcer, Pallor, Anorexia ORPHA:507
Chilblain Lupus
Skin ulcer ORPHA:90280
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Skin ulcer, Purpura ORPHA:743
Necrobiosis Lipoidica
Erythema, Skin ulcer ORPHA:542592
Takayasu Arteritis
Skin ulcer, Anorexia ORPHA:3287
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Ollier Disease
Skin ulcer ORPHA:296
Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant
Narcolepsy, Depression OMIM:604121
Hereditary Sensory And Autonomic Neuropathy Type 1
Penetrating foot ulcers, Skin ulcer ORPHA:36386
Acrodermatitis Enteropathica
Anorexia, Erythema, Skin ulcer, Emotional lability, Dry skin ORPHA:37
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Flynn-Aird Syndrome
Skin ulcer ORPHA:2047
Bare Lymphocyte Syndrome, Type I
Skin ulcer OMIM:604571
Polyarteritis Nodosa
Erythema, Skin ulcer ORPHA:767
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Porphyria Due To Ala Dehydratase Deficiency
Abnormal fear-induced behavior, Agitation, Restlessness, Depression ORPHA:100924
Narcolepsy 3
Narcolepsy OMIM:609039
Brooke-Spiegler Syndrome
Skin ulcer ORPHA:79493
Reynolds Syndrome
Skin ulcer, Dysphagia ORPHA:779
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Narcolepsy 1
Narcolepsy OMIM:161400
Pyoderma Gangrenosum
Skin vesicle, Skin ulcer ORPHA:48104
Lichen Planopilaris
Skin ulcer ORPHA:525
Cryoglobulinemic Vasculitis
Petechiae, Skin ulcer, Purpura ORPHA:91138
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Papa Syndrome
Skin ulcer ORPHA:69126
Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Acral ulceration OMIM:613115
Dermatoosteolysis, Kirghizian Type
Skin ulcer ORPHA:1657
Narcolepsy 7
Narcolepsy OMIM:614250
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Intellectual Developmental Disorder, Autosomal Dominant 38
Aggressive behavior, Hair-pulling, Self-injurious behavior, Bruxism, Abnormal repetitive mannerisms OMIM:616393
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer, Dysphagia ORPHA:220393
Familial Multiple Nevi Flammei
Skin ulcer ORPHA:624
Gm2 Gangliosidosis, Ab Variant
Abnormal fear-induced behavior, Inappropriate behavior ORPHA:309246
Prolidase Deficiency
Petechiae, Skin ulcer OMIM:170100
X-Linked Agammaglobulinemia
Skin ulcer ORPHA:47
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Giant Cell Arteritis
Skin ulcer, Anorexia, Depression ORPHA:397
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome
Narcolepsy, Depression ORPHA:314404
Prolidase Deficiency
Erythema, Dry skin, Skin ulcer ORPHA:742
Infantile Myofibromatosis
Skin ulcer ORPHA:2591
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Insensitivity To Pain, Congenital, With Anhidrosis
Emotional lability, Hyperactivity, Self-mutilation, Acral ulceration OMIM:256800
Dominant Beta-Thalassemia
Irritability, Pallor, Skin ulcer ORPHA:231226
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Erythema, Skin ulcer ORPHA:659
Calciphylaxis
Skin ulcer ORPHA:280062
Acquired Purpura Fulminans
Pyoderma gangrenosum, Macular purpura ORPHA:49566
Acute Radiation Syndrome
Scaling skin, Skin ulcer ORPHA:454831
Autosomal Dominant Hyper-Ige Syndrome
Skin vesicle, Skin ulcer ORPHA:2314
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Aggressive behavior, Narcolepsy, Depression, Self-injurious behavior, Compulsive behaviors, Emoti... ORPHA:293987
Werner Syndrome
Lack of skin elasticity, Skin ulcer ORPHA:902
Choreoacanthocytosis
Self-mutilation of tongue and lips due to involuntary movements, Hyperactivity, Aggressive behavi... ORPHA:2388
Juvenile Dermatomyositis
Erythema, Dry skin, Skin ulcer, Dysphagia ORPHA:93672
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hyperactivity, Hair-pulling, Irritability, Dysphagia, Abnormal repetitive mannerisms ORPHA:447997
Beta-Thalassemia Major
Irritability, Pallor, Skin ulcer ORPHA:231214
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Skin ulcer ORPHA:86884
Cushing Disease
Fatiguable weakness of proximal limb muscles, Skin ulcer, Depression, Emotional lability, Ecchymo... ORPHA:96253
Neuropathy, Hereditary Sensory And Autonomic, Type Ia
Acral ulceration OMIM:162400
Familial Keratoacanthoma
Skin ulcer ORPHA:493
Niemann-Pick Disease Type C
Aggressive behavior, Narcolepsy, Depression, Disinhibition, Low frustration tolerance, Compulsive... ORPHA:646
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Toxic Epidermal Necrolysis
Polydipsia, Erythema, Skin ulcer, Dysphagia ORPHA:537
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Chronic Mucocutaneous Candidiasis
Erythema, Skin ulcer ORPHA:1334
Microscopic Polyangiitis
Erythema, Skin ulcer ORPHA:727
Immunoglobulin A Vasculitis
Erythema, Skin ulcer, Anorexia, Purpura ORPHA:761
Livedoid Vasculopathy
Ecchymosis, Skin ulcer, Macular purpura ORPHA:542643
Neutrophilic Dermatosis, Acute Febrile
Erythema, Pyoderma gangrenosum OMIM:608068
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Incontinentia Pigmenti
Erythema, Skin ulcer, Attention deficit hyperactivity disorder ORPHA:464
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Infantile Systemic Hyalinosis
Skin ulcer ORPHA:2176
Amoebiasis Due To Free-Living Amoebae
Irritability, Skin ulcer, Restlessness ORPHA:68
Meige Disease
Skin ulcer ORPHA:90186
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Adult Syndrome
Dry skin, Skin ulcer ORPHA:978
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Agitation, Skin ulcer, Purpura OMIM:615688
Chronic Granulomatous Disease
Skin ulcer ORPHA:379
Oculocerebrorenal Syndrome Of Lowe
Skin ulcer, Depression, Self-injurious behavior, Compulsive behaviors, Attention deficit hyperact... ORPHA:534
Pgm3-Cdg
Skin ulcer ORPHA:443811
Systemic Sclerosis
Acral ulceration, Digital ulcer, Dysphagia ORPHA:90291
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Nail-biting, Aggressive behavior, Hair-pulling, Polyphagia, Self-injurious behavior, Fixated inte... OMIM:620330
Neuropathy, Hereditary Sensory And Autonomic, Type Iia
Acral ulceration OMIM:201300
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Hereditary Acrokeratotic Poikiloderma
Erythema, Skin ulcer ORPHA:2907
Dyskeratosis Congenita
Skin vesicle, Skin ulcer ORPHA:1775
Monosomy 22Q13.3
Hair-pulling, Hyperactivity, Agenesis of corpus callosum, Bruxism ORPHA:48652
Primary Sjögren Syndrome
Purpura, Dry skin, Skin ulcer, Depression ORPHA:289390
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Scaling skin, Skin ulcer ORPHA:2526
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Neuropathy, Hereditary Sensory And Autonomic, Type V
Acral ulceration OMIM:608654
Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive
Acral ulceration OMIM:256840
Cushing Syndrome Due To Ectopic Acth Secretion
Anorexia, Fatiguable weakness of proximal limb muscles, Skin ulcer, Depression, Emotional labilit... ORPHA:99889
Hajdu-Cheney Syndrome
Dry skin, Skin ulcer ORPHA:955
Fusariosis
Skin ulcer ORPHA:228119
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Wiskott-Aldrich Syndrome
Petechiae, Skin ulcer, Purpura ORPHA:906
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Ecchymosis, Skin ulcer, Abnormal temper tantrums ORPHA:2072
Chime Syndrome
Erythema, Skin ulcer ORPHA:3474
Sweet Syndrome
Skin vesicle, Pyoderma gangrenosum ORPHA:3243
Charcot-Marie-Tooth Disease Type 4B2
Penetrating foot ulcers ORPHA:99956
Parkes Weber Syndrome
Scaling skin, Skin ulcer ORPHA:90307
African Trypanosomiasis
Irritability, Narcolepsy, Aggressive behavior ORPHA:3385
Malakoplakia
Skin ulcer ORPHA:556
Plague
Dry skin, Skin ulcer, Anorexia, Depression ORPHA:707
Dermatomyositis
Erythema, Dry skin, Skin ulcer ORPHA:221
Chronic Graft Versus Host Disease
Anorexia, Erythema, Skin ulcer, Dysphagia, Skin vesicle ORPHA:99921
Granulomatosis With Polyangiitis
Skin ulcer, Purpura ORPHA:900
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Hyperactivity, Impulsivity, Aggressive behavior, Abnormal fear-induced behavior, Self-injurious b... ORPHA:353281
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Depression, Skin ulcer, Anorexia, Oral-pharyngeal dysphagia ORPHA:95455
Simple Cryoglobulinemia
Acral ulceration, Purpura ORPHA:91139
Blau Syndrome
Skin ulcer OMIM:186580
Atypical Werner Syndrome
Lack of skin elasticity, Skin ulcer ORPHA:79474
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Hyperactivity, Abnormal lateral ventricle morphology, Impulsivity, Aggressive behavior, Abnormal ... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Hyperactivity, Abnormal lateral ventricle morphology, Impulsivity, Aggressive behavior, Abnormal ... ORPHA:353277
Blau Syndrome
Erythema, Dry skin, Skin ulcer ORPHA:90340
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Acral ulceration OMIM:256810
Leprosy
Penetrating foot ulcers, Acral ulceration ORPHA:548
Split Cord Malformation
Penetrating foot ulcers ORPHA:573278
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dlgap3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dlgap3.

No publications found that use IMPC mice or data for Dlgap3.

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MGI Allele Allele Type Produced
Dlgap3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dlgap3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Dlgap3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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