Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
bromodomain and WD repeat domain containing 3
Synonyms:
D030064D06Rik,  Brodl,  LOC236955

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Brwd3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Brwd3 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked 93
Macrocephaly OMIM:300659

The table below shows human diseases predicted to be associated to Brwd3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Intellectual Developmental Disorder, Autosomal Recessive 24
Microcephaly, Growth delay OMIM:614345
Microcephaly 21, Primary, Autosomal Recessive
Microcephaly, Short stature OMIM:617983
Microcephaly 11, Primary, Autosomal Recessive
Microcephaly, Short stature OMIM:615414
Seckel Syndrome 6
Microcephaly, Short stature OMIM:614728
Phosphoserine Phosphatase Deficiency
Postnatal growth retardation, Cerebral atrophy, Microcephaly, Intrauterine growth retardation OMIM:614023
Congenital Herpes Simplex Virus Infection
Microcephaly, Hydranencephaly, Intrauterine growth retardation ORPHA:293
Intellectual Developmental Disorder, X-Linked 93
Macrocephaly OMIM:300659

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Brwd3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Brwd3.

No publications found that use IMPC mice or data for Brwd3.

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MGI Allele Allele Type Produced
Brwd3tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Brwd3tm50273(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Brwd3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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