Gene Summary

Name:
lysophosphatidic acid receptor 5
Synonyms:
Gpr92,  LPA5,  GPR93,  LOC381810

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

View all 76 images

Human diseases caused by Lpar5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lpar5 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Familial Alzheimer-Like Prion Disease
Deficit in phonologic short-term memory, Cognitive impairment, Emotional lability, Anxiety, Atten... ORPHA:280397
Intellectual Developmental Disorder, Autosomal Recessive 66
Attention deficit hyperactivity disorder, Shyness, Gait ataxia, Aggressive behavior OMIM:618221
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder, Impaired social interactions OMIM:618830
Spinocerebellar Ataxia 14
Impaired vibration sensation at ankles, Dysmetria, Focal dystonia, Progressive cerebellar ataxia,... OMIM:605361
Mental Retardation, Autosomal Dominant 52
Hyperactivity, Anxiety OMIM:617796
Epilepsy, Progressive Myoclonic, 12
Dysmetria, Ataxia, Mental deterioration, Anxiety, Attention deficit hyperactivity disorder, Depre... OMIM:619191
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Dementia, Inappropriate behavior, Shuffling gait, Bradykinesia, Falls, Apathy, Short stepped shuf... ORPHA:412066
Mental Retardation, Autosomal Dominant 45
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617600
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Dystonia, Inappropriate behavior, Chorea, Cognitive impairment, Ataxia, Anxiety, Depression, Memo... ORPHA:401901
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior, Hyperactivity ORPHA:436151
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Hyperactivity, Inability to walk, Irritability OMIM:616657
Mental Retardation, Autosomal Recessive 3
Hyperactivity OMIM:608443
Mental Retardation, Autosomal Recessive 37
Hyperactivity, Aggressive behavior OMIM:615493
Huntington Disease-Like 2
Dystonia, Dementia, Chorea, Apathy, Bradykinesia, Irritability, Anxiety, Depression OMIM:606438
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Aggressive behavior ORPHA:356996
Huntington Disease-Like 1
Dementia, Dysmetria, Chorea, Aggressive behavior, Unsteady gait, Anxiety, Depression OMIM:603218
Juvenile Huntington Disease
Dystonia, Dementia, Chorea, Bradykinesia, Hyperactivity, Progressive cerebellar ataxia, Ataxia, I... ORPHA:248111
Immunodeficiency 8
Hyperactivity OMIM:615401
Developmental And Epileptic Encephalopathy 43
Hyperactivity, Ataxia OMIM:617113
Early-Onset Schizophrenia
Shyness, Unhappy demeanor, Anxiety, Low self esteem, Suicidal ideation, Cognitive impairment, Lac... ORPHA:96369
Basal Ganglia Calcification, Idiopathic, 5
Athetosis, Dementia, Chorea, Cognitive impairment, Apathy, Anxiety, Depression OMIM:615483
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Self-injurious behavior, Hyperactivity, Aggressive behavior, Anxiety OMIM:619031
Pandas
Abnormal fear/anxiety-related behavior, Agoraphobia, Chorea, Claustrophobia, Irritability, Emotio... ORPHA:66624
Mental Retardation, Autosomal Dominant 33
Hyperactivity OMIM:616311
Parkinson Disease 6, Autosomal Recessive Early-Onset
Dystonia, Dementia, Bradykinesia, Anxiety, Depression OMIM:605909
Cognitive Impairment With Or Without Cerebellar Ataxia
Dysmetria, Cognitive impairment, Ataxia, Emotional lability, Attention deficit hyperactivity diso... OMIM:614306
Encephalopathy, Progressive, With Or Without Lipodystrophy
Mental deterioration, Dystonia, Hyperactivity, Ataxia OMIM:615924
Smith-Magenis syndrome
Hyperactivity, Self-mutilation DECIPHER:8
Landau-Kleffner Syndrome
Steppage gait, Aggressive behavior, Social and occupational deterioration, Hyperactivity, Emotion... ORPHA:98818
Gm2 Gangliosidosis, Ab Variant
Dystonia, Abnormal fear/anxiety-related behavior, Inappropriate behavior, Chorea, Cognitive impai... ORPHA:309246
Lennox-Gastaut Syndrome
Aggressive behavior, Falls, Hyperactivity, Personality disorder, Mental deterioration ORPHA:2382
Intellectual Developmental Disorder, X-Linked 104
Hyperactivity, Aggressive behavior, Ataxia, Poor eye contact OMIM:300983
Childhood Disintegrative Disorder
Dementia, Anxiety, Social and occupational deterioration, Mental deterioration, Motor deteriorati... ORPHA:168782
Glycine Encephalopathy
Aggressive behavior, Hyperactivity, Irritability, Impulsivity, Lethargy OMIM:605899
Microcephaly, Seizures, And Developmental Delay
Hyperactivity, Ataxia OMIM:613402
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations
Hyperactivity, Aggressive behavior, Impulsivity OMIM:604317
Dopa-Responsive Dystonia
Gait disturbance, Dystonia, Arm dystonia, Panic attack, Agoraphobia, Inability to walk, Irritabil... ORPHA:255
Hyperprolinemia, Type I
Hyperactivity, Aggressive behavior, Ataxia OMIM:239500
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Attention deficit hyperactivity disorder, Impulsivity OMIM:301008
Intellectual Developmental Disorder, X-Linked 109
Hyperactivity, Aggressive behavior, Impulsivity OMIM:309548
Insulin-Like Growth Factor I Deficiency
Hyperactivity OMIM:608747
Phenylketonuria
Aggressive behavior, Self-mutilation, Hyperactivity, Irritability, Anxiety, Attention deficit hyp... OMIM:261600
Chromosome 3Q29 Deletion Syndrome
Aggressive behavior, Hyperactivity, Anxiety, Gait ataxia OMIM:609425
Mental Retardation, Autosomal Dominant 43
Hyperactivity, Anxiety, Impulsivity OMIM:616977
Fraxe Intellectual Disability
Hyperactivity, Aggressive behavior, Impulsivity ORPHA:100973
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Dysmetria, Gait disturbance, Inability to walk, Hyperactivity OMIM:618090
Pitt-Hopkins-Like Syndrome 1
Aggressive behavior, Hyperactivity, Ataxia, Impaired social interactions, Progressive language de... OMIM:610042
Trigeminal Neuralgia
Paresthesia, Episodic paroxysmal anxiety, Allodynia, Depression, Somatic sensory dysfunction ORPHA:221091
Early-Onset Autosomal Dominant Alzheimer Disease
Dementia, Semantic dementia, Ataxia, Disinhibition, Abnormal social behavior, Memory impairment ORPHA:1020
Mannosidosis, Beta A, Lysosomal
Hyperactivity, Aggressive behavior OMIM:248510
Female Restricted Epilepsy With Intellectual Disability
Aggressive behavior, Hyperactivity, Impulsivity, Abnormal social behavior, Anxiety ORPHA:101039
Cln5 Disease
Dysmetria, Aggressive behavior, Hyperactivity, Inability to walk, Dysdiadochokinesis, Ataxia, Tru... ORPHA:228360
11Q22.2Q22.3 Microdeletion Syndrome
Abnormal social behavior, Anxiety, Attention deficit hyperactivity disorder, Poor eye contact ORPHA:444002
Morm Syndrome
Hyperactivity, Aggressive behavior ORPHA:75858
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Dystonia, Choreoathetosis, Aggressive behavior, Hyperactivity, Ataxia OMIM:612716
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Aggressive behavior, Shuffling gait, Hyperactivity, Irrit... ORPHA:3077
Hyperlysinemia, Type I
Hyperactivity, Cognitive impairment OMIM:238700
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Intellectual Developmental Disorder, Autosomal Recessive 74
Hyperactivity OMIM:617169
Coffin-Siris Syndrome 8
Self-injurious behavior, Hyperactivity, Aggressive behavior OMIM:618362
Autosomal Recessive Non-Syndromic Intellectual Disability
Dystonia, Chorea, Hyperactivity, Impulsivity, Depression ORPHA:88616
Xq25 Microduplication Syndrome
Hyperactivity, Anxiety ORPHA:521258
Chromosome Xq25 Duplication Syndrome
Hyperactivity, Anxiety OMIM:300979
Guanidinoacetate Methyltransferase Deficiency
Athetosis, Dystonia, Self-injurious behavior, Chorea, Aggressive behavior, Hyperactivity, Ataxia ORPHA:382
Aminoacylase 1 Deficiency
Hyperactivity OMIM:609924
X-Linked Adrenoleukodystrophy
Gait disturbance, Dementia, Cognitive impairment, Aggressive behavior, Inappropriate sexual behav... ORPHA:43
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder
Dystonia, Impaired pain sensation, Chorea, Aggressive behavior, Hyperactivity, Inability to walk,... ORPHA:500180
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity, Aggressive behavior OMIM:615541
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617182
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Hyperactivity, Aggressive behavior, Broad-based gait OMIM:619470
Succinic Semialdehyde Dehydrogenase Deficiency
Self-injurious behavior, Aggressive behavior, Hyperactivity, Ataxia, Anxiety OMIM:271980
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Happy demeanor, Inappropriate laughter, Hyperactivity, Ataxia, Broad-based gait ORPHA:411515
Complex Regional Pain Syndrome
Somatic sensory dysfunction, Dysesthesia, Allodynia, Trophic changes related to pain ORPHA:83452
Young-Onset Parkinson Disease
Dystonia, Dementia, Gait imbalance, Cognitive impairment, Frontal lobe dementia, Apathy, Bradykin... ORPHA:2828
X-Linked Intellectual Disability, Stocco Dos Santos Type
Hyperactivity ORPHA:85288
Clcn4-Related X-Linked Intellectual Disability Syndrome
Self-injurious behavior, Chorea, Aggressive behavior, Progressive cerebellar ataxia, Hyperactivit... ORPHA:485350
Rasmussen Subacute Encephalitis
Hemidystonia, Cognitive impairment, Hyperactivity, Inability to walk, Irritability, Emotional lab... ORPHA:1929
Hsd10 Disease
Abnormal social behavior, Gait disturbance, Ataxia, Choreoathetosis ORPHA:391417
Usmani-Riazuddin Syndrome, Autosomal Dominant
Self-injurious behavior, Aggressive behavior, Hyperactivity, Anxiety, Depression OMIM:619467
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity OMIM:300928
Cntnap2-Related Developmental And Epileptic Encephalopathy
Skin-picking, Aggressive behavior, Self-mutilation, Poor eye contact, Hyperactivity, Ataxia, Low ... ORPHA:163681
Neurodegeneration With Brain Iron Accumulation 2B
Dystonia, Dysmetria, Chorea, Bradykinesia, Hyperactivity, Dysdiadochokinesis, Emotional lability,... OMIM:610217
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Shyness, Self-injurious behavior, Aggressive behavior, Poor eye contact, Hyperactivity, Irritabil... ORPHA:449291
Severe Neurodegenerative Syndrome With Lipodystrophy
Progressive psychomotor deterioration, Cognitive impairment, Hyperactivity, Ataxia, Gait ataxia, ... ORPHA:363400
Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Hyperactivity, Aggressive behavior OMIM:618342
Infantile Neuroaxonal Dystrophy
Gait disturbance, Dystonia, Hyperactivity, Ataxia, Emotional lability, Impulsivity, Psychomotor d... ORPHA:35069
Late Infantile Neuronal Ceroid Lipofuscinosis
Gait disturbance, Dementia, Aggressive behavior, Hyperactivity, Inability to walk, Ataxia, Low fr... ORPHA:168491
Intellectual Developmental Disorder, X-Linked 107
Aggressive behavior, Hyperactivity, Attention deficit hyperactivity disorder, Anxiety OMIM:301013
Gand Syndrome
Hyperactivity, Inappropriate laughter OMIM:615074
Metachromatic Leukodystrophy, Adult Form
Progressive psychomotor deterioration, Dementia, Dystonia, Chorea, Progressive gait ataxia, Emoti... ORPHA:309271
Myoclonic-Astatic Epilepsy
Lack of peer relationships, Hyperactivity, Ataxia, Attention deficit hyperactivity disorder, Unst... ORPHA:1942
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Self-injurious behavior, Hyperactivity, Inability to walk, Paroxysmal bursts of laughter OMIM:618718
Dihydropyrimidine Dehydrogenase Deficiency
Hyperactivity, Lethargy OMIM:274270
Ck Syndrome
Hyperactivity, Aggressive behavior, Irritability ORPHA:251383
Mental Retardation, Autosomal Recessive 61
Hyperactivity, Aggressive behavior OMIM:617773
Intellectual Developmental Disorder, Autosomal Recessive 38
Unsteady gait, Hyperactivity, Aggressive behavior, Self-mutilation OMIM:615516
Gomez-Lopez-Hernandez Syndrome
Self-injurious behavior, Cognitive impairment, Hyperactivity, Ataxia, Depression, Bipolar affecti... OMIM:601853
Intellectual Developmental Disorder, X-Linked, Syndromic, Stocco Dos Santos Type
Hyperactivity OMIM:300434
Adenylosuccinase Deficiency
Happy demeanor, Aggressive behavior, Self-mutilation, Poor eye contact, Inappropriate laughter, H... OMIM:103050
Clark-Baraitser Syndrome
Hyperactivity, Aggressive behavior OMIM:617752
Optic Atrophy 11
Dysmetria, Hyperactivity, Ataxia OMIM:617302
Childhood Absence Epilepsy
Low self esteem, Abnormal social behavior, Anxiety, Attention deficit hyperactivity disorder, Dep... ORPHA:64280
Ck Syndrome
Hyperactivity, Aggressive behavior, Irritability OMIM:300831
Anterior Cutaneous Nerve Entrapment Syndrome
Allodynia, Hyperesthesia, Impaired tactile sensation, Somatic sensory dysfunction ORPHA:51890
Neurodevelopmental Disorder With Movement Abnormalities, Abnormal Gait, And Autistic Features
Unsteady gait, Hyperactivity, Happy demeanor, Broad-based gait OMIM:617865
Mental Retardation, X-Linked 77
Hyperactivity OMIM:300454
X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome
Hyperactivity, Aggressive behavior, Broad-based gait ORPHA:457260
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
Metachromatic Leukodystrophy, Juvenile Form
Progressive psychomotor deterioration, Dystonia, Progressive gait ataxia, Emotional lability, Abn... ORPHA:309263
Intellectual Developmental Disorder, X-Linked 30
Aggressive behavior, Hyperactivity, Anxiety OMIM:300558
Lamb-Shaffer Syndrome
Abnormal social behavior, Hyperactivity, Ataxia ORPHA:530983
X-Linked Creatine Transporter Deficiency
Athetosis, Dystonia, Chorea, Self-mutilation, Hyperactivity, Ataxia ORPHA:52503
Mental Retardation, Autosomal Dominant 7
Gait disturbance, Happy demeanor, Inappropriate laughter, Hyperactivity, Ataxia OMIM:614104
Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies
Hyperactivity, Aggressive behavior OMIM:615286
Fragile X Syndrome
Hyperactivity, Poor eye contact OMIM:300624
Mitochondrial Complex Iii Deficiency, Nuclear Type 7
Hyperactivity, Aggressive behavior OMIM:615824
Mucopolysaccharidosis, Type Iiib
Hyperactivity, Aggressive behavior, Progressive neurologic deterioration OMIM:252920
Intellectual Developmental Disorder, X-Linked 21
Hyperactivity, Impulsivity OMIM:300143
2Q23.1 Microdeletion Syndrome
Self-injurious behavior, Hyperactivity, Paroxysmal bursts of laughter, Ataxia ORPHA:228402
Chromosome 2Q37 Deletion Syndrome
Self-injurious behavior, Hyperactivity, Aggressive behavior, Pain insensitivity OMIM:600430
Graves Disease, Susceptibility To, 1
Hyperactivity, Irritability OMIM:275000
Metachromatic Leukodystrophy, Late Infantile Form
Dystonia, Progressive gait ataxia, Emotional lability, Tip-toe gait, Abnormal social behavior, Ga... ORPHA:309256
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Mood swings, Hyperactivity, Aggressive behavior, Gait ataxia OMIM:300354
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type
Hyperactivity, Aggressive behavior, Broad-based gait OMIM:300958
Niemann-Pick Disease Type C
Gait disturbance, Dementia, Dystonia, Axial dystonia, Bipolar affective disorder, Chorea, Cogniti... ORPHA:646
Cri-Du-Chat Syndrome
Aggressive behavior, Conspicuously happy disposition, Self-mutilation, Hyperactivity, Overfriendl... OMIM:123450
Severe Motor And Intellectual Disabilities-Sensorineural Deafness-Dystonia Syndrome
Hyperactivity, Aggressive behavior ORPHA:369939
Neurodegeneration With Brain Iron Accumulation 1
Gait disturbance, Dementia, Dystonia, Choreoathetosis, Bradykinesia, Depression, Hyperactivity, A... OMIM:234200
X-Linked Cerebral Adrenoleukodystrophy
Gait disturbance, Dysmetria, Hyperactivity, Inability to walk, Ataxia, Mental deterioration, Diff... ORPHA:139396
Mental Retardation, Autosomal Recessive 13
Hyperactivity OMIM:613192
Smith-Magenis Syndrome
Hyperactivity, Self-mutilation, Head-banging, Impaired pain sensation OMIM:182290
Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities
Aggressive behavior, Hyperactivity, Anxiety, Ataxia OMIM:618430
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type
Aggressive behavior, Hyperactivity, Emotional lability, Low frustration tolerance, Impaired socia... OMIM:309520
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity, Aggressive behavior ORPHA:85327
47,Xyy Syndrome
Attention deficit hyperactivity disorder, Hyperactivity, Impaired social interactions, Impulsivity ORPHA:8
Developmental Delay-Facial Dysmorphism Syndrome Due To Med13L Deficiency
Overfriendliness, Hyperactivity, Aggressive behavior, Ataxia ORPHA:369891
Hypomagnesemia, Seizures, And Mental Retardation 2
Hyperactivity, Self-biting OMIM:618314
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Hyperactivity, Aggressive behavior, Irritability ORPHA:391307
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Dysmetria, Aggressive behavior, Ataxia, Nonprogressive cerebellar ataxia, Abnormal social behavio... ORPHA:314647
13Q12.3 Microdeletion Syndrome
Hyperactivity, Self-mutilation, Impaired pain sensation ORPHA:412035
Myopathy With Extrapyramidal Signs
Dystonia, Choreoathetosis, Chorea, Hyperactivity, Ataxia, Difficulty walking OMIM:615673
Choreoacanthocytosis
Self-injurious behavior, Oromandibular dystonia, Apathy, Irritability, Anxiety, Hair-pulling, Lin... ORPHA:2388
Angelman Syndrome
Happy demeanor, Self-injurious behavior, Aggressive behavior, Poor eye contact, Inappropriate lau... ORPHA:72
Inverted Duplicated Chromosome 15 Syndrome
Hyperactivity, Aggressive behavior, Self-biting ORPHA:3306
Intellectual Disability-Obesity-Prognathism-Eye And Skin Anomalies Syndrome
Hyperactivity ORPHA:397973
Intellectual Developmental Disorder, Autosomal Recessive 71
Hyperactivity, Attention deficit hyperactivity disorder OMIM:618504
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Gait imbalance, Happy demeanor, Inappropriate laughter, Ataxia, Hyperactivity, Broad-based gait ORPHA:98794
Neurotrophic Keratopathy
Allodynia, Hyperesthesia ORPHA:137596
16P12.1P12.3 Triplication Syndrome
Skin-picking, Hyperactivity, Anxiety, Attention deficit hyperactivity disorder, Nail-biting ORPHA:485405
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Hyperactivity, Gait ataxia, Low frustration tolerance, Self-mutilation OMIM:300486
Chromosome 15Q25 Deletion Syndrome
Hyperactivity, Attention deficit hyperactivity disorder OMIM:614294
Intellectual Developmental Disorder, X-Linked 98
Self-biting, Aggressive behavior, Poor eye contact, Hyperactivity, Ataxia, Anxiety, Impaired soci... OMIM:300912
Insensitivity To Pain, Congenital, With Anhidrosis
Emotional lability, Hyperactivity, Pain insensitivity, Self-mutilation OMIM:256800
Citrullinemia Type Ii
Aggressive behavior, Hyperactivity, Irritability, Memory impairment, Lethargy ORPHA:247585
Potocki-Lupski Syndrome
Hyperactivity, Poor eye contact OMIM:610883
Mucopolysaccharidosis, Type Iiic
Hyperactivity, Motor deterioration OMIM:252930
Severe Intellectual Disability-Poor Language-Strabismus-Grimacing Face-Long Fingers Syndrome
Hyperactivity, Self-mutilation, Low frustration tolerance, Inappropriate laughter ORPHA:363686
Spastic Paraplegia 29, Autosomal Dominant
Hyperactivity, Impaired vibratory sensation OMIM:609727
Angelman Syndrome
Hyperactivity, Paroxysmal bursts of laughter, Progressive gait ataxia, Broad-based gait OMIM:105830
Glass Syndrome
Hyperactivity, Aggressive behavior, Happy demeanor, Broad-based gait OMIM:612313
Intellectual Developmental Disorder, X-Linked, Syndromic, Claes-Jensen Type
Aggressive behavior, Shuffling gait, Hyperactivity, Low frustration tolerance, Pain insensitivity OMIM:300534
48,Xxxy Syndrome
Abnormal aggressive, impulsive or violent behavior, Irritability, Abnormal social behavior, Anxie... ORPHA:96263
Neurodevelopmental Disorder With Or Without Autism Or Seizures
Hyperactivity OMIM:619239
Benign Schwannoma
Allodynia ORPHA:252164
Legius Syndrome
Attention deficit hyperactivity disorder, Dystonia, Cognitive impairment, Hyperactivity ORPHA:137605
Wiedemann-Steiner Syndrome
Aggressive behavior, Hyperactivity, Low frustration tolerance, Psychomotor deterioration, Anxiety ORPHA:319182
Hereditary Sensory And Autonomic Neuropathy Type 4
Trophic limb changes, Impaired temperature sensation, Self-mutilation, Hyperesthesia, Painless fr... ORPHA:642
Mucopolysaccharidosis, Type Iiia
Hyperactivity OMIM:252900
7Q11.23 Microduplication Syndrome
Dysmetria, Self-injurious behavior, Aggressive behavior, Hyperactivity, Unsteady gait, Anxiety, I... ORPHA:96121
Prader-Willi Syndrome Due To Translocation
Skin-picking, Happy demeanor, Attention deficit hyperactivity disorder, Abnormal social behavior,... ORPHA:177907
Purine Nucleoside Phosphorylase Deficiency
Hyperactivity, Ataxia ORPHA:760
Fg Syndrome Type 1
Abnormal social behavior, Attention deficit hyperactivity disorder, Broad-based gait ORPHA:93932
Cerebellar Dysfunction With Variable Cognitive And Behavioral Abnormalities
Dysmetria, Aggressive behavior, Hyperactivity, Ataxia, Unsteady gait OMIM:614756
Tuberous Sclerosis Complex
Self-injurious behavior, Aggressive behavior, Hyperactivity, Impulsivity, Abnormal social behavio... ORPHA:805
Mucopolysaccharidosis Type 3
Gait disturbance, Dementia, Loss of ambulation, Aggressive behavior, Progressive neurologic deter... ORPHA:581
Brain-Lung-Thyroid Syndrome
Dystonia, Choreoathetosis, Chorea, Falls, Hyperactivity, Ataxia ORPHA:209905
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Dystonia, Violent behavior, Torticollis, Suicidal ideation, Cognitive impairment, Aggressive beha... OMIM:619475
Joubert Syndrome 1
Hyperactivity, Aggressive behavior, Self-mutilation, Ataxia OMIM:213300
Argininemia
Hyperactivity, Spastic gait, Irritability OMIM:207800
Dihydropyrimidine Dehydrogenase Deficiency
Abnormal social behavior, Inability to walk, Irritability, Abnormal aggressive, impulsive or viol... ORPHA:1675
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear/anxiety-related behavior, Agoraphobia, Self-injurious behavior, Aggressive behavior... ORPHA:353281
Hyperthyroidism, Nonautoimmune
Hyperactivity OMIM:609152
Mend Syndrome
Abnormal social behavior, Hyperactivity, Aggressive behavior ORPHA:401973
Mucopolysaccharidosis Type 2
Cognitive impairment, Aggressive behavior, Progressive neurologic deterioration, Hyperactivity, I... ORPHA:580
Early Infantile Epileptic Encephalopathy
Dystonia, Choreoathetosis, Self-injurious behavior, Hyperactivity, Episodic ataxia ORPHA:1934
Histidinemia
Hyperactivity ORPHA:2157
Koolen-De Vries Syndrome Due To A Point Mutation
Inappropriate laughter, Overfriendliness, Anxiety, Attention deficit hyperactivity disorder, Abno... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Inappropriate laughter, Overfriendliness, Anxiety, Attention deficit hyperactivity disorder, Abno... ORPHA:363958
Familial Gestational Hyperthyroidism
Hyperactivity ORPHA:99819
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear/anxiety-related behavior, Agoraphobia, Self-injurious behavior, Aggressive behavior... ORPHA:353277
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear/anxiety-related behavior, Agoraphobia, Self-injurious behavior, Aggressive behavior... ORPHA:353284
Familial Hyperthyroidism Due To Mutations In Tsh Receptor
Hyperactivity ORPHA:424
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hyperactivity, Hair-pulling, Irritability ORPHA:447997
Williams Syndrome
Gait disturbance, Gait imbalance, Dysmetria, Ataxia, Overfriendliness, Anxiety, Attention deficit... ORPHA:904
Monosomy 22Q13.3
Hyperactivity, Hair-pulling, Impaired pain sensation ORPHA:48652

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lpar5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lpar5.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Lpar5tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Lpar5tm1a(KOMP)Wtsi PMC6459510

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MGI Allele Allele Type Produced
Lpar5tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lpar5tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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