Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased vertical activity | Dhx37em1(IMPC)J | HET | Early adult | 1.84×10-05 | ||
preweaning lethality, complete penetrance | Dhx37em1(IMPC)J | HOM | Early adult | 0.00 | ||
increased grip strength | Dhx37em1(IMPC)J | HET | Early adult | 9.83×10-06 | ||
embryonic lethality prior to organogenesis | Dhx37em1(IMPC)J | HOM | E9.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Dhx37 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
46,Xy Complete Gonadal Dysgenesis | ORPHA:242 | ||
46,Xy Sex Reversal 11 | OMIM:273250 | ||
Neurodevelopmental Disorder With Brain Anomalies And With Or Without Vertebral Or Cardiac Anomalies | OMIM:618731 | ||
46,Xy Partial Gonadal Dysgenesis | ORPHA:251510 | ||
Testicular Regression Syndrome | ORPHA:983 |
The table below shows human diseases predicted to be associated to Dhx37 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Attention Deficit-Hyperactivity Disorder | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:143465 | |
Schizophrenia 15 | Hyperactivity | OMIM:613950 | |
46,Xy Complete Gonadal Dysgenesis | ORPHA:242 | ||
46,Xy Sex Reversal 11 | OMIM:273250 | ||
Neurodevelopmental Disorder With Brain Anomalies And With Or Without Vertebral Or Cardiac Anomalies | OMIM:618731 | ||
46,Xy Partial Gonadal Dysgenesis | ORPHA:251510 | ||
Testicular Regression Syndrome | ORPHA:983 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Dhx37em1(IMPC)J | Exon Deletion | Mice |
Dhx37tm171111(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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