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Gene: Frmd7 MGI:2686379

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Gene Summary

Name:
FERM domain containing 7
Synonyms:
EG665849,  LOC385354

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

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Legacy Phenotype Associated Images
Frmd7tm1a(KOMP)Wtsi
WT, Female, WTSI
Frmd7tm1a(KOMP)Wtsi
WT, Female, WTSI
Frmd7tm1a(KOMP)Wtsi
WT, Female, WTSI
Frmd7tm1a(KOMP)Wtsi
WT, Female, WTSI
Frmd7tm1a(KOMP)Wtsi
WT, Female, WTSI

View all 85 images

Human diseases caused by Frmd7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Frmd7 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Nystagmus 1, Congenital, X-Linked
OMIM:310700

The table below shows human diseases predicted to be associated to Frmd7 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Nystagmus 1, Congenital, X-Linked
OMIM:310700

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Frmd7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Frmd7.

There are 11 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
EyeLoop: An Open-Source System for High-Speed, Closed-Loop Eye-Tracking. Frontiers in cellular neuroscience (December 2021) Frmd7tm1a(KOMP)Wtsi PMC8696164
Binocular integration of retinal motion information underlies optic flow processing by the cortex. Current biology : CB (January 2021) Frmd7tm1a(KOMP)Wtsi PMC7987724
Characterization of the Frmd7 Knock-Out Mice Generated by the EUCOMM/COMP Repository as a Model for Idiopathic Infantile Nystagmus (IIN). Genes (September 2020) Frmd7tm1a(KOMP)Wtsi 33007925
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Frmd7tm1a(KOMP)Wtsi PMC7263671
A segregated cortical stream for retinal direction selectivity. Nature communications (February 2020) Frmd7tm1a(KOMP)Wtsi PMC7012930
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Frmd7tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Frmd7tm1a(KOMP)Wtsi PMC6459510
Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration. Neuron (December 2018) Frmd7tm1a(KOMP)Wtsi PMC6292977
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Frmd7tm1a(KOMP)Wtsi PMC5827107
Causal evidence for retina-dependent and -independent visual motion computations in mouse cortex. Nature neuroscience (May 2017) Frmd7tm1a(KOMP)Wtsi PMC5490790
Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity. Neuron (December 2015) Frmd7tm1a(KOMP)Wtsi PMC4712192

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MGI Allele Allele Type Produced
Frmd7tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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