Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

olfactory receptor family 51 subfamily E member 1
Olfr558,  GA_x6K02T2PBJ9-5425951-5426904,  MOR18-1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Or51e1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Or51e1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Familial Cylindromatosis
Telangiectasia of the skin ORPHA:211
Moyamoya Disease 1
Inflammatory arteriopathy, Telangiectasia OMIM:252350
Capillary Malformation-Arteriovenous Malformation 2
Telangiectasia OMIM:618196
Obesity Due To Sim1 Deficiency
Attention deficit hyperactivity disorder, Polyphagia, Hypotension, Postural hypotension with comp... ORPHA:369873
Telangiectasia, Hereditary Hemorrhagic, Type 5
Spontaneous, recurrent epistaxis, Elevated circulating hepatic transaminase concentration, Portal... OMIM:615506
Moyamoya Disease
Telangiectasia ORPHA:2573
Multifocal Atrial Tachycardia
Atrial flutter, Tachycardia, Atrial fibrillation, Effort-induced polymorphic ventricular tachycar... ORPHA:3282
Telangiectasia, Hereditary Benign
Diffuse telangiectasia OMIM:187260
Uv-Sensitive Syndrome 3
Telangiectasia OMIM:614640
Cardiomyopathy, Familial Restrictive, 3
Reduced left ventricular ejection fraction, Abnormal ST segment, Restrictive cardiomyopathy, Hypo... OMIM:612422
Neuroendocrine Tumor Of The Colon
Anorexia, Elevated circulating hepatic transaminase concentration, Melena, Hypotension, Tricuspid... ORPHA:100080
Supravalvular Aortic Stenosis
Angina pectoris, Hypertension, Systolic heart murmur, Arrhythmia, Syncope, Supravalvular aortic s... ORPHA:3193
Cerebral Cavernous Malformations 2
Cerebral hemorrhage, Telangiectasia OMIM:603284
Cutaneous Mastocytoma
Hypotension, Elevated total serum tryptase, Telangiectasia of the skin, Telangiectasia macularis ... ORPHA:79455
Neuroendocrine Tumor Of The Rectum
Anorexia, Elevated circulating hepatic transaminase concentration, Melena, Hypotension, Tricuspid... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Anorexia, Elevated circulating hepatic transaminase concentration, Melena, Hypotension, Tricuspid... ORPHA:100082
Congenital Tricuspid Stenosis
Congestive heart failure, Hypotension, Tricuspid stenosis, Pulmonary arterial hypertension, Tricu... ORPHA:95459
Nipah Virus Disease
Anorexia, Hypotension ORPHA:99825
Carnitine-Acylcarnitine Translocase Deficiency
Reduced tissue carnitine-acylcarnitine translocase activity, Elevated circulating hepatic transam... OMIM:212138
Bronchial Neuroendocrine Tumor
Anorexia, Hypotension, Tricuspid regurgitation, Facial telangiectasia, Right ventricular failure,... ORPHA:97287
Perry Syndrome
Hypotension ORPHA:178509
Tako-Tsubo Cardiomyopathy
Prolonged QT interval, Bradycardia, Palpitations, Low-output congestive heart failure, Mildly red... ORPHA:66529
Neuroendocrine Tumor Of Stomach
Hematemesis, Anorexia, Elevated circulating hepatic transaminase concentration, Melena, Hypotensi... ORPHA:100075
Congenital Isolated Acth Deficiency
Prolonged neonatal jaundice, Hepatitis, Hypotension ORPHA:199296
Tachycardia, Hypotension, Motor stereotypy ORPHA:79155
Snakebite Envenomation
Hypotension, Cerebral ischemia, Neuromuscular dysphagia, Cardiogenic shock, Epistaxis, Intracrani... ORPHA:449285
Mitochondrial Trifunctional Protein Deficiency 2
Hypotension, Tricuspid regurgitation, Elevated circulating alanine aminotransferase concentration... OMIM:620300
Hypotension OMIM:616000
Pulmonary Hypertension, Primary, 1
Elevated right atrial pressure, Hypertension, Pulmonary arterial hypertension, Right ventricular ... OMIM:178600
Atrial Fibrillation, Familial, 14
Paroxysmal atrial fibrillation, ST segment elevation, Hypertension, Prolonged PR interval OMIM:615378
Corticosteroid-Binding Globulin Deficiency
Hypertension, Hypotension OMIM:611489
Cardiogenic Shock
Congestive heart failure, Abnormal left ventricular function, Low-output congestive heart failure... ORPHA:97292
Cutis Marmorata Telangiectatica Congenita
Hypertension, Telangiectasia OMIM:219250
Malignant Hyperthermia, Susceptibility To, 1
Tachycardia, Hypotension OMIM:145600
Adult Acute Respiratory Distress Syndrome
Vasculitis, Hypotension, Shock ORPHA:70578
Infant Acute Respiratory Distress Syndrome
Tachycardia, Cardiac arrest, Hypotension, Bradycardia ORPHA:70587
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Hypotension OMIM:620125
Relapsing Fever
Jaundice, Elevated circulating hepatic transaminase concentration, Hypotension, Increased circula... ORPHA:91547
Aggressive Systemic Mastocytosis
Decreased liver function, Anorexia, Gastrointestinal hemorrhage, Elevated total serum tryptase, H... ORPHA:98850
Mercury Poisoning
Tachycardia, Hypertension, Hypotension, Anorexia ORPHA:330021
Infant Botulism
Anorexia, Hypertension, Cardiac arrest, Hypotension, Dysphagia ORPHA:178478
Inhalational Anthrax
Hypotension, Internal hemorrhage ORPHA:247257
Late-Onset Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension ORPHA:556037
Corticosterone Methyloxidase Type I Deficiency
Hypotension OMIM:203400
Car T Cell Therapy-Associated Cytokine Release Syndrome
Heart block, Elevated circulating hepatic transaminase concentration, Reduced left ventricular ej... ORPHA:542323
Erythrocytosis, Familial, 2
Cerebral hemorrhage, Hypotension, Pulmonary arterial hypertension OMIM:263400
Carnitine-Acylcarnitine Translocase Deficiency
Elevated circulating hepatic transaminase concentration, Cardiomyopathy, Hypotension, Arrhythmia,... ORPHA:159
Serotonin Syndrome
Agitation, Hypertension, Hypotension, Restlessness, Tachycardia, Hepatic failure ORPHA:43116
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hypotension ORPHA:91354
Renal Tubular Dysgenesis
Hypotension OMIM:267430
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension, Dysphagia ORPHA:35708
Early-Onset Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension ORPHA:556030
Pseudohypoaldosteronism, Type Ib1, Autosomal Recessive
Hypotension OMIM:264350
Legionnaires Disease
Myocarditis, Anorexia, Jaundice, Hypotension, Pericarditis, Ataxia, Arrhythmia, Hepatitis ORPHA:549
Acute Radiation Syndrome
Hypotension, Telangiectasia ORPHA:454831
Fragile X-Associated Tremor/Ataxia Syndrome
Hypertension, Hypotension, Compulsive behaviors, Gait ataxia, Gait disturbance, Ataxia, Dysphagia... ORPHA:93256
Systemic Capillary Leak Syndrome
Myocarditis, Pericarditis, Hypotension, Arrhythmia ORPHA:188
Dengue Fever
Cerebral hemorrhage, Gastrointestinal hemorrhage, Epistaxis, Hypotension ORPHA:99828
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension OMIM:177735
Diffuse Cutaneous Mastocytosis
Gastrointestinal hemorrhage, Elevated total serum tryptase, Hypotension ORPHA:79456
Post-Traumatic Pituitary Deficiency
Hypotension ORPHA:95619
Acquired Von Willebrand Syndrome
Gastrointestinal hemorrhage, Aortic regurgitation, Melena, Hypotension, Pulmonic stenosis, Aortic... ORPHA:99147
Meningococcal Meningitis
Anorexia, Hypotension, Shock ORPHA:33475
Ileal Neuroendocrine Tumor
Elevated circulating hepatic transaminase concentration, Tricuspid stenosis, Hypotension, Pulmoni... ORPHA:100078
Aromatic L-Amino Acid Decarboxylase Deficiency
Tongue thrusting, Reduced circulating aromatic L-amino acid decarboxylase activity, Athetosis, Hy... OMIM:608643
Beta-Ketothiolase Deficiency
Anorexia, Agitation, Hypertension, Hypotension, Ataxia, Oral aversion ORPHA:134
Staphylococcal Necrotizing Pneumonia
Addictive alcohol use, Hypotension, Shock ORPHA:36238
Glycogen Storage Disease Of Heart, Lethal Congenital
Congestive heart failure, Bradycardia, ST segment elevation, Cardiomyopathy, Hypotension, Hypertr... OMIM:261740
Scrub Typhus
Myocarditis, Hypotension ORPHA:83317
Congenital Enterovirus Infection
Myocarditis, Cardiomyopathy, Hypotension, Hepatitis, Hepatic failure ORPHA:292
Whipple Disease
Myocarditis, Polydipsia, Gastrointestinal hemorrhage, Anorexia, Hypotension, Pericarditis, Ataxia... ORPHA:3452
Aa Amyloidosis
Hypotension ORPHA:85445
Chromosome 5Q12 Deletion Syndrome
Hypotension OMIM:615668
Anorexia, Agitation, Inability to walk, Hypertension, Hypovolemic shock, Hypotension, Dysphagia ORPHA:2912
Neuroleptic Malignant Syndrome
Agitation, Elevated circulating hepatic transaminase concentration, Bradycardia, Hypertension, Hy... ORPHA:94093
Cocaine Intoxication
Ischemic stroke, Agitation, Prolonged QT interval, Supraventricular arrhythmia, Hypertension, Hyp... ORPHA:90068
Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension, Hypovolemia ORPHA:427
Ethylene Glycol Poisoning
Congestive heart failure, Prolonged QT interval, Atrial fibrillation, Hypertension, Hypotension, ... ORPHA:31826
Hellp Syndrome
Elevated circulating hepatic transaminase concentration, Hypotension, Internal hemorrhage, Increa... ORPHA:244242
Lujo Hemorrhagic Fever
Myocarditis, Elevated circulating hepatic transaminase concentration, Bradycardia, Fulminant hepa... ORPHA:319213
Gitelman Syndrome
Polydipsia, Prolonged QT interval, Hypotension, Ventricular tachycardia, Ataxia, Palpitations, Sa... OMIM:263800
Neuroendocrine Neoplasm Of Appendix
Anorexia, Elevated circulating hepatic transaminase concentration, Tricuspid stenosis, Hypotensio... ORPHA:100079
3-Hydroxy-3-Methylglutaric Aciduria
Anorexia, Jaundice, Elevated circulating hepatic transaminase concentration, Cardiac arrest, Hypo... ORPHA:20
Colchicine Poisoning
Myocarditis, Congestive heart failure, Hypotension, Hypovolemia, Cardiogenic shock, Arrhythmia ORPHA:31824
Hennekam-Beemer Syndrome
Hypotension, Telangiectasia of the skin, Arrhythmia ORPHA:2135
Familial Glucocorticoid Deficiency
Anorexia, Hypotension, Hypertrophic cardiomyopathy ORPHA:361
Necrotizing Enterocolitis
Shock, Hypotension, Bradycardia ORPHA:391673
Hemorrhagic Fever-Renal Syndrome
Hematemesis, Agitation, Elevated circulating hepatic transaminase concentration, Melena, Capillar... ORPHA:340
Late-Onset Isolated Acth Deficiency
Anorexia, Orthostatic hypotension, Hepatitis, Hypotension ORPHA:199299
Crimean-Congo Hemorrhagic Fever
Hematemesis, Bradycardia, Hypertension, Increased circulating lactate dehydrogenase concentration... ORPHA:99827
Alexander Disease
Hypertension, Hypotension, Gait disturbance, Ataxia, Dysphagia, Self-injurious behavior, Sudden c... ORPHA:58
Sepsis In Premature Infants
Decreased liver function, Jaundice, Bradycardia, Hypotension, Tachycardia ORPHA:90051
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Hypertension, Hypotension OMIM:174000
Hereditary Angioedema Type 1
Hypotension, Dysphagia ORPHA:100050
Pde4D Haploinsufficiency Syndrome
Hypotension ORPHA:439822
Exercise-Induced Malignant Hyperthermia
Decreased liver function, Prolonged QT interval, Sinus tachycardia, Abnormal pulse pressure, Hypo... ORPHA:466650
Anorexia, Jaundice, Hypotension, Retinal hemorrhage, Pericarditis, Subconjunctival hemorrhage, El... ORPHA:509
Systemic Mastocytosis With Associated Hematologic Neoplasm
Syncope, Elevated total serum tryptase, Hypotension, Tachycardia ORPHA:98849
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Decreased methionine synthase activity, Decreased methylmalonyl-CoA mutase activity, Bradycardia,... OMIM:277400
Acute Adrenal Insufficiency
Anorexia, Orthostatic hypotension, Hypotension, Hypovolemia, Salt craving, Myocardial infarction ORPHA:95409
Bacterial Toxic-Shock Syndrome
Myocarditis, Capillary leak, Hypotension, Tachycardia, Hepatitis, Shock ORPHA:36234
Lysosomal Acid Lipase Deficiency
Decreased liver function, Jaundice, Elevated circulating hepatic transaminase concentration, Hypo... ORPHA:275761
Tachycardia, Hypovolemic shock, Hypotension ORPHA:173
Autosomal Dominant Hypocalcemia
Congestive heart failure, Hypotension, Arrhythmia ORPHA:428
Pituitary Apoplexy
Hypertension, Hypotension ORPHA:95613
Bartter Syndrome, Type 3
Hypotension OMIM:607364
Acute Liver Failure
Gastrointestinal hemorrhage, Jaundice, Elevated circulating hepatic transaminase concentration, A... ORPHA:90062
Marburg Hemorrhagic Fever
Anorexia, Jaundice, Elevated circulating hepatic transaminase concentration, Aggressive behavior,... ORPHA:99826
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hypotension ORPHA:90791
Non-Functioning Pituitary Adenoma
Hypotension ORPHA:91349
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Hypotension ORPHA:293978
Hypotension ORPHA:2965
Addison Disease
Anorexia, Orthostatic hypotension, Salt craving, Hypotension ORPHA:85138
Tsh-Secreting Pituitary Adenoma
Congestive heart failure, Supraventricular arrhythmia, Hypertension, Hypotension, Ventricular arr... ORPHA:91347
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hypotension, Hypovolemia ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hypotension, Hypovolemia ORPHA:289548
Hematemesis, Anorexia, Hypotension, Unsteady gait, Arrhythmia, Tachycardia ORPHA:707
Non-Acquired Panhypopituitarism
Hypotension ORPHA:90695
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Hypotension, Hypovolemia, Shock ORPHA:90794
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypotension ORPHA:95494


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Or51e1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Or51e1.

No publications found that use IMPC mice or data for Or51e1.

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MGI Allele Allele Type Produced
Or51e1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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