Gene Summary

Name:
DEAH (Asp-Glu-Ala-His) box polypeptide 37
Synonyms:
LOC381671,  LOC208144

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Dhx37em1(IMPC)J HOM   E9.5 0.00
increased grip strength Dhx37em1(IMPC)J HET Early adult 9.83×10-06
preweaning lethality, complete penetrance Dhx37em1(IMPC)J HOM   Early adult 0.00
increased vertical activity Dhx37em1(IMPC)J HET Early adult 3.01×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

15 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Electroretinography 3

Fundus file

4 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Dhx37 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dhx37 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
46,Xy Complete Gonadal Dysgenesis
ORPHA:242
46,Xy Sex Reversal 11
OMIM:273250
Neurodevelopmental Disorder With Brain Anomalies And With Or Without Vertebral Or Cardiac Anomalies
OMIM:618731
46,Xy Partial Gonadal Dysgenesis
ORPHA:251510
Testicular Regression Syndrome
ORPHA:983

The table below shows human diseases predicted to be associated to Dhx37 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
46,Xy Complete Gonadal Dysgenesis
ORPHA:242
46,Xy Sex Reversal 11
OMIM:273250
Neurodevelopmental Disorder With Brain Anomalies And With Or Without Vertebral Or Cardiac Anomalies
OMIM:618731
46,Xy Partial Gonadal Dysgenesis
ORPHA:251510
Testicular Regression Syndrome
ORPHA:983

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dhx37

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dhx37.

No publications found that use IMPC mice or data for Dhx37.

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MGI Allele Allele Type Produced
Dhx37em1(IMPC)J Exon Deletion Mice
Dhx37tm171111(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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